Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

You can:

GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Known ligands

You can:

Total entries: 250
Page:  / 3 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
39092D structureMLS000331633C22H15NO5373.3646 / 03.9Yes
58642D structureMLS000557918C20H24N4O2352.4384 / 13.7Yes
72152D structureMLS000779074C20H19NO3321.3764 / 13.7Yes
74932D structure2-Benzylidene-1,2-dihydro-indol-3-oneC15H11NO221.2592 / 13.6Yes
91892D structureMLS000699016C11H12N2O3S3316.4087 / 12.0Yes
91902D structureMLS000703412C11H12N2O3S3316.4087 / 12.0Yes
112992D structureMLS000713029C18H23N3O3329.45 / 13.1Yes
159832D structure(5Z)-5-(4-hydroxybenzylidene)-3-(tetrahydrofuran-2-ylmethyl)-2-thioxo-1,3-thiazolidin-4-oneC15H15NO3S2321.4095 / 13.0Yes
170782D structureSMR000118449C16H32N4O6376.4548 / 2-2.6Yes
172202D structure2-(4-chlorophenyl)-N-(2-methoxy-5-nitrophenyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxamideC23H16ClN3O5449.8475 / 14.1Yes
178132D structureSMR000129696C16H10F3N5OS3441.46511 / 24.7No
178472D structureMLS000689985C23H17NO4371.3924 / 14.2Yes
180102D structureMLS000028153C15H19N3241.3382 / 12.4Yes
192422D structureNicotinamide_dinucleotideC21H27N7O14P2663.4318 / 7-6.0No
212392D structure708241-96-7C17H18BrN3O2376.2544 / 13.7Yes
272322D structure2-methoxy-N-[2-(3-methyl-4-nitro-5-isoxazolyl)vinyl]anilineC13H13N3O4275.2646 / 12.6Yes
272372D structureCHEMBL224730C23H32N9O5+514.5677 / 5-2.5No
282992D structure(2E,5E)-2,5-bis(2,4-dimethoxybenzylidene)cyclopentanoneC23H24O5380.445 / 04.4Yes
305732D structureTCMDC-123502C18H21Cl2NO338.2722 / 24.7Yes
5582732D structureAC1NZ11RC19H23N3O5S405.4697 / 32.2Yes
378552D structureMLS000714665C17H19NO4S2365.4626 / 13.4Yes
385502D structureMLS000698167C22H24IN3O473.3582 / 1N/AN/A
388322D structureCHEMBL224655C21H32N6O4432.5255 / 4-0.4Yes
410932D structureMLS000554145C19H21N3OS339.4573 / 13.6Yes
414202D structure2,3,6-triphenylimidazo[1,2-b][1,2,4]triazineC23H16N4348.4093 / 04.7Yes
418982D structureAM-1638C33H35FO4514.6375 / 17.8No
426792D structureMLS001033855C13H13BrFN3S342.234 / 2N/AN/A
437202D structureMLS001018872C21H23N3O2349.4343 / 23.1Yes
462562D structureMLS000579119C18H15ClN2O4358.7785 / 13.1Yes
528842D structureCHEMBL1484167C26H29BrN2OS497.4954 / 1N/AN/A
536882D structureMLS000677316C17H11N3O5337.2916 / 12.5Yes
539902D structureSMR000043948C21H16N4O3S404.4446 / 13.1Yes
563512D structure(6E)-5-imino-2-isobutyl-6-[(4-oxo-4H-chromen-3-yl)methylene]-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneC19H16N4O3S380.4226 / 13.1Yes
572632D structure(2-{[2-(4-Fluorophenyl)-1H-indol-3-yl]thio}ethyl)amineC16H15FN2S286.3683 / 23.4Yes
588832D structureSMR000105815C13H11F3N2O2284.2387 / 02.5Yes
5535522D structureMeTRHC17H24N6O4376.4175 / 3-2.3Yes
617702D structureMLS000778612C18H16N2O5S3436.5158 / 23.8Yes
624952D structure1-Pentyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxalineC20H20N4316.4083 / 04.4Yes
639432D structure2-(2-hydroxy-5-methylbenzoyl)pyrido[1,2-a][1,3]benzimidazole-4-carbonitrileC20H13N3O2327.3434 / 14.8Yes
654302D structureMLS000082525C15H17N3O4S335.3787 / 12.1Yes
721172D structureMLS000536105C17H11ClF3N3O3S2461.85810 / 25.2No
728102D structureMLS002157414C21H19N3O5S425.4597 / 12.3Yes
730312D structureCHEMBL374625C20H29N5O4403.4835 / 3-0.9Yes
730322D structureCHEMBL224715C20H29N5O4403.4835 / 3-0.9Yes
755412D structureAC1O3J72C17H14N2O3S2358.435 / 15.1No
5596462D structure6-bromo-N'-[(1E)-(2-hydroxy-3-methoxyphenyl)methylene]-2-methylimidazo[1,2-a]pyridine-3-carbohydrazideC17H15BrN4O3403.2365 / 23.7Yes
772382D structureMLS001116411C22H27ClFN3O2S451.9856 / 14.6Yes
777472D structureMLS001173005C18H16N2O3308.3374 / 12.7Yes
814632D structure3-(trifluoromethyl)benzo[g]quinoxalin-2-olC13H7F3N2O264.2075 / 13.1Yes
