Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA FASPR

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13


C-I-TASSER (Contact-guided Iterative Threading ASSEmbly Refinement) is a new method extended from I-TASSER for high-accuracy protein structure and function predictions. Starting from a query sequence, C-I-TASSER first generates inter-residue contact maps using multiple deep neural-network predictors, including NeBcon, ResPRE, and TripletRes. It then identifies structural templates from the PDB by multiple threading approach LOMETS, with full-length atomic models assembled by contact-map guided replica-exchange Monte Carlo simulations. Biological functions of the query protein are finally derived from the structure model by COFACTOR. The large-scale benchmark tests showed that C-I-TASSER generates significantly more accurate models than I-TASSER, especially for the sequences that do not have homologous templates in the PDB. Please report problems and questions at our Discussion Board.

[Check jobs] [Server statistics] [Benchmark dataset] [SARS-CoV-2 models] [Pfam Structures] [Download] [Help] [Forum]

C-I-TASSER On-line Server (View example output):
References:

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218