C-I-TASSER (Contact-guided Iterative Threading ASSEmbly Refinement) is a composite method that uses contact information to improve the accuracy of protein structure and function predictions. Starting from a sequence, C-I-TASSER first generates contact-map between all residue pairs using multiple deep neural-network predictors, including NeBcon, ResPRE, ResTriplet, and TripletRes. It then identifies structural templates from the PDB by multiple threading approach LOMETS, with full-length atomic models assembled by contact-map guided Monte Carlo simulations. Functions of the target are finally derived from the structure model by COFACTOR. C-I-TASSER (as 'Zhang-Server') was ranked as the No 1 Server for protein structure prediction in the community-wide CASP12 and CASP13 experiments. The benchmark data showed that C-I-TASSER could generate significantly more accurate models than I-TASSER, especially for the sequences that do not have homologous templates in the PDB.
From May. 10 to Jul. 30, 2020, the C-I-TASSER server will be shut down due to computing resource limit. Jobs submitted during this period will run after CASP14. We apologize for any inconvenience this may cause.
yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218