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BioLiP news

BioLiP update news


  • 2017-12-08: BioLiP was updated with 398,783 entries.
  • 2017-12-01: BioLiP was updated with 398,059 entries.
  • 2017-11-24: BioLiP was updated with 397,531 entries.
  • 2017-11-17: BioLiP was updated with 397,097 entries.
  • 2017-11-03: BioLiP was updated with 396,445 entries.
  • 2017-10-27: BioLiP was updated with 395,558 entries.
  • 2017-10-20: BioLiP was updated with 395,020 entries.
  • 2017-10-13: BioLiP was updated with 394,481 entries.
  • 2017-10-06: BioLiP was updated with 393,934 entries.
  • 2017-09-29: BioLiP was updated with 393,452 entries.
  • 2017-09-22: BioLiP was updated with 392,815 entries.
  • 2017-09-15: BioLiP was updated with 391,250 entries.
  • 2017-09-08: BioLiP was updated with 390,566 entries.
  • 2017-09-01: BioLiP was updated with 390,307 entries.
  • 2017-08-25: BioLiP was updated with 389,413 entries.
  • 2017-08-18: BioLiP was updated with 388,938 entries.
  • 2017-08-11: BioLiP was updated with 387,679 entries.
  • 2017-08-04: BioLiP was updated with 386,796 entries.
  • 2017-07-28: BioLiP was updated with 386,031 entries.
  • 2017-07-21: BioLiP was updated with 385,400 entries.
  • 2017-07-14: BioLiP was updated with 384,687 entries.
  • 2017-07-07: BioLiP was updated with 383,790 entries.
  • 2017-06-30: BioLiP was updated with 383,086 entries.
  • 2017-06-23: BioLiP was updated with 382,332 entries.
  • 2017-06-16: BioLiP was updated with 381,208 entries.
  • 2017-06-09: BioLiP was updated with 380,637 entries.
  • 2017-06-02: BioLiP was updated with 380,215 entries.
  • 2017-05-26: BioLiP was updated with 379,637 entries.
  • 2017-05-19: BioLiP was updated with 378,881 entries.
  • 2017-05-12: BioLiP was updated with 378,449 entries.
  • 2017-05-05: BioLiP was updated with 377,843 entries.
  • 2017-04-28: BioLiP was updated with 377,031 entries.
  • 2017-04-21: BioLiP was updated with 376,485 entries.
  • 2017-04-14: BioLiP was updated with 375,917 entries.
  • 2017-04-07: BioLiP was updated with 375,270 entries.
  • 2017-03-31: BioLiP was updated with 374,810 entries.
  • 2017-03-24: BioLiP was updated with 374,328 entries.
  • 2017-03-17: BioLiP was updated with 372,860 entries.
  • 2017-03-10: BioLiP was updated with 371,501 entries.
  • 2017-03-03: BioLiP was updated with 370,917 entries.
  • 2017-02-24: BioLiP was updated with 370,422 entries.
  • 2017-02-17: BioLiP was updated with 369,770 entries.
  • 2017-02-10: BioLiP was updated with 369,147 entries.
  • 2017-02-03: BioLiP was updated with 368,541 entries.
  • 2017-01-27: BioLiP was updated with 368,127 entries.
  • 2017-01-20: BioLiP was updated with 367,611 entries.
  • 2017-01-13: BioLiP was updated with 366,613 entries.
  • 2017-01-06: BioLiP was updated with 365,852 entries.
  • 2016-12-30: BioLiP was updated with 365,609 entries.
  • 2016-12-23: BioLiP was updated with 365,239 entries.
  • 2016-12-16: BioLiP was updated with 364,570 entries.
  • 2016-12-09: BioLiP was updated with 364,157 entries.
  • 2016-12-02: BioLiP was updated with 363,659 entries.
  • 2016-11-25: BioLiP was updated with 363,291 entries.
  • 2016-11-18: BioLiP was updated with 362,921 entries.
  • 2016-11-11: BioLiP was updated with 362,513 entries.
  • 2016-11-04: BioLiP was updated with 361,460 entries.
  • 2016-10-28: BioLiP was updated with 360,916 entries.
  • 2016-10-21: BioLiP was updated with 360,152 entries.
  • 2016-10-14: BioLiP was updated with 359,540 entries.
  • 2016-10-07: BioLiP was updated with 359,132 entries.
  • 2016-09-30: BioLiP was updated with 358,378 entries.
  • 2016-09-23: BioLiP was updated with 357,782 entries.
  • 2016-09-16: BioLiP was updated with 357,214 entries.
