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SPRING is a template-base algorithm for protein-protein structure prediction. It first threads one chain of the protein complex through the PDB library with the binding parters retrieved from the original oligomer entries. The complex models associated with another chain is deduced from a pre-calculated look-up table, with the best orientation selected by the SPRING-score which is a combination of threading Z-score, interface contacts, and TM-align match between monomer-to-dimer templates.

The output of the SPRING server include (An example of the SPRING output):

Cut and paste your first sequence in FASTA format here:

Or upload the sequence from your local computer:

Cut and paste your second sequence in FASTA format here:

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)




Reference:
Aysam Guerler, Brandon Govindarajoo, Yang Zhang. Mapping Monomeric Threading to Protein-Protein Structure Prediction. Journal of Chemical Information and Modeling, 53, 717-725 (2013) (Download PDF

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