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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 52
Species	Homo sapiens (Human)
Gene	GPR52
Synonym	GPR52
Disease	N/A
Length	361
Amino acid sequence	MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
UniProt	Q9Y2T5
Protein Data Bank	N/A
GPCR-HGmod model	Q9Y2T5
3D structure model	This predicted structure model is from GPCR-EXP Q9Y2T5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3297639
IUPHAR	108
DrugBank	N/A

Ligand

Name	CHEMBL3299118
Molecular formula	C22H20ClFN2O3
IUPAC name	3-[6-[2-(3-chloro-5-fluorophenyl)ethoxy]pyridin-2-yl]-N-(2-hydroxyethyl)benzamide
Molecular weight	414.861
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.1
Synonyms	BDBM50022151
Inchi Key	DHDZMCZZSVJZDH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20ClFN2O3/c23-18-11-15(12-19(24)14-18)7-10-29-21-6-2-5-20(26-21)16-3-1-4-17(13-16)22(28)25-8-9-27/h1-6,11-14,27H,7-10H2,(H,25,28)
PubChem CID	90645439
ChEMBL	CHEMBL3299118
IUPHAR	N/A
BindingDB	50022151
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	346.74 nM	PMID24884590	ChEMBL
EC50	347.0 nM	PMID24884590	BindingDB
Emax	79.0 %	PMID24884590	ChEMBL

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