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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000732847
Molecular formula	C23H25N3O2
IUPAC name	3-ethyl-4-[[5-methyl-2-(4-phenylphenyl)-1,3-oxazol-4-yl]methyl]piperazin-2-one
Molecular weight	375.472
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.9
Synonyms	4-[(2-biphenyl-4-yl-5-methyl-1,3-oxazol-4-yl)methyl]-3-ethylpiperazin-2-one MCULE-4739893114 BDBM46409 3-ethyl-4-[[5-methyl-2-(4-phenylphenyl)-4-oxazolyl]methyl]-2-piperazinone cid_16190638 4-{[2-(4-biphenylyl)-5-methyl-1,3-oxazol-4-yl]methyl}-3-ethyl-2-piperazinone 3-ethyl-4-[[5-methyl-2-(4-phenylphenyl)oxazol-4-yl]methyl]piperazin-2-one HMS2755M13 SMR000316479 3-ethyl-4-[[5-methyl-2-(4-phenylphenyl)-1,3-oxazol-4-yl]methyl]piperazin-2-one CHEMBL1603032 [ Show all ]
Inchi Key	FUSSCZQVVQIIPW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25N3O2/c1-3-21-22(27)24-13-14-26(21)15-20-16(2)28-23(25-20)19-11-9-18(10-12-19)17-7-5-4-6-8-17/h4-12,21H,3,13-15H2,1-2H3,(H,24,27)
PubChem CID	16190638
ChEMBL	CHEMBL1603032
IUPHAR	N/A
BindingDB	46409
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2764.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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