The sequences were divided into three categories: Easy, Medium and Hard targets, based on the consensus confidence score of the meta-threading LOMETS program, which consists of 9 protein threading programs (dPPAS, MUSTER, HHpred-I,HHpred-II, PPAS, PROSPECT, SAM, SPARKS and SP3). An Easy target is defined if at least one strong template hit can be detected for the target by each program with the Z-score higher than the confidence cutoff; a Hard target is defined if none of the threading programs has a strong template hit; otherwise, it is a Medium target. In total, the 538 proteins are selected to include a balanced category distribution with 137 Easy, 177 Medium and 224 Hard targets. All proteins and their types are listed as below. # Protein Type ----------------------- 1 1ah7A easy 2 1cc8A easy 3 1cy5A easy 4 1e58A easy 5 1elkA easy 6 1gpqA easy 7 1gsoA easy 8 1gy7A easy 9 1i71A easy 10 1jovA easy 11 1k3xA easy 12 1k7jA easy 13 1kjqA easy 14 1kkoA easy 15 1lqvA easy 16 1m22A easy 17 1m40A easy 18 1m4lA easy 19 1mj4A easy 20 1mtpB easy 21 1n62B easy 22 1nxmA easy 23 1o26A easy 24 1o4yA easy 25 1o7iA easy 26 1o97D easy 27 1odmA easy 28 1of8A easy 29 1ou8A easy 30 1p6oA easy 31 1pp0A easy 32 1qtwA easy 33 1qw9A easy 34 1qwyA easy 35 1r9lA easy 36 1sz7A easy 37 1t3yA easy 38 1u8vA easy 39 1us0A easy 40 1v2bA easy 41 1v7zA easy 42 1vefA easy 43 1vkeA easy 44 1vl7A easy 45 1vrmA easy 46 1vyrA easy 47 1w0hA easy 48 1w0nA easy 49 1w4sA easy 50 1wvfA easy 51 1wwiA easy 52 1x6iA easy 53 1x9iA easy 54 1xmtA easy 55 1yd0A easy 56 1yfqA easy 57 2asbA easy 58 2bfdB easy 59 2bhuA easy 60 2bkxA easy 61 2bryA easy 62 2bzvA easy 63 2cb8A easy 64 2cxnA easy 65 2cxyA easy 66 2cygA easy 67 2cyjA easy 68 2d5wA easy 69 2dkjA easy 70 2e6fA easy 71 2eiyA easy 72 2erfA easy 73 2et1A easy 74 2ex2A easy 75 2f46A easy 76 2f60K easy 77 2fbaA easy 78 2fctA easy 79 2fozA easy 80 2fwhA easy 81 2gkeA easy 82 2h5cA easy 83 2i53A easy 84 2iqyA easy 85 2jcbA easy 86 2lisA easy 87 2pvbA easy 88 2wlvA easy 89 3aapA easy 90 3awuA easy 91 3feaA easy 92 1aopA easy 93 1arbA easy 94 1e5kA easy 95 1edgA easy 96 1ekqA easy 97 1evlA easy 98 1gp0A easy 99 1h97A easy 100 1hyoA easy 101 1i4uA easy 102 1idpA easy 103 1j77A easy 104 1jhjA easy 105 1k92A easy 106 1kngA easy 107 1kwfA easy 108 1lkkA easy 109 1nuyA easy 110 1nzjA easy 111 1q6oA easy 112 1q7eA easy 113 1r5lA easy 114 1s9rA easy 115 1sg4A easy 116 1tp6A easy 117 1tu9A easy 118 1tuaA easy 119 1uteA easy 120 1v05A easy 121 1v0wA easy 122 1vlyA easy 123 1w6sA easy 124 1xbiA easy 125 1xodA easy 126 2a6zA easy 127 2c71A easy 128 2ci1A easy 129 2ddrA easy 130 2dt8A easy 131 2dtjA easy 132 2gqtA easy 133 2hbtA easy 134 2j8bA easy 135 2jcqA easy 136 3pojA easy 137 3zquA easy 138 1a62A hard 139 1ahoA medm 140 1b8zA medm 141 1bgfA hard 142 1bx7A medm 143 1c1kA hard 144 1c4qA hard 145 1c5eA hard 146 1ccwB medm 147 1d4oA medm 148 1df4A medm 149 1dp7P medm 150 