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| Name | Gastrin-releasing peptide receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | GRPR |
| Synonym | GRP-R GRP-preferring bombesin receptor gastrin-releasing peptide receptor BB2 receptor BB2 |
| Disease | Solid tumours Breast cancer Cancer Irritable bowel syndrome |
| Length | 384 |
| Amino acid sequence | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV |
| UniProt | P30550 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P30550 |
| 3D structure model | This predicted structure model is from GPCR-EXP P30550. |
| BioLiP | N/A |
| Therapeutic Target Database | T99816 |
| ChEMBL | CHEMBL4959 |
| IUPHAR | 39 |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 4051 |  CHEMBL313030 | C35H41N5O4 | 595.744 | 4 / 4 | 7.4 | No |
| 4071 |  PD 168368 | C31H34N6O4 | 554.651 | 5 / 4 | 5.2 | No |
| 5309 |  CHEMBL88174 | C32H44N4O2 | 516.73 | 2 / 3 | 7.2 | No |
| 8915 |  CHEMBL316085 | C31H34ClN5O2 | 544.096 | 3 / 4 | 6.0 | No |
| 547987 |  CHEMBL3908441 | C67H106N20O20S2 | 1575.82 | 24 / 20 | -4.7 | No |
| 536304 |  SCHEMBL1251302 | C68H100N18O18S | 1489.72 | 24 / 16 | -7.2 | No |
| 11974 |  CHEMBL2429981 | C78H124FN19O16Si | 1631.05 | 19 / 19 | N/A | No |
| 548037 |  CHEMBL3953851 | C72H117N25O17S2 | 1669.01 | 24 / 21 | -4.7 | No |
| 553325 |  Ranatensin | C61H84N16O13S | 1281.5 | 15 / 14 | 0.4 | No |
| 16305 |  CHEMBL2429980 | C74H115FN16O20S2Si | 1660.03 | 22 / 17 | N/A | No |
| 17330 |  CHEMBL315660 | C31H42N4O2 | 502.703 | 2 / 4 | 6.8 | No |
| 536468 |  CHEMBL3951222 | C68H98ClN19O18S | 1537.16 | 24 / 17 | -7.3 | No |
| 20461 |  CHEMBL3144503 | C32H35N5O4 | 553.663 | 4 / 5 | 2.6 | No |
| 20464 |  CHEMBL417947 | C32H35N5O4 | 553.663 | 4 / 5 | 2.6 | No |
| 20547 |  CHEMBL1907865 | C35H42N4O2 | 550.747 | 2 / 4 | 7.1 | No |
| 20550 |  CHEMBL315859 | C35H42N4O2 | 550.747 | 2 / 4 | 7.1 | No |
| 548120 |  CHEMBL3960301 | C68H105N21O19S2 | 1584.84 | 25 / 19 | -6.5 | No |
| 548129 |  CHEMBL3922805 | C69H111N23O17S2 | 1598.91 | 25 / 20 | -4.8 | No |
| 548141 |  CHEMBL3914573 | C68H106N20O21S2 | 1603.83 | 25 / 20 | -6.8 | No |
| 548145 |  CHEMBL3943104 | C67H107N21O19S2 | 1574.84 | 25 / 20 | -5.0 | No |
| 548148 |  CHEMBL3917426 | C70H112N20O21S2 | 1633.91 | 25 / 19 | -4.4 | No |
| 28028 |  Compound GRP | C130H203N37O32S2 | 2860.4 | 39 / 36 | -3.9 | No |
| 35406 |  Universal ligand | C57H76N14O11 | 1133.32 | 13 / 14 | 2.1 | No |
| 536919 |  CHEMBL3928975 | C71H97N19O18S | 1536.73 | 24 / 17 | -7.7 | No |
| 39324 |  CHEMBL269432 | C51H72N10O12 | 1017.2 | 13 / 11 | 3.2 | No |
| 47164 |  CHEMBL92274 | C31H42N4O4 | 534.701 | 4 / 4 | 5.1 | No |
| 548495 |  CHEMBL3980591 | C106H171N25O27S | 2259.74 | 34 / 25 | -7.7 | No |
| 553510 |  bantag-1 | C49H82N8O7+2 | 895.244 | 8 / 8 | 5.2 | No |
