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GPCR-RD is a database for experimental restaints of GPCRs. Although no solved X-ray or NMR structure is available for most GPCR sequences, numerous experiments have been performed on GPCRs to identify the critical residues and motifs. Experimental restraints were systematically collected from the literature using an automated text mining algorithm combined with manual validation, with the purpose of assisting GPCR 3-D structure modeling and function annotation. The GPCR-RD data are useful for GPCR 3D structure modeling, such as the GPCR-I-TASSER algorithm. The flow chart below summarizes the procedure for the extraction of experimental data and spatial restraints from literature and other resources.

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11002 entries in GPCR-RD.
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GPCR-RD: GPCR experimental restaint database
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Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data Swiss-Prot ID Experimental Data
npy1r_rat D193A npy1r_rat D199A npy1r_rat D286A
npy2r_human L227Q  [Orientation Restraint] ntr1_rat V65A ntr1_rat D139A
ntr1_rat D139G ntr1_rat R143K ntr1_rat R143M
ntr1_rat R143Q ntr1_rat Y145A ntr1_rat Y146A
ntr1_rat F147A ntr1_rat Y154A ntr1_rat T156A
ntr1_rat M208A ntr1_rat K235A ntr1_rat K235Q
ntr1_rat K235R ntr1_rat V236A ntr1_rat R327E
ntr1_rat R327M ntr1_rat R328M ntr1_rat F331A
ntr1_rat F331Y ntr1_rat Y333A ntr1_rat W339A
o5ar1_human V114L  [Orientation Restraint] or6f1_human C123R or8k1_human W102R  [Orientation Restraint]
o51b4_human G70A  [Orientation Restraint] o51b4_human T125C o52a1_human A297G
o52b2_human T79C  [Orientation Restraint] o52b2_human C156T  [Orientation Restraint] ol226_rat K164A
oprd_mouse D128A oprd_mouse D128N oprd_mouse Y129A
oprd_mouse Y129F oprd_mouse S344A oprd_mouse S344D
oprd_mouse S344G oprd_mouse T352A oprd_mouse T353A
oprd_mouse T353E oprd_mouse E355Q oprd_mouse T358A
oprd_mouse T358D oprd_mouse T361A oprd_mouse T361D
oprd_mouse S363A oprd_mouse S363D oprd_mouse S363G
oprd_mouse D364N oprk_mouse R170E opsd_bovin Electron Microscopy 7 TMhelix x-y coordinates 32.36 31.87 36.29 44.02 45.84 42.47 48.30 32.68 54.93 26.76 46.38 21.52 39.76 31.31  [Electron Microscopy]
opsd_bovin V20G opsd_bovin P23H opsd_bovin T62A
opsd_bovin V63A opsd_bovin Q64A opsd_bovin H65C
opsd_bovin L72A opsd_bovin N73A opsd_bovin H100N
opsd_bovin C110 opsd_bovin C110F opsd_bovin E134
opsd_bovin E134D opsd_bovin E134Q opsd_bovin E134R
opsd_bovin R135 opsd_bovin R135A opsd_bovin R135E
opsd_bovin R135G opsd_bovin R135K opsd_bovin R135L
opsd_bovin R135Q opsd_bovin R135W opsd_bovin Y136C
opsd_bovin V137A opsd_bovin V138H opsd_bovin V139C
opsd_bovin C140 opsd_bovin C140S opsd_bovin S144A
opsd_bovin N145A opsd_bovin F146A opsd_bovin R147A
opsd_bovin R147Q opsd_bovin F148A opsd_bovin G149A


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