GPCR-I-TASSER results for O00325

[Click on O00325_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>O00325
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQM
RKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
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MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCSSSSSCCCCCCCCHHHHHHHHHHSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score988878999988778888777777789888787888688998741156999999999999999999999997653121578877640899999999999999999899999999757905288997884150999999999999999999999988771300313667477467752449999999999999871434798679718997546888764157789878714189999999999999999999999997404666665543367788999999876388776899899999999999715455672023234446579999999999999996999996099999999998154468877799999988677889987567898887654579

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
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MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
Prediction454244353321212331112222233343343432313123334200000022123113303301210000001022234343311000000200300021020110000000024230100200210001001011100100010000000000000000020243022200000000000000100110100002123444211000001233323322310000010111222332232112100000000003324544444543443342301000000000000021204210100000002221331322233302100000000101131031001202227621422141031204446445744334434443344444664443343447
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |  
Sec.Str
Seq
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCSSSSSCCCCCCCCHHHHHHHHHHSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
11gzmA 0.16 0.19 0.80 3.94Download ----------------MNGTEGPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRT-----PLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-FVFGP---TGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPH-----EETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQ----QESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGP----------IFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKN---DD-------------------------------
24n6hA 0.17 0.19 0.75 3.25Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTA-----TNIYIFNLALADALATST-LPFQSAKYLMET-WPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-GAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG------------------------------------
34n6hA 0.16 0.19 0.75 2.70Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKT-----ATNIYIFNLALADALATSTLPFQSAKYLM---TWPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVM-AVTRPRDGAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS-----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG------------------------------------
42rh1A 0.15 0.19 0.73 2.57Download -------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKF-----ERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM-KMWTF---GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMWYRA-THQEAINCYAEETC------CDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMKTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK-----------EVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL---------------------------------------
54buoA 0.17 0.17 0.73 1.92Download -----------------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKS---TVD-----YYLGSLALSDLLILLLAMPVELYNFIVHHPWAFGDA---GCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSPGGLVCTP-IV--------DTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQ--------PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWT---TFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL-----------------------------------------
64n6hA 0.17 0.19 0.75 3.21Download -------------------------------------GARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKT-----ATNIYIFNLALADALA-TSTLPFQSAKYLME-TWPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-GAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG-----SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG------------------------------------
74buoA 0.17 0.17 0.74 2.81Download -----------------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQ--S---TVDYYLGSLALSDLLILLLAMPVELYNFIWV--HHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLHPGGLVCTPI---------VDTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQ--------PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQW---TTFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL-----------------------------------------
81u19A 0.17 0.20 0.86 4.64Download MN-----------GTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRT-----PLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-FVF---GPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPM-SNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETN-----NESFVIYMFVVHFIIPLIVIFFCYGQLVF----TVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFG----------PIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEA----------------STTVSKTETSQVA
94n6hA 0.16 0.19 0.75 2.71Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTA-----TNIYIFNLALADALATSTLPFQSAKYLM--ETWPFGEL---LCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVM-AVTRPRDGAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSG-----SKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG------------------------------------
101l9hA 0.16 0.19 0.85 3.80Download MNGTEG-----------PNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRT-----PLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-FVFGPT---GCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR-FGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETN-----NESFVIYMFVVHFIIPLIVIFFCYGQLVFTV---------KEAAAATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFG----------PIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDSTTVSKT-----------------ETSQVAPA
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.68 (Read more about C-score)
  • Estimated TM-score = 0.63±0.14
  • Estimated RMSD = 8.4±4.5Å

  • Download Model 2
  • C-score = -2.30

  • Download Model 3
  • C-score = -1.20

  • Download Model 4
  • C-score = -3.71

  • Download Model 5
  • C-score = -1.67





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).