| 537385 |  SCHEMBL1251393 | C85H131N19O19S | 1755.16 | 25 / 17 | -4.0 | No |
| 548586 |  CHEMBL3891981 | C68H99N19O19S | 1518.71 | 25 / 18 | -8.3 | No |
| 62574 |  CHEMBL313829 | C33H40N4O2 | 524.709 | 2 / 4 | 6.8 | No |
| 63937 |  CHEMBL87846 | C32H35N5O5 | 569.662 | 5 / 5 | 5.9 | No |
| 537520 |  SCHEMBL1392465 | C85H133N19O20S | 1773.17 | 26 / 19 | -5.0 | No |
| 548652 |  CHEMBL3978275 | C68H106N20O21S2 | 1603.83 | 25 / 20 | -6.8 | No |
| 548674 |  CHEMBL3924852 | C70H113N21O19S2 | 1616.92 | 24 / 20 | -3.9 | No |
| 548720 |  CHEMBL3942065 | C59H91N17O16S | 1326.54 | 22 / 15 | -8.1 | No |
| 537718 |  SCHEMBL1251567 | C85H133N19O19S | 1757.17 | 25 / 18 | -3.7 | No |
| 548728 |  CHEMBL3954296 | C70H113N23O19S2 | 1644.94 | 24 / 21 | -4.9 | No |
| 548736 |  CHEMBL3906914 | C69H110N22O18S2 | 1599.9 | 24 / 20 | -4.6 | No |
| 73590 |  CHEMBL312926 | C33H37N5O5 | 583.689 | 5 / 4 | 6.2 | No |
| 537833 |  55749-98-9 | C38H57N11O7S | 812.004 | 10 / 10 | 1.0 | No |
| 78023 |  CHEMBL328591 | C32H44N4O2 | 516.73 | 2 / 3 | 7.2 | No |
| 80689 |  CHEMBL89153 | C32H44N4O2 | 516.73 | 2 / 4 | 7.2 | No |
| 548858 |  CHEMBL3974259 | C72H115N21O22S2 | 1690.96 | 26 / 20 | -5.0 | No |
| 548882 |  CHEMBL3956432 | C72H116N22O19S2 | 1657.97 | 25 / 19 | -4.2 | No |
| 84457 |  CHEMBL1907682 | C37H46N4O2 | 578.801 | 2 / 4 | 8.0 | No |
| 548896 |  CHEMBL3954412 | C88H115N19O19S | 1775.06 | 25 / 17 | -2.9 | No |
| 548987 |  CHEMBL3953118 | C69H109N21O21S2 | 1632.88 | 25 / 21 | -5.4 | No |
| 549058 |  CHEMBL3946856 | C67H107N21O18S2 | 1558.84 | 23 / 21 | -4.3 | No |
| 549066 |  CHEMBL3962352 | C69H108N20O21S2 | 1617.86 | 25 / 20 | -6.5 | No |
| 538416 |  CHEMBL3890803 | C71H98N18O18S | 1523.73 | 24 / 17 | -6.8 | No |
| 99850 |  CHEMBL525577 | C57H76N14O10 | 1117.32 | 12 / 13 | 2.5 | No |
| 549102 |  CHEMBL3908400 | C70H112N24O17S2 | 1625.94 | 24 / 20 | -4.6 | No |
| 538465 |  CHEMBL3894747 | C68H100N20O18S | 1517.73 | 25 / 18 | -7.1 | No |
| 549119 |  CHEMBL3905562 | C69H109N21O21S2 | 1632.88 | 25 / 21 | -5.4 | No |
| 549120 |  CHEMBL3921363 | C69H110N22O20S2 | 1631.89 | 26 / 21 | -5.6 | No |
| 549142 |  CHEMBL3985283 | C72H101N19O18S | 1552.78 | 24 / 17 | -6.7 | No |
| 549188 |  CHEMBL3969439 | C69H108N20O20S2 | 1601.86 | 24 / 19 | -4.4 | No |
| 549190 |  CHEMBL3909253 | C70H110N22O19S2 | 1627.91 | 25 / 20 | -6.7 | No |
| 538628 |  SCHEMBL1250067 | C69H101N19O18S | 1516.74 | 24 / 17 | -7.6 | No |
| 549240 |  CHEMBL3944194 | C61H82N16O14S | 1295.48 | 17 / 17 | -0.6 | No |
| 549256 |  CHEMBL3978062 | C67H103N19O18S | 1494.74 | 24 / 16 | -8.4 | No |
| 549273 |  CHEMBL3901669 | C72H116N22O20S2 | 1673.97 | 25 / 21 | -4.6 | No |
| 114273 |  CHEMBL314375 | C45H67N13O10S | 982.172 | 12 / 12 | 0.0 | No |
