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Name | Histamine H4 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL455133 |
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Molecular formula | C18H21N5O |
IUPAC name | N-(furan-2-ylmethyl)-2-(4-methylpiperazin-1-yl)quinazolin-4-amine |
Molecular weight | 323.4 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 2.7 |
Synonyms | AKOS022112642 MolPort-001-910-204 Oprea1_346663 AB00116419-01 Furan-2-ylmethyl-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-amine [ Show all ] |
Inchi Key | AKLTUAUOGNRRLK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H21N5O/c1-22-8-10-23(11-9-22)18-20-16-7-3-2-6-15(16)17(21-18)19-13-14-5-4-12-24-14/h2-7,12H,8-11,13H2,1H3,(H,19,20,21) |
PubChem CID | 805994 |
ChEMBL | CHEMBL455133 |
IUPHAR | N/A |
BindingDB | 50412509 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 602.56 nM | PMID19053770, PMID20192225 | BindingDB,ChEMBL |
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