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Name | Gonadotropin-releasing hormone receptor |
---|---|
Species | Macaca mulatta (Rhesus macaque) |
Gene | GNRHR |
Synonym | GnRH receptor GnRH-R |
Disease | N/A for non-human GPCRs |
Length | 59 |
Amino acid sequence | VAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | Q8SPZ1 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5647 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL509075 |
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Molecular formula | C31H28F5N3O5 |
IUPAC name | 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid |
Molecular weight | 617.573 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 2 |
XlogP | 2.3 |
Synonyms | (R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric Acid (R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(2-fluoro-3-methoxyphenyl)-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethylamino)butanoic acid BDBM50260759 SCHEMBL1378026 |
Inchi Key | FWSQRSDDLDNXGE-VWLOTQADSA-N |
Inchi ID | InChI=1S/C31H28F5N3O5/c1-44-26-13-5-10-20(28(26)33)21-16-38(17-22-23(31(34,35)36)11-6-12-24(22)32)30(43)39(29(21)42)18-25(19-8-3-2-4-9-19)37-15-7-14-27(40)41/h2-6,8-13,16,25,37H,7,14-15,17-18H2,1H3,(H,40,41)/t25-/m0/s1 |
PubChem CID | 11331001 |
ChEMBL | CHEMBL509075 |
IUPHAR | N/A |
BindingDB | 50260759 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 81.0 nM | PMID18442910 | ChEMBL |
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