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| Name | Endothelin-1 receptor |
|---|---|
| Species | Sus scrofa (Pig) |
| Gene | EDNRA |
| Synonym | Endothelin receptor type A {ECO:0000250|UniProtKB:P25101} ET-A ET-AR |
| Disease | N/A for non-human GPCRs |
| Length | 427 |
| Amino acid sequence | METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN |
| UniProt | Q29010 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | N/A |
| 3D structure model | No available structures or models |
| BioLiP | N/A |
| Therapeutic Target Database | N/A |
| ChEMBL | CHEMBL4130 |
| IUPHAR | N/A |
| DrugBank | N/A |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 48 |  CHEMBL304260 | C49H61N7O10 | 908.066 | 10 / 9 | 4.7 | No |
| 771 |  CHEMBL116108 | C31H31N5O5S | 585.679 | 10 / 1 | 6.0 | No |
| 3686 |  CHEMBL72891 | C31H46BrN5O5S | 680.703 | 6 / 5 | 6.0 | No |
| 4056 |  CHEMBL113757 | C28H31N5O5S | 549.646 | 10 / 1 | 5.3 | No |
| 4575 |  CHEMBL2304007 | C33H44N6O7 | 636.75 | 7 / 6 | 2.7 | No |
| 5098 |  CHEMBL114700 | C27H28BrN5O6S | 630.514 | 11 / 1 | 5.7 | No |
| 8512 |  CHEMBL324304 | C23H27N3O4S | 441.546 | 7 / 2 | 4.3 | Yes |
| 10110 |  CHEMBL430515 | C29H33N5O6S | 579.672 | 11 / 1 | 5.7 | No |
| 12853 |  BDBM50287884 | C73H97N15O21 | 1520.66 | 22 / 19 | 2.3 | No |
| 13464 |  CHEMBL31436 | C25H37N5O5 | 487.601 | 5 / 6 | 2.2 | No |
| 15195 |  CHEMBL77083 | C31H45N5O5 | 567.731 | 5 / 5 | 4.7 | No |
| 18185 |  CHEMBL263186 | C55H65N7O10 | 984.164 | 10 / 9 | 6.7 | No |
| 20371 |  CHEMBL404763 | C30H42N6O7 | 598.701 | 7 / 7 | 2.1 | No |
| 20894 |  CHEMBL342615 | C30H42N6O8S | 646.76 | 8 / 6 | 1.6 | No |
| 22515 |  CHEMBL2304014 | C31H39N7O7 | 621.695 | 8 / 6 | 1.9 | No |
| 22785 |  CHEMBL281963 | C26H36N4O7 | 516.595 | 7 / 6 | 1.9 | No |
| 22903 |  CHEMBL308621 | C32H45N7O5 | 607.756 | 6 / 6 | 4.0 | No |
| 24013 |  CHEMBL168904 | C30H34BrN5O4S | 640.597 | 9 / 1 | 7.2 | No |
| 24931 |  CHEMBL3301647 | C30H40N6O7 | 596.685 | 7 / 6 | 3.0 | No |
| 24932 |  CHEMBL138067 | C30H40N6O7 | 596.685 | 7 / 6 | 3.0 | No |
| 27055 |  CHEMBL112502 | C25H27N5O5S2 | 541.641 | 11 / 1 | 4.6 | No |
| 28478 |  CID 44314819 | C73H97N15O21 | 1520.66 | 22 / 19 | 2.3 | No |
| 30605 |  CHEMBL77853 | C30H42BrN5O5 | 632.6 | 5 / 5 | 5.6 | No |
| 33551 |  CHEMBL133257 | C33H44N6O7 | 636.75 | 7 / 6 | 2.7 | No |
| 36909 |  CHEMBL64271 | C51H65N7O10 | 936.12 | 10 / 9 | 6.1 | No |
| 443204 |  CHEMBL407831 | C51H63N7O12 | 966.102 | 12 / 10 | 4.6 | No |
| 38608 |  CHEMBL114704 | C31H31N5O6S | 601.678 | 11 / 1 | 5.8 | No |
