GPCR-I-TASSER results for Q2YD89

[Click on Q2YD89_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q2YD89
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCCMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCCMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
PredictionCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSSCCCCSSSSSCCCCCHHHHHHHHCSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score99888884201668999999999999999999873343211778898359999999999999999988999999981334105315987800149999999999999999999998688833446457670787888999999999999999887444248996899579861789961414354103566299899999999999999999987662234443420567789998986004688999999899999999999688765369999999999999999999999978999999999813478899877777888887788888888887534678877888888788189997678999836887767666568789

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCCMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
Prediction72440533330310000211221032123033202100002233242000000002010100102111210000002322011201101000000010110001000100000000000000100202330222100000000002001002201100011233442110000032432210000101123233332212200000000000123334434444444443343112000000000200000310000000000011331220000201110101033422221001640041024002000324444446344344334444443444434453433425433534344333645343313323344433331432
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |      
Sec.Str
Seq		CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSSSCCCCSSSSSCCCCCHHHHHHHHCSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCCMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
11gzmA 0.17 0.18 0.75 3.67Download -----------QFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLR-TPLNYILLNLAVADLFMVFGGFTTTLYTSLH-----GYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR-FGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHENESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKE-------AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKN---DD---------------------------------------------------------------------
22ziyA 0.13 0.17 0.89 2.76Download IVHEFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQ-TPANMFIINLAFSDFTFSLVNFPLMTISCFL-----KKWIFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFDYISRDSTTRSNILCMFILFFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVLTCCQFDDKETEDDKDAET----EIPAGESSDAAPSADAAQMKE--------------------------------
34n6hA 0.16 0.19 0.77 3.13Download SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK-TATNIYIFNLALADALATST-LPFQSAKYLMET-----WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMA-VTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------------------------------------------
44n6hA 0.16 0.19 0.77 2.63Download SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK-TATNIYIFNLALADALATSTLPFQSAKYLME------TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV-MAVTRPRDGAVVCMLQFPSPSWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------------------------------------------
52rh1A 0.15 0.21 0.76 2.54Download --------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQ-TVTNYFITSLACADLVMGLAVVPFGAAHILMKM-----WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFTNQAYAIASIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRKTTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-----------------------------------------------------------------------------
64iarA 0.15 0.17 0.74 1.95Download ----QDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLH-TPANYLIASLAVTDLLVSILVMPISTMYTV-----TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA------SECVVNT--D---HILYVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDDDSPGYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI---WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK----------------------------------------------------------------------------
74n6hA 0.16 0.19 0.76 3.13Download --GARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK-TATNIYIFNLALADALA-TSTLPFQSAKYLMET-----WPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV-MAVTRPRDGAVVCMLQFPSPSWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------------------------------------------
84iarA 0.16 0.17 0.73 2.86Download ---------YIYKVLLVMLLALITLATTLSNAFVIATVYRTRKLH-TPANYLIASLAVTDLLVSILVMPISTMYTVTGRW-----TLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA------SECVVNT--DH---ILYTVYTVGAFYFPTLLLIALYGRIYVEARSRIADLEDEDDSPGIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI---WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK----------------------------------------------------------------------------
91u19A 0.16 0.19 0.83 4.42Download VVRSPFEAPPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLR-TPLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-----FVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRF-GENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHENESFVIYMFVVHFIIPLIVIFFCYGQLVFTV-------KEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA----------------------------------------------------
104n6hA 0.16 0.19 0.76 2.81Download -SPGARSSSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK-TATNIYIFNLALADALATSTLPFQSAKYLME------TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV-MAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFVVPILIITVCYGLMLLRLRSV--------RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG--------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: wdPPAS   3: SPARKS-X   4: MUSTER   5: HHSEARCH2   6: HHSEARCH I   7: Neff-PPAS   8: HHSEARCH   9: pGenTHREADER   10: wdPPAS   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.64 (Read more about C-score)
  • Estimated TM-score = 0.63±0.13
  • Estimated RMSD = 8.2±4.5Å

  • Download Model 2
  • C-score = -3.18

  • Download Model 3
  • C-score = -2.43

  • Download Model 4
  • C-score = -4.00

  • Download Model 5
  • C-score = -4.06




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).