GPCR-I-TASSER results for P32247

[Click on P32247_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>P32247
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL
PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT
YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT
SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSCCCCCCSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCC
Conf.Score998889999867534567887766667788776555666676626899899999999999988888541421507988859899999999999999999888999999838888965888889999999999999999999998588865115234040378688866899999999999999981788711589862589851668857799999999999999999999999999999999952678888631056889888553899999999999999989999999999985312578138999999999999999999999999973999999999995525668858987777876633446778998750244014567777654356899

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
Prediction754444433221122221333322322333323332333331301011110210010022033233210000000241210121530230001000000011000010024300222011000000010000000001001001021000100212331121100000000010000000000001001324344431000000110234510210010011332331100000200010001013233535454444444334411000000000000000130010000001000322214311000001010000000100131302000044024001100210333345443453433333344444343334334333333333434536558
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=0.05
 C-score=-1.03
 C-score=-2.29
 C-score=-1.39
 C-score=-0.46
 
Estimated accuracy of Model1: 0.72±0.11 (TM-score)    6.7±4.0Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSCCCCCCSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCCCCCCCCCCCCCCC
MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
12ks9A 0.22 0.22 0.91 3.91Download ------------DNVLPVDSDLSP----NISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLS--ATATKVVICVIWVLALLLAFPQGYYSTTETMPSR-----VVCMIEWPEPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH--EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCP----FISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA------
22rh1A 0.25 0.24 0.73 2.94Download ------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQHWYRATH-----QEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNRIDEGGEWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-I-----RKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL----------------------------------------------------
32ks9A 0.22 0.22 0.91 3.50Download ----------------DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVICVIWVLALLLAFPQGYYSTTETMPSR-----VVCMIEWPEPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH--EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGD-YEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA---------
42ks9A 0.21 0.22 0.91 5.36Download ----------------DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRV-----VCMIEWPEPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSD--RYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA----------
52ks9A 0.21 0.22 0.91 4.34Download ----------------DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV----CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH--EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA----------
64ea3B 0.30 0.22 0.68 5.28Download ------------------------------------------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAE----------IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLEKD----------------RNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGV---QPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKF-------------------------------------------------------
74grvA 0.20 0.20 0.75 3.38Download ---------------------------------NS-DLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARK----STVHYHLGSLALSDLLILLLAMPVELYNFIHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIV--DTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVNIFPSQWDAYGSGSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFYHYFYMLTNALAYASSAINPILYNLVSANFRQV-----------------------------------------------------------
82ks9A 0.21 0.22 0.8910.67Download -----------------NVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRL--SATATKVVICVIWVLALLLAFPQGYYSTTETMP------SRVVCMIEWPEHI-YEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGD--SSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPD--LYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYK-VSRLETTIST-------------
92ks9A 0.21 0.22 0.91 4.21Download ----------------DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC----MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH--EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA----------
102ks9A 0.21 0.22 0.90 4.30Download -----------------NVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPR--LSATATKVVICVIWVLALLLAFPQGYYSTTETM-----PSRVVCMIEWPEPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIP--GDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKK--FIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA----------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on P32247_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted, 2015.