  • 2016-09-09: BioLiP was updated with 356,366 entries.
  • 2016-09-02: BioLiP was updated with 355,810 entries.
  • 2016-08-26: BioLiP was updated with 355,291 entries.
  • 2016-08-19: BioLiP was updated with 354,957 entries.
  • 2016-08-12: BioLiP was updated with 354,383 entries.
  • 2016-08-05: BioLiP was updated with 353,550 entries.
  • 2016-07-29: BioLiP was updated with 352,944 entries.
  • 2016-07-22: BioLiP was updated with 352,233 entries.
  • 2016-07-15: BioLiP was updated with 351,801 entries.
  • 2016-07-08: BioLiP was updated with 351,508 entries.
  • 2016-07-01: BioLiP was updated with 350,864 entries.
  • 2016-06-24: BioLiP was updated with 349,997 entries.
  • 2016-06-17: BioLiP was updated with 349,385 entries.
  • 2016-06-10: BioLiP was updated with 348,851 entries.
  • 2016-06-03: BioLiP was updated with 348,406 entries.
  • 2016-05-27: BioLiP was updated with 347,662 entries.
  • 2016-05-20: BioLiP was updated with 347,074 entries.
  • 2016-05-13: BioLiP was updated with 346,174 entries.
  • 2016-05-06: BioLiP was updated with 345,753 entries.
  • 2016-04-29: BioLiP was updated with 344,248 entries.
  • 2016-04-22: BioLiP was updated with 343,744 entries.
  • 2016-04-15: BioLiP was updated with 343,223 entries.
  • 2016-04-08: BioLiP was updated with 342,695 entries.
  • 2016-04-01: BioLiP was updated with 342,088 entries.
  • 2016-03-25: BioLiP was updated with 341,176 entries.
  • 2016-03-18: BioLiP was updated with 340,165 entries.
  • 2016-03-11: BioLiP was updated with 339,764 entries.
  • 2016-03-04: BioLiP was updated with 338,840 entries.
  • 2016-02-26: BioLiP was updated with 337,885 entries.
  • 2016-02-19: BioLiP was updated with 337,392 entries.
  • 2016-02-12: BioLiP was updated with 336,865 entries.
  • 2016-02-05: BioLiP was updated with 336,318 entries.
  • 2016-01-29: BioLiP was updated with 335,748 entries.
  • 2016-01-22: BioLiP was updated with 334,990 entries.
  • 2016-01-15: BioLiP was updated with 334,124 entries.
  • 2016-01-08: BioLiP was updated with 333,208 entries.
  • 2016-01-01: BioLiP was updated with 333,129 entries.
  • 2015-12-25: BioLiP was updated with 332,818 entries.
  • 2015-12-18: BioLiP was updated with 332,119 entries.
  • 2015-12-11: BioLiP was updated with 331,591 entries.
  • 2015-12-04: BioLiP was updated with 331,211 entries.
  • 2015-11-27: BioLiP was updated with 331,004 entries.
  • 2015-11-20: BioLiP was updated with 330,448 entries.
  • 2015-11-13: BioLiP was updated with 330,096 entries.
  • 2015-11-06: BioLiP was updated with 329,582 entries.
  • 2015-10-30: BioLiP was updated with 328,934 entries.
  • 2015-10-23: BioLiP was updated with 328,062 entries.
  • 2015-10-16: BioLiP was updated with 327,648 entries.
  • 2015-10-09: BioLiP was updated with 326,999 entries.
  • 2015-10-02: BioLiP was updated with 326,565 entries.
  • 2015-09-25: BioLiP was updated with 326,035 entries.
  • 2015-09-18: BioLiP was updated with 325,021 entries.
  • 2015-09-11: BioLiP was updated with 324,626 entries.
  • 2015-09-04: BioLiP was updated with 324,122 entries.
  • 2015-08-28: BioLiP was updated with 323,418 entries.
  • 2015-08-21: BioLiP was updated with 322,708 entries.
  • 2015-08-14: BioLiP was updated with 322,143 entries.
  • 2015-08-07: BioLiP was updated with 321,562 entries.
  • 2015-07-31: BioLiP was updated with 320,873 entries.
  • 2015-07-24: BioLiP was updated with 320,395 entries.
  • 2015-07-17: BioLiP was updated with 319,868 entries.
  • 2015-07-10: BioLiP was updated with 319,085 entries.
  • 2015-07-03: BioLiP was updated with 318,747 entries.
  • 2015-06-26: BioLiP was updated with 317,989 entries.
  • 2015-06-19: BioLiP was updated with 317,463 entries.
