I-TASSER News


  • 2012/04/18: The I-TASSER server had the 1,000,000th protein modelled (Congratulations!). Click here to see the most recent statistics.
  • 2011/11/03: The I-TASSER Video was published at the JoVE: Journal of Visualized Experiments.
  • 2011/10/15: Visualization was enabled for the top 10 proteins analogous to the I-TASSER models and for the enzyme commission predictions.
  • 2011/10/09: The function homology search was extended to the entire PDB library. This helps increase the coverage and accuracy of the structure-based function of the I-TASSER server.
  • 2011/08/01: The I-TASSER server had the 20,000th user registered (Congratulations!).
  • 2011/03/28: The first version of the I-TASSER Suite (Version 1.1) was publicly released for download and installation. It is free for academic and non-profit users.
  • 2011/02/25: The first beta-version of the I-TASSER standalone package was ready for download and test.
  • 2011/02/22: A new message board was set up for the I-TASSER related Q&A discussions.
  • 2010/12/20: A new program, COFACTOR, was used for the structure-based protein function predictions on ligand-binding site, enzyme number, and gene-ontology. COFACTOR was ranked as the best method for function prediction in the CASP9 experiment (Congratulations!).
  • 2010/12/19: A new Java-base viewer, Jmol, was used to display predicted models and ligand-binding sites.
  • 2010/11/18: Solvent accessibility predictions were shown in the modeling result page.
  • 2010/07/20: A new option was added to allow users exclude specific proteins from the I-TASSER template library.
  • 2010/01/12: The I-TASSER server was moved from the University of Kansas to the University of Michigan Medical School. The new supercomputer cluster at UM provides help in significant speeding up the I-TASSER modeling procedure.
  • 2009/11/15: Fragment Guided Molecular Dynamic simulations (FG-MD) were implemented on I-TASSER models for steric clashes removal and local structure refinement.
  • 2009/10/17: A timer was added to the Queue page to allow users track the implementation time of their targets. A number of other changes were made in the Queue page for improving the efficiency of retrieving I-TASSER output data.
  • 2009/10/15: A new interface Search was added to allow users to search targets and predictions through the I-TASSER database.
  • 2009/07/20: Added features to allow users to assign external restraints to guide the I-TASSER structural modeling. The user-specified information includes:
    • Residue-residue contact/distance information
    • Specific template structures and alignments
    More details can be found at How to Add Restraints to I-TASSER Modeling.
  • 2009/03/16: Structure-based function predictions were developed based on the global and local match of the predicted 3D models with the known homolog and analog proteins. The function predictions include ligand binding site, enzyme commission, and gene ontology.
  • 2009/01/10: Two new predictions were added in the output page:
    • Initial threading templates identified by LOMETS.
    • Structural analogs of the I-TASSER models in the PDB library identified by TM-align.
 


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