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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Mus musculus (Mouse)
Gene	Crhr2
Synonym	CRFR-2 CRFR2 CRFR2alpha CRFR2beta CRH-R-2 CRF2 receptor CRF-RB CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 CRH-R2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	411
Amino acid sequence	MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q60748
Protein Data Bank	2jnd
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jnd.
BioLiP	BL0101313
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2253
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL164829
Molecular formula	C20H18N6O2
IUPAC name	N-(2-aminoethyl)-20-hydroxy-3,6,10,12-tetrazapentacyclo[11.7.1.02,7.09,21.014,19]henicosa-1(20),2,7,9,11,13(21),14,16,18-nonaene-8-carboxamide
Molecular weight	374.404
Hydrogen bond acceptor	7
Hydrogen bond donor	4
XlogP	0.4
Synonyms	BDBM50075924 N-(2-Aminoethyl)-5,6-(iminoethyleneimino)-7-oxo-7H-benzo[e]perimidine-4-carboxamide 13-Oxo-10,11,12,13-tetrahydro-9H-5,7,9,12-tetraaza-dibenzo[a,de]anthracen-8-carboxylic acid (2-amino-ethyl)-amide
Inchi Key	VXGJDYBLBWXYBM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N6O2/c21-5-6-24-20(28)14-16-12-13(17-18(14)23-8-7-22-17)19(27)11-4-2-1-3-10(11)15(12)25-9-26-16/h1-4,9,23,27H,5-8,21H2,(H,24,28)
PubChem CID	135884427
ChEMBL	CHEMBL164829
IUPHAR	N/A
BindingDB	50075924
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	650.0 nM	PMID10201844	BindingDB,ChEMBL

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