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GLASS

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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	CHEMBL133910
Molecular formula	C23H43O5P
IUPAC name	butyl-[(Z)-6-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hex-4-enyl]phosphinic acid
Molecular weight	430.566
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	3.1
Synonyms	Butyl-{6-[3,5-dihydroxy-2-(3-hydroxy-oct-1-enyl)-cyclopentyl]-hex-4-enyl}-phosphinic acid Butyl[(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acid BDBM50106551
Inchi Key	FEWXWECWZNLKLR-NVTZDDNGSA-N
Inchi ID	InChI=1S/C23H43O5P/c1-3-5-9-12-19(24)14-15-21-20(22(25)18-23(21)26)13-10-7-8-11-17-29(27,28)16-6-4-2/h7,10,14-15,19-26H,3-6,8-9,11-13,16-18H2,1-2H3,(H,27,28)/b10-7-,15-14+/t19-,20+,21+,22-,23+/m0/s1
PubChem CID	11133782
ChEMBL	CHEMBL133910
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6700.0 nM	PMID11708917	ChEMBL

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