gene name common name UniProt entry (canonical isoform) COFACTOR (MF) COFACTOR (BP) COFACTOR (CC) Function description UniProt-GOA (non-IEA) UniProtGOA (IEA only) UniProt annotation score NextProt (GOLD) NextProt (SILVER) chromosome location tissue-specific protein expression tissue-specific RNA expression sequence FAM57A FAM57A FA57A_HUMAN (Q8TBR7-2) GO:0016740 (1.00) ! transferase activity; GO:0050291 (0.99) ! sphingosine N-acyltransferase activity GO:0048856 (0.59) ! anatomical structure development; GO:1901564 (0.57) ! organonitrogen compound metabolic process; GO:0006629 (0.57) ! lipid metabolic process; GO:0007420 (0.54) ! brain development; GO:0021952 (0.53) ! central nervous system projection neuron axonogenesis; GO:0001654 (0.53) ! eye development; GO:0006672 (0.46) ! ceramide metabolic process; GO:0046467 (0.42) ! membrane lipid biosynthetic process; GO:0046513 (0.41) ! ceramide biosynthetic process GO:0005887 (1.00) ! integral component of plasma membrane; GO:0005886 (1.00) ! plasma membrane; GO:0005783 (0.98) ! endoplasmic reticulum; GO:0097458 (0.37) ! neuron part; GO:0042995 (0.37) ! cell projection GO:0005886 ! plasma membrane; GO:0005515 ! protein binding GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 GO:0005515 ! protein binding 732412-742972 (17p13.3) Skin - Not Sun Exposed (Suprapubic): 100.10; Skin - Sun Exposed (Lower leg): 82.99; Cells - Transformed fibroblasts: 40.88; Esophagus - Mucosa: 31.07; Vagina: 30.35; Cells - EBV-transformed lymphocytes: 25.44; Testis: 19.01; Cervix - Ectocervix: 18.05; Pituitary: 16.76; Prostate: 16.61; Bladder: 16.54; Cervix - Endocervix: 16.34; Stomach: 15.38; Minor Salivary Gland: 15.32; Nerve - Tibial: 14.37; Brain - Cerebellum: 13.71; Brain - Cerebellar Hemisphere: 13.55; Fallopian Tube: 13.53; Uterus: 12.82; Thyroid: 12.66; MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVSSVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQNRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQRLRGDLGDFFVGCIFTAELSTPFVSLGRVLIQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSIPFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG TLCD2 TLC domain-containing protein 2 TLCD2_HUMAN (A6NGC4-1) GO:0016740 (0.86) ! transferase activity; GO:0050291 (0.76) ! sphingosine N-acyltransferase activity; GO:0005216 (0.59) ! ion channel activity; GO:0009881 (0.55) ! photoreceptor activity GO:0006643 (0.76) ! membrane lipid metabolic process; GO:0006672 (0.73) ! ceramide metabolic process; GO:0044765 (0.61) ! single-organism transport; GO:0006811 (0.60) ! ion transport; GO:0034220 (0.58) ! ion transmembrane transport; GO:0019538 (0.58) ! protein metabolic process; GO:0050896 (0.55) ! response to stimulus; GO:0006464 (0.54) ! cellular protein modification process; GO:0018298 (0.53) ! protein-chromophore linkage; GO:0007602 (0.53) ! phototransduction; GO:0048856 (0.50) ! anatomical structure development; GO:0046467 (0.48) ! membrane lipid biosynthetic process; GO:0046513 (0.46) ! ceramide biosynthetic process; GO:0015992 (0.40) ! proton transport; GO:0006644 (0.34) ! phospholipid metabolic process; GO:0008203 (0.31) ! cholesterol metabolic process; GO:0007399 (0.31) ! nervous system development GO:0005783 (0.75) ! endoplasmic reticulum; GO:0005886 (0.55) ! plasma membrane GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 1702790-1710438 (17p13.3) Adrenal Gland: 8.64; Adipose - Subcutaneous: 7.79; Cells - Transformed fibroblasts: 7.48; Colon - Transverse: 7.12; Small Intestine - Terminal Ileum: 6.85; Nerve - Tibial: 5.68; Adipose - Visceral (Omentum): 5.52; Lung: 5.01; Bladder: 4.88; Cervix - Ectocervix: 4.74; Esophagus - Mucosa: 4.72; Fallopian Tube: 4.37; Vagina: 4.35; Breast - Mammary Tissue: 4.20; Cervix - Endocervix: 3.85; Ovary: 3.33; Artery - Tibial: 3.31; Minor Salivary Gland: 3.27; Artery - Coronary: 2.82; Esophagus - Muscularis: 2.69; MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCVSLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTLGKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSLAFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILGIRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD ZZEF1 Zinc finger ZZ-type and EF-hand domain-containing protein 1 ZZEF1_HUMAN (O43149-1) GO:0016740 (0.53) ! transferase activity; GO:0004842 (0.32) ! ubiquitin-protein transferase activity GO:0019538 (0.61) ! protein metabolic process; GO:0006464 (0.50) ! cellular protein modification process; GO:0032446 (0.36) ! protein modification by small protein conjugation; GO:0016567 (0.35) ! protein ubiquitination GO:0005634 (0.47) ! nucleus GO:0008270 ! zinc ion binding; GO:0005509 ! calcium ion binding; GO:0046872 ! metal ion binding 5 GO:0005509 ! calcium ion binding; GO:0008270 ! zinc ion binding 4004445-4143020 (17p13.2) Small Intestine - Terminal Ileum: 43.22; Esophagus - Muscularis: 31.11; Colon - Transverse: 28.12; Esophagus - Gastroesophageal Junction: 27.03; Spleen: 27.02; Thyroid: 25.73; Uterus: 25.32; Bladder: 25.27; Brain - Cerebellum: 25.15; Artery - Tibial: 24.35; Ovary: 23.78; Lung: 23.66; Brain - Cerebellar Hemisphere: 23.14; Pituitary: 23.03; Colon - Sigmoid: 22.73; Artery - Aorta: 22.63; Fallopian Tube: 22.41; Nerve - Tibial: 22.25; Prostate: 21.86; Skin - Sun Exposed (Lower leg): 