| 549291 |  CHEMBL3956532 | C72H117N23O17S2 | 1640.99 | 25 / 20 | -3.8 | No |
| 549304 |  CHEMBL3967904 | C79H117N25O21S | 1785.02 | 25 / 26 | -6.9 | No |
| 549317 |  CHEMBL3917120 | C73H105N21O18S | 1596.83 | 26 / 15 | -8.1 | No |
| 119083 |  Surinabant | C23H23BrCl2N4O | 522.268 | 3 / 1 | 7.0 | No |
| 549377 |  CHEMBL3911959 | C63H99N18O17S+ | 1412.65 | 23 / 15 | -8.3 | No |
| 539001 |  CHEMBL3975022 | C69H98N20O17S | 1511.73 | 24 / 17 | -7.0 | No |
| 539020 |  SCHEMBL14959373 | C94H137N27O26S | 2093.35 | 33 / 26 | -11.3 | No |
| 539143 |  SCHEMBL1252671 | C69H101N19O18S | 1516.74 | 24 / 16 | -7.8 | No |
| 539202 |  SCHEMBL1252293 | C68H99N19O18S | 1502.71 | 24 / 17 | -8.0 | No |
| 539225 |  SCHEMBL2292312 | C89H141N19O22S | 1861.28 | 28 / 19 | -5.3 | No |
| 549562 |  CHEMBL3952732 | C69H100N18O18S | 1501.73 | 25 / 16 | -7.7 | No |
| 132520 |  CHEMBL89734 | C33H37N5O5 | 583.689 | 5 / 4 | 6.2 | No |
| 133465 |  CHEMBL272335 | C57H91N15O11S | 1194.51 | 14 / 14 | 1.4 | No |
| 133506 |  BDBM50279043 | C69H106N24O19S | 1607.82 | 22 / 23 | -6.8 | No |
| 135435 |  CHEMBL414307 | C61H94N18O12S | 1303.6 | 18 / 17 | -1.5 | No |
| 539403 |  SCHEMBL1252416 | C68H99N19O18S | 1502.71 | 24 / 17 | -8.0 | No |
| 136017 |  CHEMBL90614 | C32H34F3N5O2 | 577.652 | 6 / 4 | 6.3 | No |
| 539429 |  CHEMBL3927340 | C65H95N19O16S2 | 1462.71 | 20 / 18 | -1.7 | No |
| 137372 |  CHEMBL505216 | C56H87N17O13S2 | 1270.54 | 17 / 17 | -1.6 | No |
| 137373 |  CHEMBL2372320 | C56H87N17O13S2 | 1270.54 | 17 / 17 | -1.6 | No |
| 549622 |  CHEMBL3894546 | C87H115N19O18S | 1747.05 | 24 / 17 | -2.6 | No |
| 549627 |  CHEMBL3891679 | C80H115N19O20S | 1694.97 | 26 / 17 | -6.3 | No |
| 549641 |  CHEMBL3929807 | C77H121N19O18S | 1632.99 | 24 / 17 | -3.2 | No |
| 539562 |  SCHEMBL1250077 | C68H100N18O17S | 1473.72 | 23 / 16 | -7.4 | No |
| 549671 |  CHEMBL3969493 | C69H108N20O21S2 | 1617.86 | 25 / 20 | -6.5 | No |
| 549676 |  CHEMBL3944228 | C69H109N21O19S2 | 1600.88 | 24 / 21 | -6.0 | No |
| 553992 |  Rc-3095 | C56H79N15O9 | 1106.34 | 12 / 14 | 2.2 | No |
| 145375 |  CHEMBL1079517 | C25H30N2O3 | 406.526 | 4 / 3 | 5.0 | Yes |
| 549751 |  CHEMBL3967299 | C68H102N19O20PS | 1568.71 | 26 / 18 | -9.3 | No |
| 147743 |  CHEMBL89813 | C31H34N6O4 | 554.651 | 5 / 4 | 5.8 | No |
| 549769 |  CHEMBL3945599 | C65H101N19O17S | 1452.7 | 24 / 15 | -8.8 | No |
| 447784 |  CHEMBL3401466 | C70H104BF3N20O13 | 1501.53 | 21 / 15 | N/A | No |
| 447785 |  CHEMBL3401467 | C70H104BF3N20O13 | 1499.54 | 21 / 15 | N/A | No |
| 540067 |  CHEMBL3974200 | C67H98N20O18S | 1503.7 | 25 / 17 | -8.7 | No |
| 158838 |  CHEMBL313114 | C26H34N4O2 | 434.584 | 2 / 4 | 4.8 | Yes |
| 165318 |  CHEMBL87079 | C31H35N5O2 | 509.654 | 3 / 4 | 5.4 | No |
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