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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13


C-I-TASSER (Contact-guided Iterative Threading ASSEmbly Refinement) is a composite approach that uses contact information to enhance the accuracy of protein structure and function predictions. Starting from a sequence, C-I-TASSER first generates contact-map of all residue pairs using NeBcon, ResPRE, ResTriplet, and TripletRes. It then identifies structural templates from the PDB by multiple threading approach LOMETS, with full-length atomic models constructed by contact-map guided fragment assembly simulations. Functions of the target are derived from the structure model by COFACTOR. C-I-TASSER (as 'Zhang-Server') was ranked as the No. 1 server for protein structure prediction in the community-wide CASP12 and CASP13 experiment. The benchmark data showed that C-I-TASSER could generate significantly more accurate models than I-TASSER, especially for the sequences that do not have homologous templates in the PDB.

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