21.84; MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAAAALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRELLEARGAGCSSEQFEEAFAQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLDIHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRSPEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRHLSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQINIKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQTVLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFALARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGKEDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGLVFAYNSSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEEWDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCRKDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQNPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVDKVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSLCTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVLFSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKTIVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLDVETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEFTDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAVSWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCPELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRKQAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADGIRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKESCEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSSSGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDVMDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELLTCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTALLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWMDECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQCSDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYAAKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVDGEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVTVPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPLKSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVLSAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRDVIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFTEKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDSHCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLLRDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLDEPTRICFLMAHDALNAPLHILRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQRWQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYAKQRRSKSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDILELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQVRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSGSQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVPHLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEYGLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNIAAISLAINYPNKATRLWNVEC SMTNL2 Smoothelin-like protein 2 SMTL2_HUMAN (Q2TAL5-1) GO:0008092 (0.77) ! cytoskeletal protein binding; GO:0003779 (0.42) ! actin binding; GO:1901363 (0.40) ! heterocyclic compound binding; GO:0097159 (0.40) ! organic cyclic compound binding; GO:0050660 (0.37) ! flavin adenine dinucleotide binding GO:0048856 (0.59) ! anatomical structure development; GO:0007010 (0.45) ! cytoskeleton organization; GO:0030029 (0.41) ! actin filament-based process; GO:0030036 (0.39) ! actin cytoskeleton organization; GO:0031032 (0.31) ! actomyosin structure organization GO:0044430 (0.50) ! cytoskeletal part; GO:0005856 (0.43) ! cytoskeleton; GO:0005886 (0.42) ! plasma membrane; GO:0042995 (0.38) ! cell projection; GO:0043234 (0.37) ! protein complex; GO:0044459 (0.36) ! plasma membrane part; GO:0030054 (0.36) ! cell junction; GO:0030055 (0.32) ! cell-substrate junction; GO:0005912 (0.31) ! adherens junction 2 4583999-4608319 (17p13.2) Muscle - Skeletal: 280.65; Kidney - Cortex: 25.27; Fallopian Tube: 14.21; Ovary: 9.72; Adipose - Visceral (Omentum): 9.01; Esophagus - Muscularis: 8.62; Heart - Left Ventricle: 7.63; Lung: 6.71; Cervix - Ectocervix: 6.30; Cervix - Endocervix: 5.88; Nerve - Tibial: 5.83; Heart - Atrial Appendage: 5.61; Uterus: 5.14; Esophagus - Gastroesophageal Junction: 5.07; Bladder: 4.64; Vagina: 3.63; Prostate: 3.11; Breast - Mammary Tissue: 2.85; Pituitary: 2.68; Adipose - Subcutaneous: 2.48; MEPAPDAQEARTVREALGRYEAALEGAVRALHEDMRGLQRGVERRVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSPPPAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDEASESEMRKTSNSCIMENGHQPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQPVTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPSEVITPWTPSPSEKNSSFTWSVPSSGYGAVTASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE TM4SF5 Transmembrane 4 L6 family member 5 T4S5_HUMAN (O14894-1) GO:0015370 (0.50) ! solute:sodium symporter activity; GO:0005326 (0.50) ! neurotransmitter transporter activity GO:0048856 (1.00) ! anatomical structure development; GO:2000227 (0.64) ! negative regulation of pancreatic A cell differentiation; GO:2000077 (0.64) ! negative regulation of type B pancreatic cell development; GO:0090104 (0.64) ! pancreatic epsilon cell differentiation; GO:0031018 (0.64) ! endocrine pancreas development; GO:0042246 (0.36) ! tissue regeneration; GO:0044765 (0.34) ! single-organism transport GO:0005887 ! integral component of plasma membrane GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 4771884-4783213 (17p13.2) Liver: 126.20; Small Intestine - Terminal Ileum: 53.03; Colon - Transverse: 10.47; Stomach: 8.42; Kidney - Cortex: 8.34; Pancreas: 0.33; Testis: 0.20; Adrenal Gland: 0.12; Colon - Sigmoid: 0.11; Cervix - Endocervix: 0.09; MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH VMO1 Vitelline membrane outer layer protein 1 homolog VMO1_HUMAN (Q7Z5L0-1) GO:0016787 (0.53) ! hydrolase activity; GO:0008061 (0.36) ! chitin binding; GO:0004568 (0.36) ! chitinase activity GO:0048856 (0.35) ! anatomical structure development GO:0070062 (1.00) ! extracellular exosome GO:0070062 ! extracellular exosome GO:0005576 ! extracellular region 3 4785285-4786433 (17p13.2) Pituitary: 36.65; Spleen: 27.55; Lung: 12.54; Artery - Aorta: 11.17; Artery - Coronary: 7.36; Nerve - Tibial: 6.98; Cervix - Endocervix: 6.64; Liver: 5.87; Minor Salivary Gland: 5.44; Brain - Spinal cord (cervical c-1): 5.05; Adipose - Visceral (Omentum): 4.66; Prostate: 4.35; Adipose - Subcutaneous: 3.86; Artery - Tibial: 3.81; Vagina: 3.72; Brain - Cerebellum: 3.67; Brain - Cerebellar Hemisphere: 3.66; Brain - Hypothalamus: 3.39; Small Intestine - Terminal Ileum: 3.22; Cells - Transformed fibroblasts: 3.14; MERGAGAKLLPLLLLLRATGFTCAQTDGRNGYTAVIEVTSGGPWGDWAWPEMCPDGFFASGFSLKVEPPQGIPGDDTALNGIRLHCARGNVLGNTHVVESQSGSWGEWSEPLWCRGGAYLVAFSLRVEAPTTLGDNTAANNVRFRCSDGEELQGPGLSWGDFGDWSDHCPKGACGLQTKIQGPRGLGDDTALNDARLFCCRS C17orf100 Uncharacterized