  • 2015-06-12: BioLiP was updated with 316,531 entries.
  • 2015-06-05: BioLiP was updated with 315,670 entries.
  • 2015-05-29: BioLiP was updated with 315,241 entries.
  • 2015-05-22: BioLiP was updated with 314,856 entries.
  • 2015-05-15: BioLiP was updated with 314,392 entries.
  • 2015-05-08: BioLiP was updated with 313,991 entries.
  • 2015-05-01: BioLiP was updated with 313,411 entries.
  • 2015-04-24: BioLiP was updated with 313,023 entries.
  • 2015-04-17: BioLiP was updated with 312,532 entries.
  • 2015-04-10: BioLiP was updated with 312,155 entries.
  • 2015-04-03: BioLiP was updated with 311,725 entries.
  • 2015-03-27: BioLiP was updated with 311,356 entries.
  • 2015-03-20: BioLiP was updated with 310,616 entries.
  • 2015-03-13: BioLiP was updated with 310,130 entries.
  • 2015-03-06: BioLiP was updated with 309,436 entries.
  • 2015-02-27: BioLiP was updated with 308,776 entries.
  • 2015-02-20: BioLiP was updated with 308,391 entries.
  • 2015-02-13: BioLiP was updated with 307,822 entries.
  • 2015-02-06: BioLiP was updated with 306,707 entries.
  • 2015-01-30: BioLiP was updated with 305,121 entries.
  • 2015-01-23: BioLiP was updated with 304,683 entries.
  • 2015-01-16: BioLiP was updated with 304,050 entries.
  • 2015-01-09: BioLiP was updated with 303,348 entries.
  • 2015-01-02: BioLiP was updated with 303,247 entries.
  • 2014-12-26: BioLiP was updated with 302,893 entries.
  • 2014-12-19: BioLiP was updated with 302,317 entries.
  • 2014-12-12: BioLiP was updated with 301,728 entries.
  • 2014-12-05: BioLiP was updated with 301,192 entries.
  • 2014-11-28: BioLiP was updated with 300,430 entries.
  • 2014-11-21: BioLiP was updated with 299,877 entries.
  • 2014-11-14: BioLiP was updated with 299,390 entries.
  • 2014-11-07: BioLiP was updated with 299,005 entries.
  • 2014-10-31: BioLiP was updated with 298,556 entries.
  • 2014-10-24: BioLiP was updated with 297,921 entries.
  • 2014-10-17: BioLiP was updated with 295,553 entries.
  • 2014-10-10: BioLiP was updated with 293,689 entries.
  • 2014-10-03: BioLiP was updated with 293,075 entries.
  • 2014-09-26: BioLiP was updated with 292,016 entries.
  • 2014-09-19: BioLiP was updated with 291,446 entries.
  • 2014-09-12: BioLiP was updated with 290,962 entries.
  • 2014-09-10: The ocurence frequency of all ligands in BioLiP was provided on the ligand information page.
  • 2014-09-10: A Perl script (download_all_sets.pl) was provided for automatic download of all the weekly updated subsets.
  • 2014-09-05: BioLiP was updated with 290,340 entries.
  • 2014-08-29: BioLiP was updated with 289,726 entries.
  • 2014-08-22: BioLiP was updated with 289,183 entries.
  • 2014-08-15: BioLiP was updated with 287,808 entries.
  • 2014-08-08: BioLiP was updated with 286,977 entries.
  • 2014-08-01: BioLiP was updated with 285,404 entries.
  • 2014-07-25: BioLiP was updated with 284,044 entries.
  • 2014-07-18: BioLiP was updated with 283,521 entries.
  • 2014-07-11: BioLiP was updated with 282,354 entries.
  • 2014-07-04: BioLiP was updated with 281,459 entries.
  • 2014-06-27: BioLiP was updated with 280,813 entries.
  • 2014-06-20: BioLiP was updated with 280,296 entries.
  • 2014-06-13: BioLiP was updated with 279,474 entries.
  • 2014-06-06: BioLiP was updated with 278,970 entries.
  • 2014-05-30: BioLiP was updated with 278,455 entries.
  • 2014-05-23: BioLiP was updated with 277,782 entries.
  • 2014-05-16: BioLiP was updated with 277,235 entries.
  • 2014-05-09: BioLiP was updated with 276,626 entries.
  • 2014-05-02: BioLiP was updated with 276,074 entries.
  • 2014-04-25: BioLiP was updated with 275,646 entries.
  • 2014-04-18: BioLiP was updated with 275,162 entries.
  • 2014-04-11: BioLiP was updated with 274,651 entries.