1e2wA medm 151 1eaqA hard 152 1egwA hard 153 1et1A medm 154 1ezgA medm 155 1f1eA medm 156 1f46A hard 157 1f8eA medm 158 1fiuA hard 159 1fo8A medm 160 1ft5A medm 161 1g2rA hard 162 1g4yB hard 163 1g6uA medm 164 1g6xA medm 165 1g8qA medm 166 1gk7A medm 167 1gkmA medm 168 1gppA medm 169 1gu2A medm 170 1gutA medm 171 1gvpA medm 172 1gwmA hard 173 1h2cA hard 174 1hbnC hard 175 1hfeS hard 176 1hq1A medm 177 1i27A hard 178 1ifrA hard 179 1irqA medm 180 1iuqA medm 181 1ix9A hard 182 1j2jB medm 183 1j98A hard 184 1jk3A medm 185 1jniA medm 186 1jo0A hard 187 1jy2N medm 188 1jy2O medm 189 1jy2P medm 190 1k4iA medm 191 1k4nA hard 192 1kafA hard 193 1kmtA medm 194 1kqrA hard 195 1lmiA medm 196 1lniA medm 197 1ltzA hard 198 1lwbA hard 199 1lyqA medm 200 1m1qA medm 201 1m55A hard 202 1m9zA medm 203 1mc2A medm 204 1mg7A medm 205 1mn8A medm 206 1mnnA hard 207 1n0qA medm 208 1n13A medm 209 1n13B medm 210 1n7sA medm 211 1n7sB medm 212 1n8vA hard 213 1ng6A medm 214 1nkdA hard 215 1nkgA medm 216 1nlnA medm 217 1nlqA medm 218 1nnxA medm 219 1nqjA medm 220 1nthA medm 221 1nwaA hard 222 1nycA medm 223 1o82A medm 224 1o8bA medm 225 1ok0A hard 226 1oqjA medm 227 1q7lB medm 228 1qlwA medm 229 1qv9A hard 230 1qw2A hard 231 1qwgA medm 232 1r7jA medm 233 1rfyA medm 234 1rkiA medm 235 1rocA hard 236 1rp0A medm 237 1rv9A hard 238 1rylA hard 239 1ryqA medm 240 1s1dA medm 241 1sauA hard 242 1sfsA medm 243 1svfA medm 244 1svfB medm 245 1sx5A hard 246 1szhA hard 247 1t61A hard 248 1t6fA medm 249 1t6uA hard 250 1t92A hard 251 1tukA medm 252 1tzpA hard 253 1u07A medm 254 1u2hA medm 255 1u84A hard 256 1ufyA hard 257 1ug6A medm 258 1ugiA hard 259 1ukfA hard 260 1uoyA hard 261 1uwkA medm 262 1uz3A hard 263 1v8hA medm 264 1vccA medm 265 1ve4A medm 266 1vjuA hard 267 1vmhA hard 268 1vp8A medm 269 1vqsA medm 270 1vr7A medm 271 1vtz0 hard 272 1vyiA hard 273 1w53A hard 274 1w5qA hard 275 1wc2A medm 276 1wddS hard 277 1whiA hard 278 1whzA medm 279 1wn2A medm 280 1wnaA hard 281 1wpaA medm 282 1wpuA hard 283 1wt6A hard 284 1wu9A hard 285 1wuiL medm 286 1wvqA hard 287 1x0tA hard 288 1xg0A hard 289 1xyiA hard 290 1y43B medm 291 1y9lA hard 292 1yb3A hard 293 1ybkA hard 294 1yc5A medm 295 1ye8A medm 296 1ylxA hard 297 1yn3A medm 298 1ypyA hard 299 1z0jB medm 300 1z3eB medm 301 1z3xA medm 302 1z67A hard 303 1zhxA hard 304 1zk5A hard 305 1zkeA hard 306 1zv1A hard 307 1zvaA hard 308 256bA medm 309 2a26A medm 310 2aibA hard 311 2akzA medm 312 2apjA medm 313 2arcA medm 314 2au7A hard 315 2aydA hard 316 2b0aA hard 317 2b3gA medm 318 2b4hA hard 319 2b97A medm 320 2b9dA medm 321 2bcmA hard 322 2bdrA hard 323 2bemA hard 324 2bf9A medm 325 2bl8A hard 326 2brjA hard 327 2bt9A hard 328 2bu3A medm 329 2bz1A hard 330 2cc6A medm 331 2ccqA hard 332 2cg7A medm 333 2chhA hard 334 2ciuA hard 335 2ciwA hard 336 2ckkA medm 337 2cmpA medm 338 2covD hard 339 2cpgA medm 340 2cs7A hard 341 2cveA medm 342 2cwsA medm 343 2cxaA hard 344 2czsA