protein C17orf100 CQ100_HUMAN (A8MU93-1) GO:0030308 (0.84) ! negative regulation of cell growth GO:0005634 (0.81) ! nucleus; GO:0043234 (0.77) ! protein complex; GO:0016459 (0.76) ! myosin complex; GO:0031988 (0.60) ! membrane-bounded vesicle; GO:0042995 (0.44) ! cell projection; GO:0016023 (0.44) ! cytoplasmic, membrane-bounded vesicle 1 6651718-6693202 (17p13.1) Pituitary: 3.85; Skin - Not Sun Exposed (Suprapubic): 2.29; Skin - Sun Exposed (Lower leg): 2.19; Testis: 2.12; Thyroid: 1.96; Esophagus - Mucosa: 1.91; Brain - Nucleus accumbens (basal ganglia): 1.24; Spleen: 1.17; Cells - EBV-transformed lymphocytes: 1.11; Brain - Cerebellum: 0.78; Brain - Hypothalamus: 0.77; Brain - Cerebellar Hemisphere: 0.77; Brain - Frontal Cortex (BA9): 0.74; Brain - Cortex: 0.73; Brain - Caudate (basal ganglia): 0.72; Vagina: 0.65; Prostate: 0.64; Fallopian Tube: 0.60; Minor Salivary Gland: 0.60; Small Intestine - Terminal Ileum: 0.58; MASARGAKQSSPRVGTTRYTETSTVRVETSSHRVETSSRRVETSQRRSEGPSLSPSGKRLPRILEASSRHVESSSQRTETTSRHVRASSLRVETSLHCAESPTPRPSRPPARTKKRPDEMLLPKGHQGARALSQDRKASSCQPASQLPGGPIIFGFMETNHKSM TMEM256 Transmembrane protein 256 TM256_HUMAN (Q8N2U0-1) GO:0022892 (0.57) ! substrate-specific transporter activity; GO:0017128 (0.55) ! phospholipid scramblase activity; GO:0008865 (0.45) ! fructokinase activity; GO:0004454 (0.45) ! ketohexokinase activity GO:0046835 (0.57) ! carbohydrate phosphorylation; GO:0006810 (0.46) ! transport; GO:0044351 (0.43) ! macropinocytosis GO:0070062 (0.51) ! extracellular exosome GO:0070062 ! extracellular exosome GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 7402975-7404137 (17p13.1) Cells - EBV-transformed lymphocytes: 125.35; Nerve - Tibial: 114.20; Cervix - Endocervix: 101.50; Cervix - Ectocervix: 98.81; Ovary: 92.08; Fallopian Tube: 88.67; Prostate: 86.75; Breast - Mammary Tissue: 85.71; Adipose - Visceral (Omentum): 83.41; Cells - Transformed fibroblasts: 83.03; Uterus: 82.64; Small Intestine - Terminal Ileum: 81.49; Brain - Spinal cord (cervical c-1): 80.98; Adipose - Subcutaneous: 77.24; Bladder: 75.93; Vagina: 74.54; Artery - Coronary: 71.48; Stomach: 68.31; Adrenal Gland: 68.28; Spleen: 67.69; MAGPAAAFRRLGALSGAAALGFASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQTLAPAGGTLLLLGWLALAL SPEM2 Uncharacterized protein SPEM2 SPEM2_HUMAN (Q0P670-1) GO:0043234 (0.57) ! protein complex; GO:0044428 (0.31) ! nuclear part GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 7425615-7427568 (17p13.1) MENQLWHNTVRCCNQYQESPHDAEDILLLLLGLIVLVNIGINVATMMWHGLQNALDKMIDWATQKNEIQASESPPSGPPDKAQDVHIHCILDPVQVKMSRPTQYSSFSCHHFSNHHSSSLLRCVRRRRRRHRRCRRRCCNHQQRPQNYRQIPHSHSVFRNPHRSQKMSQLHRVPFFDQEDPDSYLEEEDNLPFPYPKYPRRGWGGFYQRAGLPSNVGLWGHQGGILASLPPPSLYLSPELRCMPKRVEARSELRLQSYGRHGSQSRLWGNVEAEQWASSPPPPHRLPPNPSWVPVGHSPYPSVGWMLYDSWDQRRRGTEGFERPPASVSRNARPEAQGCREHHSPQSHQQSLLGHAYGQSHRSPHPSTEPLGYSSQDPREVRRRAADWAEALPAWRPLTTSASLTVLDEASHQRTPAPSSVLVPHSSQPWPKVQAADPAPPPTMFVPLSRNPGGNANYQVYDSLELKRQVQKSRARSSSLPPASTSTLRPSLHRSQTEKLN CDRT15 CMT1A duplicated region transcript 15 protein CDRTF_HUMAN (Q96T59-1) GO:0030234 (0.57) ! enzyme regulator activity; GO:0016887 (0.55) ! ATPase activity; GO:0003777 (0.55) ! microtubule motor activity; GO:0043178 (0.49) ! alcohol binding; GO:0032934 (0.49) ! sterol binding; GO:0015248 (0.49) ! sterol transporter activity; GO:0008047 (0.49) ! enzyme activator activity; GO:0071814 (0.40) ! protein-lipid complex binding; GO:0070405 (0.40) ! ammonium ion binding; GO:0042277 (0.40) ! peptide binding GO:0006810 (0.68) ! transport; GO:0071702 (0.55) ! organic substance transport; GO:0006928 (0.55) ! movement of cell or subcellular component; GO:0065008 (0.53) ! regulation of biological quality; GO:0044707 (0.53) ! single-multicellular organism process; GO:0055092 (0.49) ! sterol homeostasis; GO:0045940 (0.49) ! positive regulation of steroid metabolic process; GO:0042157 (0.49) ! lipoprotein metabolic process; GO:0034377 (0.49) ! plasma lipoprotein particle assembly; GO:0016101 (0.49) ! diterpenoid metabolic process; GO:0015914 (0.49) ! phospholipid transport; GO:0010872 (0.49) ! regulation of cholesterol esterification; GO:0007265 (0.46) ! Ras protein signal transduction; GO:0045595 (0.44) ! regulation of cell differentiation; GO:1904729 (0.40) ! regulation of intestinal lipid absorption; GO:1902653 (0.40) ! secondary alcohol biosynthetic process; GO:0090208 (0.40) ! positive regulation of triglyceride metabolic process; GO:0061365 (0.40) ! positive regulation of triglyceride lipase activity; GO:0055090 (0.40) ! acylglycerol homeostasis; GO:0051004 (0.40) ! regulation of lipoprotein lipase activity; GO:0050996 (0.40) ! positive regulation of lipid catabolic process; GO:0050727 (0.40) ! regulation of inflammatory response; GO:0046889 (0.40) ! positive regulation of lipid biosynthetic process; GO:0045923 (0.40) ! positive regulation of fatty acid metabolic process; GO:0042304 (0.40) ! regulation of fatty acid biosynthetic process; GO:0035023 (0.40) ! regulation of Rho protein signal transduction; GO:0034381 (0.40) ! plasma lipoprotein particle clearance; GO:0032488 (0.40) ! Cdc42 protein signal transduction; GO:0032374 (0.40) ! regulation of cholesterol transport; GO:0032102 (0.40) ! negative regulation of response to external stimulus; GO:0031348 (0.40) ! negative regulation of defense response; GO:0031331 (0.40) ! positive regulation of cellular catabolic process; GO:0031328 (0.40) ! positive regulation of cellular biosynthetic process; GO:0030299 (0.40) ! intestinal cholesterol absorption; GO:0016126 (0.40) ! sterol biosynthetic process; GO:0010896 (0.40) ! regulation of triglyceride catabolic process; GO:0006897 (0.40) ! endocytosis; GO:0010769 (0.38) ! regulation of cell morphogenesis involved in differentiation; GO:0030705 (0.36) ! cytoskeleton-dependent intracellular transport; GO:0007018 (0.36) ! microtubule-based movement GO:0043234 (0.54) ! protein complex; GO:0044430 (0.47) ! cytoskeletal part; GO:0005886 (0.47) ! plasma membrane; GO:0005871 (0.44) ! kinesin