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Name | Neuropeptide Y receptor type 5 |
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Species | Homo sapiens (Human) |
Gene | NPY5R |
Synonym | NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor [ Show all ] |
Disease | Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity |
Length | 445 |
Amino acid sequence | MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM |
UniProt | Q15761 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15761 |
3D structure model | This predicted structure model is from GPCR-EXP Q15761. |
BioLiP | N/A |
Therapeutic Target Database | T20331 |
ChEMBL | CHEMBL4561 |
IUPHAR | 308 |
DrugBank | N/A |
Name | CHEMBL326736 |
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Molecular formula | C14H11N3 |
IUPAC name | 4-(5-phenyl-1H-imidazol-2-yl)pyridine |
Molecular weight | 221.263 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 2.3 |
Synonyms | 2-(4-Pyridyl)-4-phenyl-1H-imidazole 4-(4-phenyl-1H-imidazol-2-yl)pyridine BDBM50133774 SCHEMBL17269682 4-(5-Phenyl-1H-imidazol-2-yl)-pyridine |
Inchi Key | ALTJKNQLXJJFCN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H11N3/c1-2-4-11(5-3-1)13-10-16-14(17-13)12-6-8-15-9-7-12/h1-10H,(H,16,17) |
PubChem CID | 12250900 |
ChEMBL | CHEMBL326736 |
IUPHAR | N/A |
BindingDB | 50133774 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1527.0 nM | PMID14505677 | BindingDB,ChEMBL |
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