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TM-align is a highly optimized algorithm for protein structure comparison and alignment. For two protein structures of unknown equivalence, TM-align first generates the residue-to-residue alignment based on structural similarity using dynamic programming iterations. An optimal superposition of the two structures, as well as the TM-score value which scales the structural similarity, will be finally returned. The TM-score value lies in (0,1]. In general, a TM-score < 0.2 indicates that there is no similarity between two structures; a TM-score > 0.5 means the structures share the same SCOP/CATH fold.


TM-align on-line (view an example of output)

Note: This server is only for pair-wise structure comparison. If you want to match one protein structure with all proteins in the PDB library, you can do it in COFACTOR Server.


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TM-align other information

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