complex; GO:0070062 (0.35) ! extracellular exosome; GO:0005829 (0.33) ! cytosol; GO:0005634 (0.33) ! nucleus 1 14235673-14236862 (17p12) Testis: 18.64; Spleen: 0.41; Small Intestine - Terminal Ileum: 0.30; Brain - Cerebellum: 0.24; Cells - EBV-transformed lymphocytes: 0.24; Esophagus - Mucosa: 0.23; Prostate: 0.20; Skin - Not Sun Exposed (Suprapubic): 0.20; Skin - Sun Exposed (Lower leg): 0.19; Brain - Cerebellar Hemisphere: 0.19; Cervix - Ectocervix: 0.17; Cells - Transformed fibroblasts: 0.17; Lung: 0.17; Fallopian Tube: 0.16; Vagina: 0.16; Colon - Transverse: 0.16; Liver: 0.15; Thyroid: 0.14; Minor Salivary Gland: 0.14; Artery - Aorta: 0.14; MFSCCFPTSRGCCFRNGGSESLFRRCRRRLIPHPRRLSPVVIRRIQVPQDSLGQALAGQATPEIPLGLQLHTVLVQEIQELIEAQTLAPGPCAEVRALPAPAAEPEPAWEEAPPERALELEGAPAKDQTNEELPEITEVPESIKRRLGRRVPAATPAPRGNLLLQAWMRVHSWASRLFAPNVLPGTGP LRRC75A Leucine-rich repeat-containing protein 75A LR75A_HUMAN (Q8NAA5-1) GO:0030234 (0.37) ! enzyme regulator activity; GO:0004857 (0.36) ! enzyme inhibitor activity GO:0009057 (0.39) ! macromolecule catabolic process; GO:0090304 (0.37) ! nucleic acid metabolic process; GO:0044265 (0.37) ! cellular macromolecule catabolic process; GO:0048583 (0.36) ! regulation of response to stimulus; GO:0022603 (0.36) ! regulation of anatomical structure morphogenesis; GO:0048646 (0.35) ! anatomical structure formation involved in morphogenesis; GO:1901342 (0.34) ! regulation of vasculature development; GO:0016071 (0.34) ! mRNA metabolic process; GO:0006401 (0.34) ! RNA catabolic process; GO:0001525 (0.33) ! angiogenesis GO:0043234 (0.58) ! protein complex; GO:0005886 (0.45) ! plasma membrane; GO:0044421 (0.38) ! extracellular region part; GO:0005634 (0.37) ! nucleus; GO:0031988 (0.36) ! membrane-bounded vesicle; GO:0070062 (0.35) ! extracellular exosome; GO:0031224 (0.32) ! intrinsic component of membrane; GO:0044428 (0.31) ! nuclear part 2 16441577-16492153 (17p11.2) MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRAGAGMPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFRNLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRKPQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTRAVLRDLTDILKDPSKFPNVTWIDLGNNVDIFSLPQPFLLSLRKRSPKQGHLPTILELGEGPGSGEEVREGTVGQEDPGGGPVAPAEDHHEGKETVAAAQT SPECC1 Cytospin-B CYTSB_HUMAN (Q5M775-1) GO:0008092 (0.53) ! cytoskeletal protein binding; GO:0046983 (0.45) ! protein dimerization activity; GO:0042802 (0.45) ! identical protein binding; GO:0019899 (0.45) ! enzyme binding; GO:0003779 (0.43) ! actin binding; GO:0042805 (0.42) ! actinin binding; GO:0005198 (0.41) ! structural molecule activity; GO:1901363 (0.40) ! heterocyclic compound binding; GO:0097367 (0.40) ! carbohydrate derivative binding; GO:0097159 (0.40) ! organic cyclic compound binding; GO:0032403 (0.40) ! protein complex binding; GO:0051015 (0.38) ! actin filament binding; GO:0044389 (0.38) ! ubiquitin-like protein ligase binding; GO:0003676 (0.38) ! nucleic acid binding; GO:0001948 (0.38) ! glycoprotein binding; GO:0045296 (0.37) ! cadherin binding; GO:0017166 (0.36) ! vinculin binding; GO:0003723 (0.35) ! RNA binding; GO:0008013 (0.32) ! beta-catenin binding GO:0048856 (0.51) ! anatomical structure development; GO:0007010 (0.48) ! cytoskeleton organization; GO:0051179 (0.45) ! localization; GO:0006928 (0.43) ! movement of cell or subcellular component; GO:0030029 (0.42) ! actin filament-based process; GO:0009653 (0.42) ! anatomical structure morphogenesis; GO:0030036 (0.41) ! actin cytoskeleton organization; GO:0051641 (0.39) ! cellular localization; GO:0022607 (0.37) ! cellular component assembly; GO:0030030 (0.34) ! cell projection organization; GO:0008104 (0.33) ! protein localization; GO:0032989 (0.32) ! cellular component morphogenesis; GO:0032879 (0.32) ! regulation of localization; GO:0009888 (0.32) ! tissue development; GO:0048513 (0.31) ! animal organ development; GO:0040011 (0.31) ! locomotion GO:0044430 (0.66) ! cytoskeletal part; GO:0030054 (0.51) ! cell junction; GO:0005856 (0.51) ! cytoskeleton; GO:0005886 (0.48) ! plasma membrane; GO:0044459 (0.47) ! plasma membrane part; GO:0042995 (0.45) ! cell projection; GO:0005912 (0.45) ! adherens junction; GO:0030055 (0.41) ! cell-substrate junction; GO:0005924 (0.38) ! cell-substrate adherens junction; GO:0005911 (0.36) ! cell-cell junction; GO:0044449 (0.35) ! contractile fiber part; GO:0044448 (0.34) ! cell cortex part; GO:0005925 (0.34) ! focal adhesion; GO:0005913 (0.33) ! cell-cell adherens junction GO:0016020 ! membrane; GO:0005634 ! nucleus 5 20009344-20319026 (17p11.2) High: stomach 2 (glandular cells);stomach 1 (glandular cells);epididymis (glandular cells);gallbladder (glandular cells);rectum (glandular cells);cervix, uterine (glandular cells);Medium: colon (endothelial cells; glandular cells);kidney (cells in glomeruli; cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (neuronal cells);tonsil (germinal center cells; non-germinal center cells);adrenal gland (glandular cells);endometrium 1 (cells in endometrial stroma; glandular cells);endometrium 2 (cells in endometrial stroma; glandular cells);salivary gland (glandular cells);smooth muscle (smooth muscle cells);duodenum (glandular cells);cerebral cortex (neuronal cells; neuropil);lymph node (germinal center cells; non-germinal center cells);placenta (trophoblastic cells); Brain - Spinal cord (cervical c-1): 19.62; Testis: 17.61; Artery - Aorta: 17.25; Artery - Coronary: 13.11; Ovary: 12.19; Brain - Frontal Cortex (BA9): 12.16; Artery - Tibial: 12.14; Brain - Cortex: 11.96; Brain - Substantia nigra: 11.32; Brain - Hippocampus: 10.12; Spleen: 9.58; Uterus: 9.46; Brain - Cerebellum: 9.33; Brain - Hypothalamus: 9.04; Adipose - Subcutaneous: 8.87; Brain - Cerebellar Hemisphere: 8.75; Nerve - Tibial: 8.36; Brain - Amygdala: 8.30; Brain - Anterior cingulate cortex (BA24): 8.08; Brain - Putamen (basal ganglia): 7.33; MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET NATD1 NATD1 NATD1_HUMAN (Q8N6N6-1) GO:0004402 (0.33) ! histone acetyltransferase