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STRUM is a method for predicting the fold stability change (ΔΔG) of protein molecules upon single-point nsSNP mutations. STRUM adopts a gradient boosting regression approch to train the Gibbs free-energy changes on a variety of features at different levels of sequence and structure properties. The unique characteristics of STRUM is the combination of sequence profiles with low-resolution structure models from protein structure prediction, which helps enhance the robustness and accuracy of the method and make it applicable to various protein seqences, including those without experimental structures (>> more about STRUM ...).

[Download STRUM Package] [Benchmark] [Sequences] [Example]
Please copy and paste your data below (either [10,1500] residues sequence in FASTA format or experimental structure in PDB format is acceptable)
Click for an example FASTA input    Click for an example PDB input

Or upload the sequence/stucture file:


        Read more explanation on how to use Mode I

        Read more explanation on how to use Mode II

Email: (Mandatory, where results will be sent to. Only academic emails will be accepted.)

ID: (Optional, your given name to this protein)


References:

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