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Name | Muscarinic acetylcholine receptor M5 |
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Species | Homo sapiens (Human) |
Gene | CHRM5 |
Synonym | M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5 |
Disease | Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis [ Show all ] |
Length | 532 |
Amino acid sequence | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP |
UniProt | P08912 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T79961 |
ChEMBL | CHEMBL2035 |
IUPHAR | 17 |
DrugBank | BE0000247, BE0004890 |
Name | CHEMBL376295 |
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Molecular formula | C19H25N5O5S2 |
IUPAC name | 3-methoxy-4-[3-[3-[3-[(4-pyridin-3-yl-1,2,5-thiadiazol-3-yl)oxy]propoxy]propoxy]propoxy]-1,2,5-thiadiazole |
Molecular weight | 467.559 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 0 |
XlogP | 2.8 |
Synonyms | CDD-0314A |
Inchi Key | AKPSMQSQINOOPH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H25N5O5S2/c1-25-18-19(24-31-23-18)29-13-5-11-27-9-3-8-26-10-4-12-28-17-16(21-30-22-17)15-6-2-7-20-14-15/h2,6-7,14H,3-5,8-13H2,1H3 |
PubChem CID | 16094810 |
ChEMBL | CHEMBL376295 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 100.0 nM | PMID17149881 | ChEMBL |
Smax | 0.6 % | PMID17149881 | ChEMBL |
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