activity GO:0006473 (0.68) ! protein acetylation; GO:0018393 (0.44) ! internal peptidyl-lysine acetylation; GO:0001702 (0.37) ! gastrulation with mouth forming second; GO:0016573 (0.35) ! histone acetylation; GO:0006474 (0.35) ! N-terminal protein amino acid acetylation GO:0043234 (0.64) ! protein complex; GO:0031248 (0.55) ! protein acetyltransferase complex; GO:0044428 (0.33) ! nuclear part; GO:0044427 (0.33) ! chromosomal part GO:0005515 ! protein binding 2 GO:0005515 ! protein binding 21238870-21253410 (17p11.2) MAHSAAAVPLGALEQGCPIRVEHDRRRRQFTVRLNGCHDRAVLLYEYVGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENPLPQYLERLQP LYRM9 LYR motif-containing protein 9 LYRM9_HUMAN (A8MSI8-1) GO:0008137 (0.52) ! NADH dehydrogenase (ubiquinone) activity GO:0022607 (0.41) ! cellular component assembly; GO:0043623 (0.36) ! cellular protein complex assembly; GO:0070271 (0.32) ! protein complex biogenesis; GO:0033108 (0.32) ! mitochondrial respiratory chain complex assembly GO:0005739 (0.53) ! mitochondrion; GO:0044421 (0.42) ! extracellular region part; GO:0070062 (0.40) ! extracellular exosome; GO:0005576 (0.40) ! extracellular region 2 27878314-27894752 (17q11.2) Brain - Nucleus accumbens (basal ganglia): 49.65; Brain - Anterior cingulate cortex (BA24): 47.32; Brain - Frontal Cortex (BA9): 43.70; Nerve - Tibial: 43.53; Brain - Cortex: 39.62; Brain - Amygdala: 35.88; Thyroid: 33.59; Adrenal Gland: 32.92; Pituitary: 31.76; Brain - Hippocampus: 31.04; Brain - Hypothalamus: 30.89; Ovary: 29.91; Brain - Caudate (basal ganglia): 29.16; Testis: 24.35; Brain - Putamen (basal ganglia): 24.18; Cervix - Endocervix: 22.66; Brain - Cerebellar Hemisphere: 22.33; Brain - Cerebellum: 21.83; Brain - Substantia nigra: 21.66; Uterus: 21.61; MAPLPGAELVRRPLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWIMNKYKKQN RAB34 Ras-related protein Rab-34, isoform NARR NARR_HUMAN (P0DI83-1) GO:0043234 (0.43) ! protein complex; GO:0031224 (0.36) ! intrinsic component of membrane GO:0005730 ! nucleolus; GO:0005634 ! nucleus 5 28714281-28718429 (17q11.2) High: stomach 2 (glandular cells);testis (Leydig cells);stomach 1 (glandular cells);parathyroid gland (glandular cells);small intestine (glandular cells);duodenum (glandular cells);prostate (glandular cells);pancreas (islets of Langerhans);Medium: colon (glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);kidney (cells in tubules);testis (cells in seminiferous ducts);thyroid gland (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);endometrium 2 (glandular cells);smooth muscle (smooth muscle cells);cerebral cortex (neuronal cells; neuropil);placenta (decidual cells; trophoblastic cells);bronchus (respiratory epithelial cells); Artery - Aorta: 196.70; Ovary: 190.40; Cervix - Endocervix: 177.00; Cervix - Ectocervix: 173.35; Uterus: 170.70; Cells - Transformed fibroblasts: 166.80; Fallopian Tube: 147.30; Artery - Tibial: 142.70; Artery - Coronary: 136.20; Nerve - Tibial: 130.30; Bladder: 117.40; Colon - Sigmoid: 117.20; Prostate: 117.05; Esophagus - Gastroesophageal Junction: 116.50; Thyroid: 107.70; Esophagus - Muscularis: 105.00; Vagina: 100.00; Adrenal Gland: 87.36; Lung: 77.58; Breast - Mammary Tissue: 71.19; MVGQPQPRDDVGSPRPRVIVGTIRPRVIVGTIRPRVIVGSARARPPPDGTPRPQLAAEESPRPRVIFGTPRARVILGSPRPRVIVSSPWPAVVVASPRPRTPVGSPWPRVVVGTPRPRVIVGSPRARVADADPASAPSQGALQGRRQDEHSGTRAEGSRPGGAAPVPEEGGRFARAQRLPPPRHLRLPGAPDRHRGQI FAM222B FAM222B F222B_HUMAN (Q8WU58-1) GO:0003676 (0.52) ! nucleic acid binding; GO:0043169 (0.32) ! cation binding GO:0005654 (1.00) ! nucleoplasm GO:0005654 ! nucleoplasm 2 28755978-28855232 (17q11.2) High: stomach 2 (glandular cells);fallopian tube (glandular cells);urinary bladder (urothelial cells);small intestine (glandular cells);colon (glandular cells);gallbladder (glandular cells);rectum (glandular cells);duodenum (glandular cells);Medium: stomach 1 (glandular cells);seminal vesicle (glandular cells);lung (macrophages);esophagus (squamous epithelial cells);kidney (cells in glomeruli; cells in tubules);testis (cells in seminiferous ducts; Leydig cells);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);endometrium 2 (cells in endometrial stroma; glandular cells);epididymis (glandular cells);endometrium 1 (glandular cells);thyroid gland (glandular cells);salivary gland (glandular cells); Testis: 48.34; Brain - Cerebellar Hemisphere: 22.43; Muscle - Skeletal: 21.75; Brain - Cerebellum: 20.01; Esophagus - Muscularis: 19.35; Bladder: 17.00; Esophagus - Gastroesophageal Junction: 15.90; Pituitary: 15.48; Cervix - Endocervix: 15.15; Minor Salivary Gland: 14.29; Prostate: 14.15; Vagina: 13.69; Artery - Tibial: 13.63; Thyroid: 13.61; Cervix - Ectocervix: 12.95; Colon - Sigmoid: 12.72; Ovary: 12.24; Small Intestine - Terminal Ileum: 12.15; Lung: 12.14; Artery - Aorta: 12.04; MLACLPGPGDLSFQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARLLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQPMAQTQGLVHPQALAHQGLQHPHNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRVPTGYPSDLKPVTWNQHQLAHLQQMCSEASGTPAPGLTGKHAAGRELAGPGFVGKAPAYPQELCLAQSFHLKPPLEKPTPSPPVNGMAAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLAMPFHGGQPTGAPLDCAAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGNRAPDPTESRSLHIQHPGYR EFCAB5 EF-hand calcium-binding domain-containing protein 5 EFCB5_HUMAN (A4FU69-1) GO:0005509 ! calcium ion binding; GO:0046872 ! metal ion binding 3 GO:0005509 ! calcium ion binding 29929200-30108452 (17q11.2) Testis: 11.52; Brain - Cerebellar Hemisphere: 0.96; Brain - Cerebellum: 0.90; Brain - Frontal Cortex (BA9): 0.36; Nerve - Tibial: 0.31; Brain - Substantia nigra: 0.30; Brain - Cortex: 0.29; Brain - Anterior cingulate cortex (BA24): 0.24; Colon - Transverse: 0.23; Brain - Nucleus accumbens (basal ganglia): 0.21; Brain - Hypothalamus: 0.20; Brain - Spinal cord (cervical c-1): 0.20; Brain - Hippocampus: 0.20; Thyroid: 0.19; Small Intestine - Terminal Ileum: 0.19; Bladder: 0.17; Brain - Caudate (basal ganglia): 0.16; Spleen: 0.15; Brain - Amygdala: 