| 39523 |  CHEMBL284785 | C27H41N5O6 | 531.654 | 6 / 6 | 1.4 | No |
| 39669 |  CHEMBL135906 | C29H40N6O8 | 600.673 | 8 / 8 | 1.4 | No |
| 39766 |  CHEMBL287980 | C36H48N7O6- | 674.823 | 7 / 3 | 4.2 | No |
| 40368 |  CHEMBL408616 | C52H63N9O10 | 974.129 | 11 / 10 | 4.9 | No |
| 40976 |  CHEMBL323243 | C27H28ClN5O4S | 554.062 | 9 / 1 | 5.9 | No |
| 42777 |  CHEMBL170493 | C32H31BrN6O4S | 675.602 | 10 / 1 | 6.6 | No |
| 43380 |  CID 23427740 | C34H27Br4N4NaO11S | 1042.27 | 13 / 5 | N/A | No |
| 44690 |  CHEMBL74471 | C36H45BrN6O5 | 721.697 | 5 / 6 | 6.5 | No |
| 47003 |  CHEMBL2370830 | C32H44N6O7 | 624.739 | 7 / 6 | 2.5 | No |
| 49606 |  CHEMBL321242 | C27H29N5O4S | 519.62 | 9 / 1 | 5.3 | No |
| 51304 |  CHEMBL114201 | C27H29N5O6S | 551.618 | 11 / 1 | 5.0 | No |
| 54343 |  CHEMBL77033 | C30H44BrN5O5 | 634.616 | 5 / 5 | 5.7 | No |
| 54702 |  CHEMBL336087 | C29H41N5O8 | 587.674 | 8 / 6 | 1.7 | No |
| 54953 |  CHEMBL307324 | C32H44N6O7 | 624.739 | 7 / 5 | 2.4 | No |
| 54954 |  CHEMBL138120 | C32H44N6O7 | 624.739 | 7 / 5 | 2.4 | No |
| 56035 |  CHEMBL287888 | C33H51N5O5 | 597.801 | 5 / 5 | 6.0 | No |
| 56037 |  CHEMBL405724 | C33H51N5O5 | 597.801 | 5 / 5 | 6.0 | No |
| 56992 |  CHEMBL326380 | C31H31N5O4S2 | 601.74 | 10 / 1 | 6.6 | No |
| 57043 |  CHEMBL409808 | C51H64N8O11 | 965.118 | 11 / 10 | 3.9 | No |
| 62826 |  CHEMBL2304018 | C30H39ClN6O7 | 631.127 | 7 / 6 | 2.8 | No |
| 63513 |  CHEMBL170663 | C30H36BrN7O6S | 702.625 | 13 / 3 | 5.4 | No |
| 63673 |  CHEMBL332922 | C29H33N5O4S2 | 579.734 | 10 / 1 | 6.3 | No |
| 64027 |  CHEMBL311134 | C31H41N7O5 | 591.713 | 6 / 6 | 3.0 | No |
| 64263 |  CHEMBL335128 | C37H45N7O7 | 699.809 | 7 / 8 | 3.6 | No |
| 68433 |  CHEMBL116046 | C28H31N5O4S2 | 565.707 | 10 / 1 | 5.8 | No |
| 68651 |  CHEMBL287676 | C28H35N5O5 | 521.618 | 5 / 6 | 3.3 | No |
| 69355 |  CHEMBL312541 | C33H42N6O7 | 634.734 | 7 / 6 | 2.1 | No |
| 72003 |  CHEMBL343959 | C26H39N7O7 | 561.64 | 8 / 6 | 0.2 | No |
| 78208 |  CHEMBL343768 | C29H40N6O7S | 616.734 | 8 / 8 | 1.8 | No |
| 78945 |  CHEMBL405100 | C51H65N7O10S | 968.18 | 11 / 9 | 5.7 | No |
| 81147 |  CHEMBL262947 | C55H65N7O11 | 1000.16 | 11 / 10 | 6.3 | No |
| 83041 |  CHEMBL438022 | C63H71N7O10 | 1086.3 | 10 / 9 | 8.4 | No |
| 83823 |  CHEMBL287141 | C26H38N4O5 | 486.613 | 5 / 5 | 2.7 | Yes |
| 84434 |  CHEMBL166875 | C28H30BrN5O6S | 644.541 | 11 / 1 | 5.9 | No |
| 84909 |  CHEMBL112134 | C27H22BrN5O4S | 592.468 | 9 / 1 | 5.6 | No |
| 89582 |  CHEMBL62514 | C46H57N7O9 | 852.002 | 9 / 9 | 4.2 | No |
| 89626 |  CHEMBL410694 | C50H62N8O11 | 951.091 | 11 / 10 | 3.6 | No |
