> Dear Zhanglab,
> I just received the COTH results for my two protein of interest. Some
> structures are quite predictive but unfortunatenly does not exactly
> correspond with our experimental data.
>
> By co-immunoprecipitation, we have mapped the interaction domains
> comprising the R1 domain of AnxA2 (aa31-108) and the PCSK9-Cterminal
> domain (aa452-692).
>
> Therefore, is it possible to direct COTH protein-protein interaction
> using the known PDB structures of those two protieins (AnxA2; PDB#2HYW,
> aa31-108 and PCSK9; PDB#2P4E, aa452-692)
>
> Thanks again for your precious help and excellent work,
> Sincerely,
> Steve