0.15; Colon - Sigmoid: 0.14; MNESASQEELRPAQENRKEDKERKWNLTEVKELHETLQSVPDVPVKEDTNSVVEKAMDEIKSQELNLEGQRKISPGSIKDSKTEASGNIAIRKSAKVIFALDETELKSKPEHTWKKNLFERMEARAQAMQQKIIDKENLKKELEKKAEKKLPRDNLAKEWFNTDSMTLNNTAYLLDKLLPTLVPGVENMLTQVEKKKVLTEADTPSKFDPINYLGEYLIRNNPNYIKDPGMSGYQRLMKEVTEDLKIYVPDTICNRVSKMKENVKQNRKQRESIDKIIVKVANTRKQALQEQFDEWILDPKGMIPKSVIQNVLQEFFQNPDFKLGSHCKQLDITDSTEPRLNKMEFTEYISSHIKDLKSEMFEELLKHLCHSADEFREVIKADMRRQMFAELFLHCDHGKVGFLDRQRTLALLELFYDHSSQMLRSLLRNPRQWPFIEFEEINLTELWGDMDNQKHIYEGFDKVLLEMNTLLSANHASKTQSKLLESPDQPKLNEQRTSTPSPNPPEQQRGVTAEQGPQRISIEEQQQGKKPTAEQELYIESVIEPGTHTESTLEQGSSRRLLTEQETHRESTTEQGQHKGSIEGQGPRRVSVSEQGSSRESVAEQGSRRESIAEQDRHKGSVAEQGSRRMSAAEQGSLRESVIEEPYQKSEQGPYGEIISEEQEDIGSTSQSRKDSILKSTKYGEPITSEYIEVPLQEKRSWEQTYEEEIFLSSELQEEVPTLSRKDHFPETTKKEVQKDKPCEPKSQKIEGKSWSGEFFTCNWKMKYVTFEDEEQANLIYGNSRFTDLHSIIRNIQSCKEVKGRTAFNGVSFNLLQFVQLLETFVGEDAPLSVSETLTSFFKEGYVETEQEKMNALEQFSQNAFQVRQRLLLEAIFQKWDSDGSGFLDLKEVDELLYTYKEGMEKESMKKAKLHIQFPKPHPGHEVRLSSKQFQNYIELVVSELRGNEDQVLESVVEFLMNALERSHIESLRNSARRKWLHQIQCAAETSGVSLEPVYSETFKALMQDAEAHGNKKISAHISLLEENLLLPEKGNVLLRNVACTLDDAQFVLNRVLYRDMKGISFTVVDEGKPIHVPQVQYHGNIFFWNQSRNKHDYNGSFLALPLQDAYMRIFGVLAVDTLRDPHEINIFLPHEIRFYQGVANVFSTAYHYVHSREHILHIVITGIGWLYDVTSSITSITTYFVEPSPAQDSDYVLRNMMVTGQLGLTEIHKNPPTIHRKSCIFRDFLFKCTDSSEVVLASACGETHIVVPLRERTGEALGVLDFNIGQNRMLLCQEYKDLQKMMKVVQVACYEILGEFSGEIKKKYILEIENVREVQRAGILFFRIMLLELQESIQLLNSMEFVSLLLYDHTLVTEPNSPQDSKSMELEANVKLVRDILKAVILFFHPELEFSSDFGSWDKCKFYVNKYLVNNICAFDPTAKHVEVNVQLIDEYIRDHSRTEVWKFGNVVIEHLYHWIHICSALMKITKQLNSGITPPLPSKTDNYMYAKMPGEGLQEK EVI2B EVI2B EVI2B_HUMAN (P34910-1) GO:0005198 (0.37) ! structural molecule activity GO:0051179 (0.43) ! localization; GO:0051234 (0.42) ! establishment of localization; GO:0006810 (0.41) ! transport; GO:0051649 (0.39) ! establishment of localization in cell; GO:0051641 (0.39) ! cellular localization; GO:0046907 (0.37) ! intracellular transport; GO:0071702 (0.34) ! organic substance transport; GO:0051169 (0.33) ! nuclear transport; GO:0050658 (0.32) ! RNA transport; GO:0045184 (0.32) ! establishment of protein localization GO:0005887 (1.00) ! integral component of plasma membrane Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}. GO:2000035 ! regulation of stem cell division; GO:0030854 ! positive regulation of granulocyte differentiation; GO:0061515 ! myeloid cell development; GO:0005887 ! integral component of plasma membrane; GO:0043066 ! negative regulation of apoptotic process; GO:0071157 ! negative regulation of cell cycle arrest; GO:0045660 ! positive regulation of neutrophil differentiation GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 5 GO:0030854 ! positive regulation of granulocyte differentiation; GO:0043066 ! negative regulation of apoptotic process; GO:0045660 ! positive regulation of neutrophil differentiation; GO:0061515 ! myeloid cell development; GO:0071157 ! negative regulation of cell cycle arrest; GO:2000035 ! regulation of stem cell division 31303766-31314112 (17q11.2) High: cerebellum (cells in molecular layer; Purkinje cells);lymph node (germinal center cells; non-germinal center cells);hippocampus (neuronal cells);caudate (neuronal cells);spleen (cells in red pulp; cells in white pulp);bone marrow (hematopoietic cells);tonsil (germinal center cells; non-germinal center cells);salivary gland (glandular cells);appendix (lymphoid tissue);colon (peripheral nerve/ganglion);lung (macrophages);cerebral cortex (neuronal cells);Medium: stomach 2 (glandular cells);small intestine (glandular cells);stomach 1 (glandular cells);liver (hepatocytes);bronchus (respiratory epithelial cells);testis (cells in seminiferous ducts);epididymis (glandular cells);endometrium 1 (glandular cells); Whole Blood: 618.20; Spleen: 186.30; Cells - EBV-transformed lymphocytes: 162.50; Lung: 65.21; Small Intestine - Terminal Ileum: 30.21; Cells - Transformed fibroblasts: 25.41; Brain - Spinal cord (cervical c-1): 19.71; Adipose - Visceral (Omentum): 18.33; Adipose - Subcutaneous: 15.60; Colon - Transverse: 13.51; Minor Salivary Gland: 13.36; Artery - Coronary: 13.18; Bladder: 12.37; Artery - Aorta: 10.57; Nerve - Tibial: 9.02; Cervix - Endocervix: 8.99; Breast - Mammary Tissue: 8.41; Brain - Substantia nigra: 8.33; Fallopian Tube: 7.94; Prostate: 7.57; MDPKYFILILFCGHLNNTFFSKTETITTEKQSQPTLFTSSMSQVLANSQNTTGNPLGQPTQFSDTFSGQSISPAKVTAGQPTPAVYTSSEKPEAHTSAGQPLAYNTKQPTPIANTSSQQAVFTSARQLPSARTSTTQPPKSFVYTFTQQSSSVQIPSRKQITVHNPSTQPTSTVKNSPRSTPGFILDTTSNKQTPQKNNYNSIAAILIGVLLTSMLVAIIIIVLWKCLRKPVLNDQNWAGRSPFADGETPDICMDNIRENEISTKRTSIISLTPWKPSKSTLLADDLEIKLFESSENIEDSNNPKTEKIKDQVNGTSEDSADGSTVGTAVSSSDDADLPPPPPLLDLEGQESNQSDKPTMTIVSPLPNDSTSLPPSLDCLNQDCGDHKSEIIQSFPPLDSLNLPLPPVDFMKNQEDSNLEIQCQEFSIPPNSDQDLNESLPPPPAELL LRRC37B Leucine-rich repeat-containing protein 37B LR37B_HUMAN (Q96QE4-1) GO:0005215 (0.35) ! transporter activity; GO:0022892 (0.34) ! substrate-specific transporter activity GO:0051179 (0.35) ! localization; GO:0051641 (0.34) ! cellular localization; GO:0006810 (0.34) ! transport; GO:0051649 (0.33) ! establishment of localization in cell; GO:0008104 (0.33) ! protein localization; GO:0048583 (0.32) ! regulation of response to stimulus; GO:0006886 (0.32) ! intracellular protein transport; GO:0007166 (0.31) ! cell surface receptor signaling pathway GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 32007872-32053504 (17q11.2) Medium: lymph node (non-germinal center cells);placenta (decidual cells);small intestine (glandular cells);stomach 1 (glandular cells);bone marrow (hematopoietic cells);bronchus (respiratory epithelial cells);tonsil (non-germinal center cells);parathyroid gland (glandular cells);skeletal muscle (myocytes);vagina (squamous epithelial cells);salivary gland (glandular cells);colon (glandular cells);gallbladder (glandular cells);stomach 2 (glandular cells);heart muscle (myocytes);esophagus (squamous epithelial cells);oral mucosa (squamous epithelial cells);rectum (glandular cells);duodenum (glandular cells);Low: placenta (trophoblastic cells); Testis: 27.32; Brain - Cerebellar