hard 345 2d68A hard 346 2dlbA hard 347 2dpfA medm 348 2dqaA medm 349 2ds5A medm 350 2dvmA medm 351 2e7zA medm 352 2ehpA medm 353 2endA hard 354 2engA medm 355 2ev1A medm 356 2f22A medm 357 2f9hA hard 358 2fcjA medm 359 2fclA medm 360 2fcoA medm 361 2fcwA hard 362 2fhzA hard 363 2fhzB hard 364 2fkkA medm 365 2fmaA medm 366 2fomB hard 367 2fsqA medm 368 2fufA hard 369 2fyqA medm 370 2g7oA hard 371 2gkpA hard 372 2gomA hard 373 2gpiA medm 374 2grrB hard 375 2h8eA hard 376 2hbaA hard 377 2hewF hard 378 2hlyA hard 379 2hw2A hard 380 2ia1A hard 381 2ia7A medm 382 2ip6A medm 383 2ixmA hard 384 2j5yA hard 385 2jekA hard 386 2mcmA hard 387 2nmlA hard 388 2nuhA medm 389 2o9uX medm 390 2ofcA hard 391 2ofkA hard 392 2ohwA medm 393 2okfA hard 394 2ooaA medm 395 2opcA medm 396 2p4fA hard 397 2p6wA hard 398 2p8gA hard 399 2p8iA hard 400 2phnA hard 401 2pthA hard 402 2pu3A hard 403 2pyqA hard 404 2q3tA hard 405 2q4nA hard 406 2qf4A hard 407 2qfaB hard 408 2qguA hard 409 2qskA medm 410 2qudA hard 411 2ra9A hard 412 2rbdA hard 413 2rh2A medm 414 2rklA medm 415 2v3iA hard 416 2v7fA hard 417 2vb1A hard 418 2vbkA medm 419 2vh3A hard 420 2vlqA hard 421 2vlqB hard 422 2vqpA hard 423 2w8xA medm 424 2wh7A hard 425 2wnpF hard 426 2wq4A hard 427 2wtpA hard 428 2wwxB hard 429 2wzoA hard 430 2x3mA hard 431 2xetA hard 432 2xqoA hard 433 2xqqA hard 434 2xrhA hard 435 2xttA medm 436 2xz2A medm 437 2y5pA hard 438 2y71A hard 439 2y9fA medm 440 2z6oA medm 441 2zk9X hard 442 3a16A medm 443 3a57A hard 444 3a8gA hard 445 3aqjA medm 446 3b4qA hard 447 3bfoA medm 448 3bhwA hard 449 3bmzA hard 450 3bo6A hard 451 3boeA hard 452 3bonA medm 453 3brcA hard 454 3bs1A hard 455 3bxuA medm 456 3c8lA hard 457 3c9aA hard 458 3c9qA medm 459 3chbD medm 460 3chmA medm 461 3cjsA hard 462 3cxnA hard 463 3dnjA hard 464 3dsoA hard 465 3eojA hard 466 3essA hard 467 3fdeA medm 468 3filA hard 469 3fjuB hard 470 3fkeA hard 471 3fzeA hard 472 3gkjA hard 473 3gmgA hard 474 3gocA medm 475 3h87C medm 476 3hlzA hard 477 3hynA medm 478 3ie4A hard 479 3imkA medm 480 3iohA hard 481 3iuoA hard 482 3jtzA medm 483 3k7iB hard 484 3klrA hard 485 3kxtA hard 486 3kyzA hard 487 3l9aX hard 488 3lfkA hard 489 3lgbA hard 490 3lhnA medm 491 3lzqA hard 492 3m8jA medm 493 3mabA medm 494 3maoA hard 495 3meaA medm 496 3molA hard 497 3mxnA medm 498 3n6yA hard 499 3ndhA hard 500 3nirA medm 501 3nj2A hard 502 3njnA hard 503 3no7A medm 504 3npdA medm 505 3nr5A hard 506 3nrfA medm 507 3nufA medm 508 3nzlA hard 509 3o79A medm 510 3oblA hard 511 3ofgA hard 512 3omdA hard 513 3on9A hard 514 3ov5A medm 515 3ov9A hard 516 3p4hA hard 517 3pesA hard 518 3plwA hard 519 3pp5A hard 520 3pviA hard 521 3q1iA hard 522 3q7cA hard 523 3qc7A hard 524 3qu3A medm 525 3sojA medm 526 3tduC medm 527 3ts3A hard 528 3tu8A hard 529 3u6gA medm 530 3u7zA medm 531 3zr8X hard 532 3zuzA hard 533 3zyhA hard 534 3zzpA medm 535 3zzsA medm 536 4a3pA hard 537 4ubpA hard 538 4ubpB hard