QUARK is a computer algorithm for ab initio protein
folding and protein structure prediction, which aims to
construct the correct protein 3D model from amino acid
QUARK models are built from small fragments (1-20 residues long) by replica-exchange
Monte Carlo simulation under the guide of an atomic-level knowledge-based force field.
QUARK was ranked as the No 1 server in
Free-modeling (FM) in
Since no global template information is used in QUARK simulation,
the server is suitable for proteins which are considered without homologous templates.