Hemisphere: 26.18; Brain - Cerebellum: 23.46; Ovary: 12.76; Skin - Sun Exposed (Lower leg): 11.04; Pituitary: 10.86; Uterus: 10.43; Skin - Not Sun Exposed (Suprapubic): 10.34; Cervix - Endocervix: 9.71; Nerve - Tibial: 9.69; Fallopian Tube: 8.79; Cervix - Ectocervix: 8.51; Vagina: 8.05; Bladder: 7.34; Brain - Frontal Cortex (BA9): 7.12; Lung: 7.06; Brain - Cortex: 6.87; Brain - Spinal cord (cervical c-1): 6.51; Artery - Aorta: 6.49; Artery - Tibial: 6.39; MSWLRFWGPWPLLTWQLLSLLVKEAQPLVWVKDPLQLTSNPLGPPEPWSSRSSHLPWESPHAPAPPAAPGDFDYLGPSASSQMSALPQEPTENLAPFLKELDSAGELPLGPEPFLAAHQDLNDKRTPEERLPEVVPLLNRDQNQALVQLPRLKWVQTTDLDRAAGHQADEILVPLDSKVSRPTKFVVSPKNLKKDLAERWSLPEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPGSLPPELRVNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQQEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKNETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATVQPLDLELSITTEPTTEVKPSPTTEETSAQPPDPGLAITPEPTTEIGHSTALEKTRAPHPDQVQTLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTSTNICELCTCGDETLSCVGLSPKQRLRQVPVPEPDTYNGIFTTLNFQGNYISYLDGNVWKAYSWTEKLILSENYLTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLITKLSLGTFQAWHGMQFLHNLILNRNPLTTVEDPYLFELPALKYLDMGTTHITLTTLKNILTMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNTACLTNSIHCPEEASVGNPEGAFMKMLQARKQHMSTQLTIESEAPSDSSGINLSGFGGDQLEIQLTEQLRSLIPNEDVRKFMSHVIRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQKTNYINENMEQNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEKYKDNPSISGA TMEM98 Transmembrane protein 98 TMM98_HUMAN (Q9Y2Y6-1) GO:0046914 (0.50) ! transition metal ion binding; GO:0046906 (0.50) ! tetrapyrrole binding; GO:0016676 (0.50) ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor; GO:0015078 (0.50) ! hydrogen ion transmembrane transporter activity; GO:0015002 (0.50) ! heme-copper terminal oxidase activity; GO:0009055 (0.50) ! electron carrier activity GO:0098662 (0.50) ! inorganic cation transmembrane transport; GO:0046034 (0.50) ! ATP metabolic process; GO:0045333 (0.50) ! cellular respiration; GO:0016310 (0.50) ! phosphorylation; GO:0015672 (0.50) ! monovalent inorganic cation transport; GO:0006818 (0.50) ! hydrogen transport GO:0005634 (0.52) ! nucleus; GO:0005783 (0.48) ! endoplasmic reticulum GO:0005783 ! endoplasmic reticulum GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 32927910-32945106 (17q11.2) Ovary: 109.90; Nerve - Tibial: 62.17; Uterus: 60.80; Fallopian Tube: 51.22; Cells - Transformed fibroblasts: 45.72; Cervix - Endocervix: 45.38; Artery - Aorta: 39.12; Cervix - Ectocervix: 36.70; Prostate: 35.99; Brain - Spinal cord (cervical c-1): 30.36; Vagina: 28.84; Thyroid: 28.33; Small Intestine - Terminal Ileum: 27.55; Stomach: 27.26; Colon - Transverse: 26.89; Lung: 26.77; Artery - Coronary: 23.72; Adipose - Visceral (Omentum): 23.69; Minor Salivary Gland: 23.41; Adrenal Gland: 21.43; METVVIVAIGVLATIFLASFAALVLVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI FNDC8 Fibronectin type III domain-containing protein 8 FNDC8_HUMAN (Q8TC99-1) GO:0097367 (0.51) ! carbohydrate derivative binding; GO:1901363 (0.50) ! heterocyclic compound binding; GO:0097159 (0.50) ! organic cyclic compound binding; GO:0035639 (0.49) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.49) ! adenyl ribonucleotide binding; GO:0032550 (0.49) ! purine ribonucleoside binding; GO:0016740 (0.37) ! transferase activity; GO:0004872 (0.37) ! receptor activity; GO:0016787 (0.35) ! hydrolase activity; GO:0004888 (0.35) ! transmembrane signaling receptor activity; GO:0004672 (0.35) ! protein kinase activity; GO:0008186 (0.31) ! RNA-dependent ATPase activity; GO:0008026 (0.31) ! ATP-dependent helicase activity; GO:0003724 (0.31) ! RNA helicase activity GO:0048856 (0.54) ! anatomical structure development; GO:0006928 (0.40) ! movement of cell or subcellular component; GO:0019538 (0.36) ! protein metabolic process; GO:0006464 (0.35) ! cellular protein modification process; GO:0009653 (0.34) ! anatomical structure morphogenesis; GO:0007411 (0.32) ! axon guidance GO:0005634 (0.96) ! nucleus GO:0005634 ! nucleus 2 35121579-35130732 (17q12) High: testis (elongated or late spermatids);Medium: testis (round or early spermatids);Low: testis (Leydig cells; pachytene spermatocytes; preleptotene spermatocytes; sertoli cells; spermatogonia); Testis: 172.80; Cervix - Ectocervix: 0.37; Fallopian Tube: 0.36; Cells - Transformed fibroblasts: 0.34; Cells - EBV-transformed lymphocytes: 0.30; Brain - Cerebellum: 0.25; Ovary: 0.23; Brain - Cerebellar Hemisphere: 0.21; Cervix - Endocervix: 0.17; Skin - Not Sun Exposed (Suprapubic): 0.17; Skin - Sun Exposed (Lower leg): 0.17; Spleen: 0.14; Brain - Frontal Cortex (BA9): 0.14; Brain - Cortex: 0.14; Adipose - Subcutaneous: 0.14; Prostate: 0.12; Nerve - Tibial: 0.12; Thyroid: 0.12; Esophagus - Mucosa: 0.11; Breast - Mammary Tissue: 0.11; MASEALHQVGDGEEAVLKKENFNMMNALDQLPKPFSNPKSMNRTVTTKGLPLASKGNLVNFLEDDTINLLKPLPVEDSDCSSDETSISAFSSTLLNPIKLAVTQPNSSFFAGMLEGELNKLSFSPMAKNAENEDLALGPCPCPSKSQMATRGLLDLDNPELETETSSTHSESSVVVDLPDTPFIFEHTVNNSTAVISWTYALGKQPVSFYQLLLQEVAKTQENELPEAKNRPWIFNKILGTTVKLMELKPNTCYCLSVRAANTAGVGKWCKPYKFATLATDFSSFPENYPIQITVRRKEPRQKIVSIGPEEMRRLEDLEYLFPC C17orf50 Uncharacterized protein C17orf50 CQ050_HUMAN (Q8WW18-1) GO:0043657 (0.90) ! host cell; GO:0070062 (0.77) ! extracellular exosome; GO:0005829 (0.77) ! cytosol; GO:0005634 (0.77) ! nucleus; GO:0044428 (0.56) ! nuclear part; GO:0072372 (0.37) ! primary cilium; GO:0034399 (0.37) ! nuclear periphery; GO:0031965 (0.37) ! nuclear membrane; GO:0015630 (0.37) ! microtubule cytoskeleton; GO:0005739 (0.37) ! mitochondrion; GO:0005694 (0.37) ! chromosome; GO:0000775 (0.37) ! chromosome, centromeric region; GO:0000159 (0.37) ! protein phosphatase type 2A complex 1 35760897-35765079 (17q12) Testis: 203.00; Brain - Nucleus accumbens (basal ganglia): 1.74; Brain - Caudate (basal ganglia): 1.10; Brain - Cerebellar Hemisphere: 1.07; Brain - Cerebellum: 1.04; Brain - Putamen (basal ganglia): 0.88; Brain - Hypothalamus: 0.82; Brain - Frontal