You can:
Name | Neuromedin-K receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | TACR3 |
Synonym | SP-N receptor Tac3r Nmkr NKR NK3 receptor [ Show all ] |
Disease | Schizophrenia Schizophrenia; Schizoaffective disorders Psychotic disorders Psychiatric disorder Irritable bowel syndrome [ Show all ] |
Length | 465 |
Amino acid sequence | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS |
UniProt | P29371 |
Protein Data Bank | N/A |
GPCR-HGmod model | P29371 |
3D structure model | This predicted structure model is from GPCR-EXP P29371. |
BioLiP | N/A |
Therapeutic Target Database | T29683 |
ChEMBL | CHEMBL4429 |
IUPHAR | 362 |
DrugBank | BE0002371 |
Name | Saredutant |
---|---|
Molecular formula | C31H35Cl2N3O2 |
IUPAC name | N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide |
Molecular weight | 552.54 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.9 |
Synonyms | CHEMBL308148 HY-106910 PDSP2_000650 SR 48968C UNII-720U2QK8I5 [ Show all ] |
Inchi Key | PGKXDIMONUAMFR-AREMUKBSSA-N |
Inchi ID | InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 |
PubChem CID | 104974 |
ChEMBL | CHEMBL308148 |
IUPHAR | 2111, 3481 |
BindingDB | 50071484 |
DrugBank | DB06660 |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 350.0 nM | PMID8117304 | IUPHAR |
Ki | 630.957 - 1995.26 nM | PMID9190866, PMID12206858 | IUPHAR |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218