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Name | Metabotropic glutamate receptor 2 |
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Species | Homo sapiens (Human) |
Gene | GRM2 |
Synonym | mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor |
Disease | Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder [ Show all ] |
Length | 872 |
Amino acid sequence | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL |
UniProt | Q14416 |
Protein Data Bank | 5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5cnj. |
BioLiP | BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443 |
Therapeutic Target Database | T62820 |
ChEMBL | CHEMBL5137 |
IUPHAR | 290 |
DrugBank | N/A |
Name | CHEMBL515034 |
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Molecular formula | C21H21F3N4O |
IUPAC name | 1-methyl-2-[[(1R,5S)-6-[[5-(trifluoromethyl)pyridin-2-yl]oxymethyl]-3-azabicyclo[3.1.0]hexan-3-yl]methyl]benzimidazole |
Molecular weight | 402.421 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.4 |
Synonyms | BDBM50263433 1-methyl-2-(((1R,5S)-6-((5-(trifluoromethyl)pyridin-2-yloxy)methyl)-3-aza-bicyclo[3.1.0]hexan-3-yl)methyl)-1H-benzo[d]imidazole |
Inchi Key | DTMCLRWXKBKQIR-XYPWUTKMSA-N |
Inchi ID | InChI=1S/C21H21F3N4O/c1-27-18-5-3-2-4-17(18)26-19(27)11-28-9-14-15(10-28)16(14)12-29-20-7-6-13(8-25-20)21(22,23)24/h2-8,14-16H,9-12H2,1H3/t14-,15+,16? |
PubChem CID | 25110723 |
ChEMBL | CHEMBL515034 |
IUPHAR | N/A |
BindingDB | 50263433 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 30.0 nM | PMID18812259 | BindingDB |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218