  • 2014-04-04: BioLiP was updated with 273,568 entries.
  • 2014-03-28: BioLiP was updated with 272,557 entries.
  • 2014-03-21: BioLiP was updated with 271,910 entries.
  • 2014-03-14: BioLiP was updated with 271,375 entries.
  • 2014-03-07: BioLiP was updated with 270,981 entries.
  • 2014-02-28: BioLiP was updated with 270,316 entries.
  • 2014-02-21: BioLiP was updated with 269,908 entries.
  • 2014-02-14: BioLiP was updated with 269,450 entries.
  • 2014-02-07: BioLiP was updated with 268,788 entries.
  • 2014-01-31: BioLiP was updated with 267,713 entries.
  • 2014-01-24: BioLiP was updated with 267,274 entries.
  • 2014-01-17: BioLiP was updated with 266,774 entries.
  • 2014-01-10: BioLiP was updated with 266,318 entries.
  • 2014-01-03: BioLiP was updated with 266,002 entries.
  • 2013-12-27: BioLiP was updated with 265,829 entries.
  • 2013-12-20: BioLiP was updated with 265,285 entries.
  • 2013-12-13: BioLiP was updated with 264,561 entries.
  • 2013-12-06: BioLiP was updated with 263,760 entries.
  • 2013-11-29: BioLiP was updated with 263,196 entries.
  • 2013-11-22: BioLiP was updated with 262,649 entries.
  • 2013-11-15: BioLiP was updated with 262,248 entries.
  • 2013-11-08: BioLiP was updated with 260,849 entries.
  • 2013-11-01: BioLiP was updated with 260,129 entries.
  • 2013-10-25: BioLiP was updated with 259,245 entries.
  • 2013-10-18: BioLiP was updated with 258,656 entries.
  • 2013-10-11: BioLiP was updated with 258,317 entries.
  • 2013-10-04: BioLiP was updated with 257,701 entries.
  • 2013-09-27: BioLiP was updated with 257,194 entries.
  • 2013-09-20: BioLiP was updated with 256,910 entries.
  • 2013-09-13: BioLiP was updated with 256,315 entries.
  • 2013-09-06: BioLiP was updated with 255,963 entries.
  • 2013-08-30: BioLiP was updated with 255,496 entries.
  • 2013-08-23: BioLiP was updated with 254,957 entries.
  • 2013-08-19: A link was added at the search and browse pages to allow users to export searching results in CSV format.
  • 2013-08-16: BioLiP was updated with 254,447 entries.
  • 2013-08-09: BioLiP was updated with 253,952 entries.
  • 2013-08-02: BioLiP was updated with 253,216 entries.
  • 2013-07-26: BioLiP was updated with 252,564 entries.
  • 2013-07-19: BioLiP was updated with 251,893 entries.
  • 2013-07-12: BioLiP was updated with 250,703 entries.
  • 2013-07-05: BioLiP was updated with 250,241 entries.
  • 2013-06-28: BioLiP was updated with 249,116 entries.
  • 2013-06-21: BioLiP was updated with 248,580 entries.
  • 2013-06-14: BioLiP was updated with 248,096 entries.
  • 2013-06-07: BioLiP was updated with 247,557 entries.
  • 2013-05-31: BioLiP was updated with 246,890 entries.
  • 2013-05-24: BioLiP was updated with 246,417 entries.
  • 2013-05-17: BioLiP was updated with 245,911 entries.
  • 2013-05-10: BioLiP was updated with 245,395 entries.
  • 2013-05-03: BioLiP was updated with 244,820 entries.
  • 2013-04-26: BioLiP was updated with 243,943 entries.
  • 2013-04-19: BioLiP was updated with 243,042 entries.
  • 2013-04-12: BioLiP was updated with 242,582 entries.
  • 2013-04-05: BioLiP was updated with 241,909 entries.
  • 2013-03-29: BioLiP was updated with 241,204 entries.
  • 2013-03-22: BioLiP was updated with 240,565 entries.
  • 2013-03-15: BioLiP was rebuilt with the following changes: (1) All DNA/RNA-protein interactions from PDB were added, which should be useful for studying Nucleic Acids-protein interactions. In previous versions, only small DNA/RNA ligands were considered. (2) The k-mer ligand "UUU" was divided into component ligands and removed from the database.
  • 2013-03-08: BioLiP was updated with 217,294 entries.
  • 2013-03-01: BioLiP was updated with 216,666 entries.
  • 2013-02-22: BioLiP was updated with 216,087 entries.
  • 2013-02-15: BioLiP was updated with 215,157 entries.
