GPCR-I-TASSER results for Q8NGQ1

[Click on Q8NGQ1_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q8NGQ1
MIFPSHDSQAFTSVDMEVGNCTILTEFILLGFSADSQWQPILFGVFLMLYLITLSGNMTL
VILIRTDSHLHTPMYFFIGNLSFLDFWYTSVYTPKILASCVSEDKRISLAGCGAQLFFSC
VVAYTECYLLAAMAYDRHAAICNPLLYSGTMSTALCTGLVAGSYIGGFLNAIAHTANTFR
LHFCGKNIIDHFFCDAPPLVKMSCTNTRVYEKVLLGVVGFTVLSSILAILISYVNILLAI
LRIHSASGRHKAFSTCASHLISVMLFYGSLLFMYSRPSSTYSLERDKVAALFYTVINPLL
NPLIYSLRNKDIKEAFRKATQTIQPQT

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
MIFPSHDSQAFTSVDMEVGNCTILTEFILLGFSADSQWQPILFGVFLMLYLITLSGNMTLVILIRTDSHLHTPMYFFIGNLSFLDFWYTSVYTPKILASCVSEDKRISLAGCGAQLFFSCVVAYTECYLLAAMAYDRHAAICNPLLYSGTMSTALCTGLVAGSYIGGFLNAIAHTANTFRLHFCGKNIIDHFFCDAPPLVKMSCTNTRVYEKVLLGVVGFTVLSSILAILISYVNILLAILRIHSASGRHKAFSTCASHLISVMLFYGSLLFMYSRPSSTYSLERDKVAALFYTVINPLLNPLIYSLRNKDIKEAFRKATQTIQPQT
PredictionCCCCCCCCCCCCHHHCCCCCCCCCCSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSCCCCCCCCCHHCCHHHHHHHHHHHHHHHCSSSSCCCCCCCCCCCCSSSSSSCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCC
Conf.Score977754445460543126788512012586489992518999999999999999999899999950887667498887679988447102571999999724897885899999999999999999999999986514520611018801678899999999999999999999999855128899905864158288887625786277888999999999999999999999999998025676766542106588899799997433034817899988888988998822103124356440465989999999998524789

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
MIFPSHDSQAFTSVDMEVGNCTILTEFILLGFSADSQWQPILFGVFLMLYLITLSGNMTLVILIRTDSHLHTPMYFFIGNLSFLDFWYTSVYTPKILASCVSEDKRISLAGCGAQLFFSCVVAYTECYLLAAMAYDRHAAICNPLLYSGTMSTALCTGLVAGSYIGGFLNAIAHTANTFRLHFCGKNIIDHFFCDAPPLVKMSCTNTRVYEKVLLGVVGFTVLSSILAILISYVNILLAILRIHSASGRHKAFSTCASHLISVMLFYGSLLFMYSRPSSTYSLERDKVAALFYTVINPLLNPLIYSLRNKDIKEAFRKATQTIQPQT
Prediction630333536423444035403030010000000432301000013033313212332310010010003000000100200001001000000020001002542201010000001000000200000000000000000011120203003300000012011101300301011003030044120100000321003000131311011001101322331231033033100100010303622310000101021001023201100000031431344410000010321023003000021320140032004323668
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |       
Sec.Str
Seq
CCCCCCCCCCCCHHHCCCCCCCCCCSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSCCCCCCCCCHHCCHHHHHHHHHHHHHHHCSSSSCCCCCCCCCCCCSSSSSSCCCHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCC
MIFPSHDSQAFTSVDMEVGNCTILTEFILLGFSADSQWQPILFGVFLMLYLITLSGNMTLVILIRTDSHLHTPMYFFIGNLSFLDFWYTSVYTPKILASCVSEDKRISLAGCGAQLFFSCVVAYTECYLLAAMAYDRHAAICNPLLYSGTMSTALCTGLVAGSYIGGFLNAIAHTANTFRLHFCGKNIIDHFFCDAPPLVKMSCTNTRVYEKVLLGVVGFTVLSSILAILISYVNILLAILRIHSASGRHKAFSTCASHLISVMLFYGSLLFMYSRPSSTYSLERDKVAALFYTVINPLLNPLIYSLRNKDIKEAFRKATQTIQPQT
14iaqA 0.17 0.19 0.84 2.09Download ---------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISL-------PPFFWRQAS--------------ECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIIQKMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK----
23emlA 0.20 0.22 0.85 3.58Download -----------------------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS---GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAI-IVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
33uonA 0.17 0.20 0.84 2.51Download -----------------------------------TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV--GVRTVEDGECYIQFF------S---NAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINISREKKVTRTILAILLAFIITWAPYNVMVLINTFCCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLM------
44bvnA 0.16 0.20 0.84 2.08Download ---------------------------------LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMM----HWWRDEDPQALKCYQD----PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE----MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA------
53emlA 0.21 0.22 0.85 3.93Download ------------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCF-TFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
64bvnA 0.16 0.20 0.84 3.00Download ----------------------------------SQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWR----DEDPQALKCYQDP----GCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE----MREHKALKTLGIIMGVFTLCWLPFFLVNIVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA------
74ea3A 0.17 0.18 0.80 2.92Download ----------------------------------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLT-LPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEIECLVEIPTPQDYWGPVFAICIFLFSF-----------------IVPVLVISVCYSLMIRRLRGVRLLSGSVAVFVGCWTPVQVFVLAQGLG-----VQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFR----------
83emlA 0.20 0.22 0.85 5.69Download -----------------------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS---GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAI-IVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
93emlA 0.22 0.22 0.85 5.47Download I-----------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPL-----------LLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALC-WLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
103emlA 0.19 0.22 0.82 2.85Download ------------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEGQVACLFEDV--------VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQ-----LVHAAKSLAIIVGLFALCWLPLHIINCFTFFCHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKI--------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: MUSTER   3: HHSEARCH2   4: HHSEARCH I   5: Neff-PPAS   6: HHSEARCH   7: pGenTHREADER   8: wdPPAS   9: PROSPECT2   10: PRC   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.77 (Read more about C-score)
  • Estimated TM-score = 0.62±0.14
  • Estimated RMSD = 8.1±4.4Å

  • Download Model 2
  • C-score = -1.38

  • Download Model 3
  • C-score = -3.17

  • Download Model 4
  • C-score = -1.99

  • Download Model 5
  • C-score = -0.85





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).