GPCR-I-TASSER results for Q5CZ62

[Click on Q5CZ62_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q5CZ62
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQV
ANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSS
HDREPCSVQLS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
PredictionCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCSSSSSSSCCCCSSSSSCCCCCCCCHHHHHHHHHHSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score99888899998877878877776778888888788867899875203689989999999999999999989765303157787774089999999999999999989999999975792548898777205098999999999999999999997887240031355747756776576999999999999987043379757984799853678876414778987875635899999999999999999999999731355666653257788999999999999999999989999999999975645577203334556778999999999999999999999639999999999825136877777778987767777777655567667788889999986678888865454456897442569

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
Prediction36433334331122232211231222323334342222312333420000001212311230231121000000102223434331100000001010100002001000000002422010020021000000101110010001000000000000000002024202210000000000000010011010000112344432100000123322221220000001011123213200100120000000100332354544554344334230100000000000001130332010000000212133132223330210000000000102003101220322661041014003122413445446444443454344533444433456336545331522441333223341442043528
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
Sec.Str
Seq		CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCSSSSSSSCCCCSSSSSCCCCCCCCHHHHHHHHHHSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQVANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS
12ks9A 0.15 0.18 0.84 3.87Download -----------------DNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRT-----VTNYFLVNLAFAEASMAAFNTVVNFTYAVHNE-WYYGL---FYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPL--QPRLSATATKVVICVIWVLALLLAF-PQGYYSTTETMPSRVVCMIEWPEHPNKI-----YEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQ-VSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLK-------KFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA--------------------------
24n6hA 0.17 0.18 0.70 3.15Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMK-----TATNIYIFNLALADALATST-LPFQSAKYLME-TWPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMA-VTRPRDGAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
34n6hA 0.16 0.18 0.70 2.56Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTA-----TNIYIFNLALADALATSTLPFQSAKYLM---TWPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVM-AVTRPRDGAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS-----KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
42rh1A 0.16 0.19 0.68 2.54Download -------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKF-----ERLQTVTNYFITSLACADLVMGLAVVPFGAAHILM-KMWTF---GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMWYRAT-HQEAINCYAEETC------CDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMKTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK-----------EVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLC----L----------------------------------------------------------------
54buoA 0.17 0.16 0.68 1.92Download -----------------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKS---TVD-----YYLGSLALSDLLILLLAMPVELYNFIVHHPWAFGDA---GCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSPGGLVCTP-IV--------DTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQ--------PGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWT---TFLFDFYHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL----------------------------------------------------------------------
64n6hA 0.17 0.18 0.70 3.13Download -------------------------------------GARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKT-----ATNIYIFNLALADALA-TSTLPFQSAKYLME-TWPFG---ELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD-GAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
72rh1A 0.17 0.19 0.68 2.76Download -------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQ-----TVTNYFITSLACADLVMGLAVVPFGAAHILMK-MWTF---GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMWYRAT-HQEAINCYAEETCCDFFT------NQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEKGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL-----------IRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL--------------------------------------------------------------------
81u19A 0.17 0.19 0.80 4.44Download ----------------MNNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRT-----PLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-FVF---GPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPM-SNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETN-----NESFVIYMFVVHFIIPLIVIFFCYGQLVF----TVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFG----------PIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA-------------------------------------------
94n6hA 0.16 0.18 0.70 2.67Download -----------------------------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTA-----TNIYIFNLALADALATSTLPFQSAKYLM--ETWPFGEL---LCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMV-MAVTRPRDGAVVCMLQFPSP------SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRD-------PLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG-----------------------------------------------------------------
101l9hA 0.17 0.19 0.79 3.70Download MNGTEGPNFYVPFSNK-----------TGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRT-----PLNYILLNLAVADLFMVFGGFTTTLYTSLHGY-FVFGPT---GCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR-FGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETN-----NESFVIYMFVVHFIIPLIVIFFCYGQLVFTV---------KEAAAATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFG----------PIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDSTTVSKTETSQVAP----------------------------------------------A
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-1.65 (Read more about C-score)
  • Estimated TM-score = 0.51±0.15
  • Estimated RMSD = 10.8±4.6Å

  • Download Model 2
  • C-score = -1.73

  • Download Model 3
  • C-score = -2.52

  • Download Model 4
  • C-score = -3.24

  • Download Model 5
  • C-score = -3.24




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).