819842D structureSMR000078105C16H12N4OS3372.4797 / 24.4Yes
825182D structureMLS000779148C16H9N3O4S339.3256 / 21.5Yes
859922D structureBAS 00429920C22H20N2O4376.4125 / 13.1Yes
886792D structureMLS001166676C20H20N2O4352.395 / 23.0Yes
891042D structureMLS000862743C22H35NO5S425.5846 / 02.9Yes
915722D structure1-tert-butyl-3-methyl-4-[(2-nitrophenyl)thio]-1H-pyrazol-5-yl acetateC16H19N3O4S349.4056 / 03.5Yes
916192D structureMLS000712878C19H18N2O5354.3625 / 22.9Yes
5601512D structure3-hydroxy-4-((E)-{[(5-methoxy-1-methyl-1H-indol-2-yl)carbonyl]hydrazono}methyl)-2-naphthoic acidC23H19N3O5417.4216 / 34.2Yes
994642D structureST041961C19H19NO2293.3663 / 02.8Yes
999112D structureMLS001100829C25H26FN3O3435.4996 / 14.0Yes
1001452D structureMLS001207297C17H12N2O4S2372.4136 / 33.4Yes
5605362D structureAC1OBEWPC19H17N3O3335.3635 / 12.8Yes
5605892D structureMLS000595131C23H23N3O4S437.5146 / 23.7Yes
1088482D structure2-chloro-6-fluoro-N-[2-(4-methoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]benzamideC22H17ClFN3O2409.8454 / 15.7No
1106682D structureAC1LTR2RC19H16N2O6S2432.4658 / 33.4Yes
1135772D structureCHEMBL223876C20H29N5O4403.4835 / 3-1.0Yes
1135782D structureCHEMBL388350C20H29N5O4403.4835 / 3-1.0Yes
1160812D structureMLS000586692C19H16N2O6S400.4058 / 23.4Yes
5609472D structureMLS001125585C16H11BrN2O3359.1794 / 24.1Yes
1178672D structureMLS001199446C17H13FO5S348.3446 / 13.4Yes
1186132D structureCHEMBL388812C20H30N6O4418.4985 / 4-0.9Yes
1188782D structureMLS000570530C18H15BrN2O4403.2325 / 34.0Yes
1191742D structureN-{4-[1-benzoyl-5-(2,3-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamideC25H25N3O5S479.5517 / 13.3Yes
1197352D structureN-(2-chlorobenzyl)-N'-(2-methylphenyl)-N-(pyridin-3-ylmethyl)thioureaC21H20ClN3S381.9222 / 14.6Yes
1206052D structureSMR000172341C19H13F3N2O4S422.3789 / 23.5Yes
5610812D structureAC1NSAWCC18H15N3O3321.3365 / 31.8Yes
1253202D structureAC1M3Q9PC23H23ClN2O3S442.9585 / 16.2No
1255302D structureAC1O5PEJC22H25ClN2O3400.9034 / 1N/AN/A
1299452D structureCHEMBL389037C24H30N6O4466.5425 / 30.1Yes
1335332D structure1-(3-methoxyphenyl)-2-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3,4,9-tetrahydro-1H-beta-carbolineC23H24N4O372.4723 / 13.4Yes
1335992D structure4-(benzofuran-2-carbonyl)-3-hydroxy-5-phenyl-1-(thiazol-2-yl)-1H-pyrrol-2(5H)-oneC22H14N2O4S402.4246 / 14.6Yes
1336472D structureMLS000777053C21H12N2O4S388.3976 / 14.4Yes
1343942D structureSMR000218862C22H16ClNO4393.8235 / 04.5Yes
1344592D structureMLS001138759C28H30N4O6518.577 / 23.4No
1371272D structurePyronin YC17H19ClN2O302.8023 / 0N/AN/A
1411662D structureN-(5,7-diphenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)acetamideC19H17N5O331.3794 / 23.3Yes
1457792D structureNECAC12H16N6O4308.2988 / 4-0.7Yes
1479552D structureMLS000521066C20H21N3O2335.4073 / 12.9Yes
1486512D structure2-methylpropyl 6-(6-bromo(2H-benzo[d]1,3-dioxolan-5-yl))-3,4-dimethyl-2-oxo-1, 3,6-trihydropyrimidine-5-carboxylateC18H21BrN2O5425.2795 / 13.0Yes
1519952D structureMLS000580448C12H22N2OS242.3812 / 12.4Yes
1559772D structureMLS000775763C21H16F2N2O5S446.4259 / 34.6Yes
1648102D structureSMR000062009C20H18N6O3S422.4637 / 32.1Yes
1685702D structureSMR000147498C22H20ClN3OS2441.9925 / 16.2No
1706032D structure4-amino-5-[(4-methoxyphenoxy)methyl]-4H-1,2,4-triazole-3-thiolC10H12N4O2S252.2925 / 20.9Yes
1714822D structureMLS002162744C21H24N4O2364.4494 / 12.9Yes
1727742D structureMLS000418558C28H35N5O3489.626 / 12.4Yes
1740112D structureSMR000078971C21H26N2O5S2450.5687 / 02.6Yes
1742522D structure3-(2-oxo-2-phenylethyl)quinoxalin-2(1h)-oneC16H12N2O2264.2843 / 12.2Yes
1777242D structureCHEMBL389858C21H31N5O4417.515 / 3-0.4Yes
1777252D structureCHEMBL389955C21H31N5O4417.515 / 3-0.4Yes
1779172D structureMLS001215909C17H17IN2376.2411 / 1N/AN/A

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218