Home Research Services Publications People Teaching Job Opening News Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER BindProf ResQ IonCom STRUM

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot I-TASSER-MR

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW HPSF CASP7 CASP8 CASP9 CASP10 CASP11

TM-score is a metric for measuring the structural similarity of two protein models. It is designed to solve two major problems in the traditional metrics such as root-mean-square deviation (RMSD): (1) TM-score measures the global fold similarity and is less sensitive to the local structural variations; (2) magnitude of TM-score for random structure pairs is length-independent. TM-score has the value in (0,1], where 1 indicates a perfect match between two structures. Following strict statistics of structures in the PDB, scores below 0.17 corresponds to randomly chosen unrelated proteins whereas with a score higher than 0.5 assume generally the same fold in SCOP/CATH.

News: TM-score can now work for comparing complex structures (by "TMscore -c complex1.pdb complex2.pdb").


TM-score on-line (view an example of output)


TM-score download


TM-score other information

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218