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| Name | Melatonin receptor type 1B |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | MTNR1B |
| Synonym | MT2 receptor mel1b receptor Mel-1B-R |
| Disease | Epilepsy |
| Length | 362 |
| Amino acid sequence | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL |
| UniProt | P49286 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P49286 |
| 3D structure model | This predicted structure model is from GPCR-EXP P49286. |
| BioLiP | N/A |
| Therapeutic Target Database | T48268 |
| ChEMBL | CHEMBL1946 |
| IUPHAR | 288 |
| DrugBank | BE0000327 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 913 |  CHEMBL2326200 | C22H25NO3 | 351.446 | 3 / 1 | 4.3 | Yes |
| 441707 |  CHEMBL3329375 | C20H19FN2O3 | 354.381 | 4 / 1 | 3.3 | Yes |
| 1100 |  CHEMBL476341 | C24H27NO3 | 377.484 | 3 / 2 | 4.3 | Yes |
| 1111 |  CHEMBL99502 | C14H17BrN2O2 | 325.206 | 2 / 2 | 2.8 | Yes |
| 521498 |  CHEMBL3760044 | C18H20N2O3 | 312.369 | 3 / 2 | 3.3 | Yes |
| 2245 |  CHEMBL124914 | C14H18N2O2 | 246.31 | 3 / 1 | 2.5 | Yes |
| 2312 |  CHEMBL1088826 | C24H25NO3 | 375.468 | 3 / 1 | 4.9 | Yes |
| 4834 |  SCHEMBL2299352 | C15H16N2O2 | 256.305 | 3 / 1 | 1.8 | Yes |
| 4857 |  CHEMBL14453 | C32H36N2O4 | 512.65 | 4 / 2 | 5.9 | No |
| 5078 |  CHEMBL1774516 | C18H20F3NO2 | 339.358 | 5 / 1 | 3.6 | Yes |
| 5518 |  CHEMBL184562 | C26H31NO2 | 389.539 | 2 / 1 | 6.3 | No |
| 7326 |  CHEMBL562328 | C18H25N3O2 | 315.417 | 3 / 1 | 1.5 | Yes |
| 8076 |  CHEMBL1823015 | C18H19N3O2 | 309.369 | 3 / 2 | 2.6 | Yes |
| 9637 |  CHEMBL2112727 | C16H20N2O2 | 272.348 | 3 / 1 | 2.8 | Yes |
| 12668 |  CHEMBL96562 | C20H19Cl2NO3 | 392.276 | 3 / 1 | 5.1 | No |
| 464445 |  CHEMBL3580912 | C15H16N2O2 | 256.305 | 3 / 1 | 3.1 | Yes |
| 521846 |  CHEMBL3740377 | C32H32F4N2O4 | 584.612 | 8 / 2 | 7.6 | No |
| 13608 |  CHEMBL300729 | C13H15N3O4 | 277.28 | 4 / 2 | 1.4 | Yes |
| 14670 |  CHEMBL361854 | C26H33NO2 | 391.555 | 2 / 1 | 6.0 | No |
| 14677 |  CHEMBL341705 | C16H22N2O2 | 274.364 | 3 / 1 | 2.4 | Yes |
| 14679 |  CHEMBL136531 | C16H22N2O2 | 274.364 | 3 / 1 | 2.4 | Yes |
| 15079 |  CHEMBL19432 | C14H19FN2O2 | 266.316 | 4 / 0 | 1.1 | Yes |
| 15534 |  920317-71-1 | C18H21NO2 | 283.371 | 2 / 1 | 3.2 | Yes |
| 17013 |  CHEMBL363321 | C18H19NO | 265.356 | 1 / 1 | 3.2 | Yes |
| 18434 |  17994-17-1 | C12H14N2O2 | 218.256 | 3 / 2 | 0.8 | Yes |
| 18931 |  CHEMBL457807 | C22H24BrN3O2 | 442.357 | 3 / 2 | 4.0 | Yes |
| 20121 |  CHEMBL1209788 | C33H38ClF2N3O3 | 598.132 | 7 / 0 | 4.8 | No |
| 553338 |  [125I]SD6 | C13H15IN2O2 | 356.18 | 2 / 2 | 1.5 | Yes |