  • 2013-02-08: BioLiP was updated with 214,612 entries.
  • 2013-02-01: BioLiP was updated with 214,197 entries.
  • 2013-01-25: BioLiP was updated with 213,766 entries.
  • 2013-01-18: BioLiP was updated with 213,173 entries.
  • 2013-01-11: BioLiP was updated with 212,628 entries.
  • 2013-01-04: BioLiP was updated with 212,266 entries.
  • 2012-12-28: BioLiP was updated with 212,036 entries.
  • 2012-12-21: BioLiP was updated with 211,687 entries.
  • 2012-12-14: BioLiP was updated with 211,382 entries. 102 ligands were added to the artifact ligand list, which helped us reduce about 1000 false positive entries.
  • 2012-12-07: BioLiP was updated with 211,819 entries. 642 false postive entries for the ligands RG1 and IMD were manually removed.
  • 2012-11-30: BioLiP was updated with 212,148 entries. The COACH algorithm was redesigned and is available at here.
  • 2012-11-23: BioLiP was updated with 211,852 entries.
  • 2012-11-16: BioLiP was updated with 211,040 entries. 233 false postive entries for the ligands FTT and MYR were manually removed.
  • 2012-11-09: BioLiP was updated with 210,894 entries. The number of BioLiP entries with binding affinity data was increased from 20127 to 22091 with the latest realse of the PDBbind-CN database.
  • 2012-11-02: BioLiP was updated with 210,377 entries. 108 false postive entries for the ligands TRD and UND were manually removed.
  • 2012-10-26: BioLiP was updated with 209,775 entries.
  • 2012-10-19: BioLiP was updated with 209,291 entries. BioLiP manuscript was published online in Nucleic Acids Research.
  • 2012-10-12: BioLiP was updated with 208,649 entries. 104 false postive entries for the ligands D10, D12, DD9, HP6, and R16 were manually removed.
  • 2012-10-05: BioLiP was updated with 208,366 entries. 69 false postive entries for the ligand LFA were manually removed.
  • 2012-09-28: BioLiP was updated with 208,003 entries. Some minor bugs in our script were fixed, resulting the addition of about 3000 new BioLiP entries.
  • 2012-09-25: BioLiP manuscript was accepted by Nucleic Acids Research.
  • 2012-09-21: BioLiP was updated with 204,599 entries.
  • 2012-09-14: BioLiP was updated with 204,223 entries. (1) 21 missed true positives (for the ligand CXS) were manually added in the new release. (2) The PDB's original residue numbering system was retained.
  • 2012-09-07: BioLiP was updated with 203,852 entries.
  • 2012-09-01: BioLiP was updated with 203,373 entries. (1) 18 missed true positives (for the ligand PMS) were manually added in the new release. (2) A more stringent filter was added for metal ion ligands to remove 5,393 flase positives.
  • 2012-08-25: BioLiP was updated with 208,122 entries. (1) Crystallization neighbors were excluded using the record "REMARK 350" in the PDB file. (2) Two detergent molecules (OLB, OLC) were added to the artifact list due to 232 false positives indentified. (3) Five different keywords (BioLiP ID, PDB ID, Ligand ID, UniProt ID, and Resolution) were provided for sorting searching results.
  • 2012-08-03: BioLiP was updated with 208,494 entries. (1) The resolution of the PDB structures was added into BioLiP. (2) The columns 18-20 in the PDB files of DNA/RNA were changed from "NUC" to the original PDB format. (3) 41 BioLiP entries with obsolete PDB IDs were removed.
  • 2012-07-25: BioLiP was updated with 208,184 entries.
  • 2012-07-10: BioLiP was updated with 207,628 entries. (1) Seven ligand molecules (XE, HG, F, TL, BA, LI, BR) were moved from the exclude list to the artifact list (2)Ten ligand molecules (TAU, TCA, SPD, SPM, SAR, SUC, PAM, SPH, BE7, P4G) were added to the artifact list due to 387 false positives indentified.
  • 2012-07-03: BioLiP was updated with 206,615 entries. (1) The ligand molecule chloride (CL) was moved from the exclude list to the artifact list. (2) 115 false positives (for 2PE, C8E, P6G, 12P, PG4, PE4, EDO, ETE, P4C, 1PE, PEG) caused by wrong keyword match "glycol" were manually removed.
  • 2012-06-26: BioLiP was updated with 205,732 entries.
  • 2012-06-19: The BioLiP database (with 205,373 entries) was released by Dr. Yang Zhang's research group at University of Michigan.

  • Reference:
    Jianyi Yang, Ambrish Roy and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

    yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218