| 90280 |  CHEMBL113927 | C28H31N5O6S | 565.645 | 11 / 1 | 5.2 | No |
| 91515 |  CHEMBL420501 | C26H28N6O4S2 | 552.668 | 11 / 1 | 4.4 | No |
| 92289 |  CHEMBL302776 | C29H40N6O7 | 584.674 | 7 / 7 | 1.9 | No |
| 92290 |  CHEMBL335143 | C29H40N6O7 | 584.674 | 7 / 7 | 1.9 | No |
| 96462 |  CHEMBL177373 | C27H24BrN5O5S | 610.483 | 10 / 2 | N/A | No |
| 97377 |  CHEMBL362276 | C28H31N5O5S | 549.646 | 10 / 1 | 5.3 | No |
| 97814 |  CHEMBL2373085 | C51H63N7O10 | 934.104 | 10 / 8 | 5.4 | No |
| 98128 |  Bosentan | C27H29N5O6S | 551.618 | 11 / 2 | 3.8 | No |
| 98610 |  CHEMBL177924 | C26H28BrN5O5S | 602.504 | 10 / 2 | N/A | No |
| 101151 |  CHEMBL136871 | C31H30BrN5O4S2 | 680.636 | 10 / 1 | 7.4 | No |
| 101357 |  CHEMBL405916 | C55H65N7O11 | 1000.16 | 11 / 10 | 6.3 | No |
| 103209 |  CHEMBL308584 | C31H47N5O5S | 601.807 | 6 / 5 | 4.8 | No |
| 103645 |  CHEMBL151064 | C25H24ClNO6 | 469.918 | 7 / 2 | 2.6 | Yes |
| 104393 |  CHEMBL31388 | C27H39N5O5 | 513.639 | 5 / 5 | 2.3 | No |
| 107042 |  CHEMBL412602 | C31H46ClN5O5 | 604.189 | 5 / 5 | 6.2 | No |
| 107043 |  CHEMBL289410 | C31H46ClN5O5 | 604.189 | 5 / 5 | 6.2 | No |
| 109914 |  CHEMBL335126 | C28H36N6O10 | 616.628 | 10 / 9 | -0.5 | No |
| 110205 |  CHEMBL308403 | C30H44BrN5O5S | 666.676 | 6 / 5 | 5.5 | No |
| 111248 |  CHEMBL343062 | C30H40N6O7S | 628.745 | 8 / 6 | 2.2 | No |
| 111314 |  CHEMBL77468 | C31H46BrN5O5 | 648.643 | 5 / 5 | 6.3 | No |
| 112050 |  CHEMBL31051 | C28H35N5O5 | 521.618 | 5 / 6 | 2.4 | No |
| 112433 |  CHEMBL31546 | C30H37N5O5 | 547.656 | 5 / 5 | 3.1 | No |
| 112461 |  CHEMBL2304012 | C32H41BrN6O7 | 701.619 | 7 / 6 | 3.3 | No |
| 114618 |  CHEMBL341751 | C28H36N6O7 | 568.631 | 7 / 6 | 0.8 | No |
| 114619 |  CHEMBL308208 | C28H36N6O7 | 568.631 | 7 / 6 | 0.8 | No |
| 115946 |  CHEMBL136210 | C35H44N6O7 | 660.772 | 7 / 7 | 3.5 | No |
| 117713 |  CHEMBL420132 | C27H28ClN5O4S2 | 586.122 | 10 / 1 | 6.1 | No |
| 117825 |  CHEMBL1791007 | C31H42N6O7 | 610.712 | 7 / 6 | 2.2 | No |
| 118013 |  CHEMBL386778 | C51H63N7O12 | 966.102 | 12 / 10 | 4.6 | No |
| 118197 |  CHEMBL407639 | C29H40N6O10S | 664.731 | 10 / 8 | 0.4 | No |
| 118219 |  CHEMBL175523 | C29H33N5O6S2 | 611.732 | 12 / 1 | 5.4 | No |
| 119920 |  CHEMBL216772 | C68H98N14O21 | 1447.61 | 22 / 18 | 1.9 | No |
| 120882 |  CHEMBL2304010 | C31H41ClN6O7S | 677.214 | 8 / 6 | 2.7 | No |
| 121901 |  CHEMBL262993 | C52H67N7O10 | 950.147 | 10 / 9 | 6.4 | No |
| 121905 |  PD 145065 | C52H67N7O10 | 950.147 | 10 / 9 | 6.4 | No |
| 123746 |  CHEMBL408574 | C48H59N7O10 | 894.039 | 10 / 9 | 4.3 | No |
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