| 20287 |  CHEMBL298335 | C13H15N3O4 | 277.28 | 4 / 2 | 1.4 | Yes |
| 20758 |  CHEMBL34729 | C15H18N2O2 | 258.321 | 2 / 2 | 2.2 | Yes |
| 21353 |  CHEMBL139497 | C15H22N2O2 | 262.353 | 3 / 1 | 2.4 | Yes |
| 21362 |  CHEMBL181687 | C25H33NO2 | 379.544 | 2 / 1 | 6.2 | No |
| 21803 |  N-(3,3-diphenylpropyl)acetamide | C17H19NO | 253.345 | 1 / 1 | 3.3 | Yes |
| 21809 |  CHEMBL331636 | C17H24N2O2 | 288.391 | 3 / 1 | 3.9 | Yes |
| 22007 |  CHEMBL1813320 | C27H40N4O4 | 484.641 | 6 / 2 | 3.5 | Yes |
| 22916 |  CHEMBL1779803 | C12H12FNOS | 237.292 | 3 / 1 | 2.6 | Yes |
| 442578 |  CHEMBL3329371 | C22H33N3O2S | 403.585 | 4 / 1 | 3.3 | Yes |
| 23665 |  (hydroxymethylphenyl)agomelatine | C22H23NO3 | 349.43 | 3 / 2 | 3.5 | Yes |
| 24350 |  CHEMBL1095196 | C31H33NO5 | 499.607 | 5 / 1 | 6.1 | No |
| 24825 |  CHEMBL1097496 | C30H34N2O5 | 502.611 | 5 / 2 | 5.1 | No |
| 24902 |  CHEMBL8004 | C18H20N2O2 | 296.37 | 3 / 2 | 3.5 | Yes |
| 25607 |  5-MeOT-N-pentanyl | C19H27N3O2 | 329.444 | 2 / 3 | 2.6 | Yes |
| 27333 |  CHEMBL124783 | C16H22N2O2 | 274.364 | 3 / 1 | 3.4 | Yes |
| 27942 |  CHEMBL98956 | C13H15BrN2O2 | 311.179 | 2 / 2 | 2.3 | Yes |
| 28019 |  CHEMBL1760954 | C14H20N4O2 | 276.34 | 4 / 2 | 0.2 | Yes |
| 29592 |  CHEMBL238049 | C20H24N2O2 | 324.424 | 3 / 1 | 3.9 | Yes |
| 30157 |  CHEMBL10328 | C21H22N2O | 318.42 | 1 / 1 | 3.7 | Yes |
| 466736 |  CHEMBL3580909 | C14H16N2O2 | 244.294 | 2 / 2 | 1.9 | Yes |
| 31277 |  CHEMBL1223277 | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 31280 |  N-[2-(3-Methoxyphenoxy)-1-methylethyl]acetamide | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 31281 |  CHEMBL1223278 | C12H17NO3 | 223.272 | 3 / 1 | 1.6 | Yes |
| 31959 |  CHEMBL359576 | C33H30F3NO3 | 545.602 | 6 / 0 | 7.5 | No |
| 32725 |  CHEMBL323332 | C13H15NO3 | 233.267 | 3 / 1 | 1.9 | Yes |
| 32838 |  CHEMBL1223280 | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 32841 |  N-{2-[(3-methoxyphenyl)thio]-1-methylethyl}acetamide | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 32842 |  CHEMBL1223281 | C12H17NO2S | 239.333 | 3 / 1 | 2.2 | Yes |
| 34342 |  CHEMBL1095195 | C34H38N2O4 | 538.688 | 4 / 2 | 6.7 | No |
| 34377 |  CHEMBL99987 | C22H24N2O2 | 348.446 | 2 / 1 | 4.2 | Yes |
| 35509 |  CHEMBL1092646 | C20H25NO4 | 343.423 | 4 / 1 | 3.3 | Yes |
| 35533 |  CHEMBL3260984 | C19H29NO3 | 319.445 | 3 / 1 | 4.1 | Yes |
| 35873 |  CHEMBL382439 | C19H26N2O2 | 314.429 | 2 / 1 | 3.4 | Yes |
| 36457 |  920317-82-4 | C19H21NO3 | 311.381 | 3 / 1 | 3.5 | Yes |
| 37024 |  CHEMBL1774527 | C22H23NO3 | 349.43 | 3 / 1 | 3.0 | Yes |
| 37252 |  CHEMBL7567 | C18H20N2O2 | 296.37 | 3 / 1 | 3.2 | Yes |
