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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
GPCR-RD Home

GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
mc4r_human D126N  [Orientation Restraint] mc4r_human D126S  [Orientation Restraint] mc4r_human S127L  [Orientation Restraint]
mc4r_human C130A  [Orientation Restraint] mc4r_human T150I mc4r_human A154D
mc4r_human Y157S mc4r_human K164A mc4r_human R165A
mc4r_human R165Q mc4r_human R165W mc4r_human S190A
mc4r_human S191A mc4r_human C196A  [Orientation Restraint] mc4r_human T199A  [Orientation Restraint]
mc4r_human F202L  [Orientation Restraint] mc4r_human M204A  [Orientation Restraint] mc4r_human N240S
mc4r_human A244E mc4r_human L250Q  [Orientation Restraint] mc4r_human I251L  [Orientation Restraint]
mc4r_human W258A  [Orientation Restraint] mc4r_human F261A  [Orientation Restraint] mc4r_human F262A  [Orientation Restraint]
mc4r_human Y268A mc4r_human C271A mc4r_human C271T
mc4r_human C271Y mc4r_human N274S mc4r_human F284A  [Orientation Restraint]
mc4r_human N285A  [Orientation Restraint] mc4r_human S295P  [Orientation Restraint] mc4r_human D298A  [Orientation Restraint]
mc4r_human P299H  [Orientation Restraint] mc4r_human I301T  [Orientation Restraint] mc4r_human R305A
mc4r_human S306A mc4r_human R310A mc4r_human K311A
mc4r_human T312A mc4r_human F313A mc4r_human K314A
mc4r_human E315A mc4r_human I316A mc4r_human I316T
mc4r_human I317A mc4r_human I317T mc4r_human S329A
mc4r_human S330A mc4r_mouse Q43X mc4r_mouse T112M
mc4r_mouse I317T mc4r_mouse I317V mc4r_rat Y268I
mc4r_rat S270T mc4r_rat Q273T mc4r_rat M281T
mc5r_human Q235K mc5r_human R272C mtr1a_human S6K
mtr1a_human R54W mtr1a_human M107D  [Orientation Restraint] mtr1a_human M107T  [Orientation Restraint]
mtr1a_human N124A mtr1a_human N124D mtr1a_human N124E
mtr1a_human N124K mtr1a_human N124L mtr1a_human C127S
mtr1a_human C130S mtr1a_human V192A  [Orientation Restraint] mtr1a_human V192T  [Orientation Restraint]
mtr1a_human H195A  [Orientation Restraint] mtr1a_human P253A  [Orientation Restraint] mtr1b_human S123A  [Orientation Restraint]
mtr1b_human S127A  [Orientation Restraint] mtr1b_human S127N  [Orientation Restraint] mtr1b_human H208A  [Orientation Restraint]
mtr1b_human H208F  [Orientation Restraint] mtr1b_human F257A  [Orientation Restraint] mtr1b_human F257W  [Orientation Restraint]
mtr1b_human W264A  [Orientation Restraint] mtr1b_human W264S  [Orientation Restraint] mtr1b_human G271T  [Orientation Restraint]
mtr1b_human L272A  [Orientation Restraint] mtr1b_human S293A  [Orientation Restraint] npy1r_rat L34E
npy1r_rat L34R npy1r_rat P35H npy1r_rat D103A
npy1r_rat D193A npy1r_rat D199A npy1r_rat D286A


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