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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL423711
Molecular formula	C28H26N4O
IUPAC name	3-[cyano-[4-(3,3-diphenylpropanoyl)piperazin-1-yl]methyl]benzonitrile
Molecular weight	434.543
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.1
Synonyms	2-[4-(3,3-Diphenylpropionyl)-1-piperazinyl]-2-(3-cyanophenyl)acetonitrile BDBM50003498 3-{Cyano-[4-(3,3-diphenyl-propionyl)-piperazin-1-yl]-methyl}-benzonitrile
Inchi Key	DYSMKZWCHPKQDB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H26N4O/c29-20-22-8-7-13-25(18-22)27(21-30)31-14-16-32(17-15-31)28(33)19-26(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-13,18,26-27H,14-17,19H2
PubChem CID	9980372
ChEMBL	CHEMBL423711
IUPHAR	N/A
BindingDB	50003498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	<5.0 mg.kg-1	PMID1433215	ChEMBL

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