| 37675 |  CHEMBL553105 | C18H26N2O2 | 302.418 | 3 / 2 | 3.7 | Yes |
| 38895 |  SCHEMBL2299672 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 38897 |  SCHEMBL2296992 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 38899 |  SCHEMBL2296995 | C15H18N2O2 | 258.321 | 3 / 1 | 2.5 | Yes |
| 467718 |  CHEMBL3580917 | C13H13N3O2 | 243.266 | 4 / 1 | 2.1 | Yes |
| 39249 |  CHEMBL117617 | C23H21NO4 | 375.424 | 4 / 1 | 4.2 | Yes |
| 39257 |  CHEMBL136564 | C15H21N3O2 | 275.352 | 3 / 2 | 1.8 | Yes |
| 39258 |  CHEMBL136431 | C15H21N3O2 | 275.352 | 3 / 2 | 1.8 | Yes |
| 467791 |  CHEMBL3580924 | C14H16N4OS | 288.369 | 3 / 2 | 2.0 | Yes |
| 39723 |  N-(2,3-diphenylpropyl)acetamide | C17H19NO | 253.345 | 1 / 1 | 3.2 | Yes |
| 40096 |  CHEMBL233516 | C16H22N2O2 | 274.364 | 2 / 1 | 2.4 | Yes |
| 41205 |  CHEMBL99534 | C12H14N2O2 | 218.256 | 2 / 2 | 1.2 | Yes |
| 468005 |  CHEMBL3628489 | C14H15NO4 | 261.277 | 4 / 1 | 1.0 | Yes |
| 42159 |  CHEMBL514280 | C24H29NO2 | 363.501 | 2 / 1 | 4.9 | Yes |
| 42736 |  CHEMBL478438 | C25H27NO3 | 389.495 | 3 / 2 | 4.5 | Yes |
| 43864 |  CHEMBL99000 | C14H18N2O2 | 246.31 | 2 / 2 | 2.0 | Yes |
| 43946 |  CHEMBL132802 | C17H19NO2 | 269.344 | 2 / 1 | 2.9 | Yes |
| 44112 |  beta-methylmelatonin | C14H18N2O2 | 246.31 | 2 / 2 | 1.9 | Yes |
| 44403 |  CHEMBL1092647 | C19H23NO3 | 313.397 | 3 / 1 | 3.1 | Yes |
| 44531 |  CHEMBL33172 | C21H21ClN2O | 352.862 | 1 / 2 | 4.9 | Yes |
| 443459 |  CHEMBL3329369 | C13H17NO2 | 219.284 | 3 / 2 | 1.9 | Yes |
| 45700 |  CHEMBL1813319 | C26H38N4O4 | 470.614 | 6 / 2 | 3.1 | Yes |
| 46186 |  CHEMBL269175 | C20H20N2O | 304.393 | 1 / 1 | 3.4 | Yes |
| 443505 |  CHEMBL3329374 | C14H17NO2 | 231.295 | 3 / 0 | 2.4 | Yes |
| 46651 |  7-Azamelatonin | C12H15N3O2 | 233.271 | 3 / 2 | 0.9 | Yes |
| 46962 |  CHEMBL1091896 | C21H27NO3 | 341.451 | 3 / 1 | 4.1 | Yes |
| 47526 |  CHEMBL14417 | C38H48N2O4 | 596.812 | 4 / 2 | 8.8 | No |
| 47988 |  CHEMBL19123 | C18H26N2O2 | 302.418 | 3 / 0 | 2.3 | Yes |
| 48540 |  CHEMBL521826 | C16H20N2O4 | 304.346 | 4 / 2 | 2.5 | Yes |
| 48839 |  CHEMBL1760951 | C17H24N4O3 | 332.404 | 5 / 1 | 0.3 | Yes |
| 49879 |  CHEMBL1813323 | C32H50N4O4 | 554.776 | 6 / 2 | 6.0 | No |
| 51139 |  CHEMBL494566 | C18H21NO4 | 315.369 | 4 / 1 | 3.3 | Yes |
| 51775 |  CHEMBL233517 | C20H22N2O2 | 322.408 | 2 / 2 | 3.7 | Yes |
| 52011 |  CHEMBL125642 | C16H20N2O2 | 272.348 | 3 / 1 | 3.0 | Yes |
| 52689 |  CHEMBL3219325 | C25H27N3O2 | 401.51 | 2 / 2 | 4.3 | Yes |
| 53442 |  CHEMBL359561 | C25H31N3O2 | 405.542 | 3 / 2 | 5.3 | No |
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