Cortex (BA9): 0.77; Brain - Cortex: 0.72; Brain - Anterior cingulate cortex (BA24): 0.65; Pituitary: 0.64; Nerve - Tibial: 0.58; Thyroid: 0.57; Brain - Amygdala: 0.51; Brain - Hippocampus: 0.46; Brain - Substantia nigra: 0.41; Bladder: 0.37; Fallopian Tube: 0.30; Colon - Transverse: 0.27; Skin - Not Sun Exposed (Suprapubic): 0.26; MDKHGVKTPLWKKETEELRAEDAEQEEGKEGSEDEDEDNQRPLEDSATEGEEPPRVAEEGEGRERRSVSYCPLRQESSTQQVALLRRADSGFWGWLGPLALLGGLTAPTDRKRSLPEEPCVLEIRRRPPRRGGCACCELLFCKKCRSLHSHPAYVAHCVLDHPDLGKAGAAGNS C17orf98 Uncharacterized protein C17orf98 CQ098_HUMAN (A8MV24-1) GO:0015926 (0.48) ! glucosidase activity GO:0051275 (0.37) ! beta-glucan catabolic process; GO:0030243 (0.37) ! cellulose metabolic process GO:0005576 (0.75) ! extracellular region 1 38835088-38841455 (17q12) Testis: 39.71; Cells - EBV-transformed lymphocytes: 0.12; Adrenal Gland: 0.10; Adipose - Visceral (Omentum): 0.09; Thyroid: 0.09; Prostate: 0.09; Ovary: 0.09; Pituitary: 0.09; Breast - Mammary Tissue: 0.08; Adipose - Subcutaneous: 0.07; MAYLSECRLRLEKGFILDGVAVSTAARAYGRSRPKLWSAIPPYNAQQDYHARSYFQSHVVPPLLRKTDQDHGGTGRDGWIVDYIHIFGQGQRYLNRRNWAGTGHSLQQVTGHDHYNADLKPIDGFNGRFGYRRNTPALRQSTSVFGEVTHFPLF HSPB9 Heat shock protein beta-9 HSPB9_HUMAN (Q9BQS6-1) GO:0042802 (0.76) ! identical protein binding; GO:0042803 (0.63) ! protein homodimerization activity; GO:0051082 (0.52) ! unfolded protein binding; GO:0005212 (0.50) ! structural constituent of eye lens; GO:0032182 (0.39) ! ubiquitin-like protein binding; GO:0030291 (0.39) ! protein serine/threonine kinase inhibitor activity; GO:0019900 (0.39) ! kinase binding; GO:0003723 (0.37) ! RNA binding; GO:0043169 (0.35) ! cation binding GO:0050896 (0.82) ! response to stimulus; GO:0006950 (0.80) ! response to stress; GO:0009628 (0.71) ! response to abiotic stimulus; GO:0042221 (0.60) ! response to chemical; GO:0009408 (0.60) ! response to heat; GO:0042981 (0.51) ! regulation of apoptotic process; GO:0006457 (0.51) ! protein folding; GO:0043066 (0.50) ! negative regulation of apoptotic process; GO:0022607 (0.49) ! cellular component assembly; GO:1901700 (0.48) ! response to oxygen-containing compound; GO:0048856 (0.48) ! anatomical structure development; GO:0010035 (0.48) ! response to inorganic substance; GO:0010033 (0.48) ! response to organic substance; GO:0006979 (0.48) ! response to oxidative stress; GO:0000302 (0.47) ! response to reactive oxygen species; GO:0032268 (0.46) ! regulation of cellular protein metabolic process; GO:0006461 (0.46) ! protein complex assembly; GO:0032879 (0.44) ! regulation of localization; GO:0031324 (0.43) ! negative regulation of cellular metabolic process; GO:0010468 (0.43) ! regulation of gene expression; GO:0043086 (0.42) ! negative regulation of catalytic activity; GO:0032269 (0.42) ! negative regulation of cellular protein metabolic process; GO:0031326 (0.42) ! regulation of cellular biosynthetic process; GO:0010556 (0.42) ! regulation of macromolecule biosynthetic process; GO:0009314 (0.42) ! response to radiation; GO:0080135 (0.41) ! regulation of cellular response to stress; GO:0051247 (0.41) ! positive regulation of protein metabolic process; GO:0042325 (0.41) ! regulation of phosphorylation; GO:0031399 (0.41) ! regulation of protein modification process; GO:0031325 (0.41) ! positive regulation of cellular metabolic process; GO:0007010 (0.41) ! cytoskeleton organization; GO:2000112 (0.40) ! regulation of cellular macromolecule biosynthetic process; GO:0065008 (0.40) ! regulation of biological quality; GO:0051704 (0.40) ! multi-organism process; GO:0051171 (0.40) ! regulation of nitrogen compound metabolic process; GO:0035966 (0.40) ! response to topologically incorrect protein; GO:0009605 (0.40) ! response to external stimulus; GO:0001932 (0.40) ! regulation of protein phosphorylation; GO:1903202 (0.39) ! negative regulation of oxidative stress-induced cell death; GO:0051707 (0.39) ! response to other organism; GO:0051240 (0.39) ! positive regulation of multicellular organismal process; GO:0036293 (0.39) ! response to decreased oxygen levels; GO:0030036 (0.39) ! actin cytoskeleton organization; GO:0009416 (0.39) ! response to light stimulus; GO:0006417 (0.39) ! regulation of translation; GO:0001654 (0.39) ! eye development; GO:2001243 (0.38) ! negative regulation of intrinsic apoptotic signaling pathway; GO:2000117 (0.38) ! negative regulation of cysteine-type endopeptidase activity; GO:1902742 (0.38) ! apoptotic process involved in development; GO:1902175 (0.38) ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; GO:0051094 (0.38) ! positive regulation of developmental process; GO:0045859 (0.38) ! regulation of protein kinase activity; GO:0043623 (0.38) ! cellular protein complex assembly; GO:0043281 (0.38) ! regulation of cysteine-type endopeptidase activity involved in apoptotic process; GO:0043010 (0.38) ! camera-type eye development; GO:0042534 (0.38) ! regulation of tumor necrosis factor biosynthetic process; GO:0042108 (0.38) ! positive regulation of cytokine biosynthetic process; GO:0033673 (0.38) ! negative regulation of kinase activity; GO:0032760 (0.38) ! positive regulation of tumor necrosis factor production; GO:0032732 (0.38) ! positive regulation of interleukin-1 production; GO:0032651 (0.38) ! regulation of interleukin-1 beta production; GO:0001933 (0.38) ! negative regulation of protein phosphorylation; GO:0001558 (0.38) ! regulation of cell growth; GO:2001028 (0.37) ! positive regulation of endothelial cell chemotaxis; GO:1904018 (0.37) ! positive regulation of vasculature development; GO:0048010 (0.37) ! vascular endothelial growth factor receptor signaling pathway; GO:0045765 (0.37) ! regulation of angiogenesis; GO:0043535 (0.37) ! regulation of blood vessel endothelial cell migration; GO:0038089 (0.37) ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway; GO:0034109 (0.37) ! homotypic cell-cell adhesion; GO:0016032 (0.37) ! viral process; GO:0009653 (0.37) ! anatomical structure morphogenesis; GO:0048048 (0.36) ! embryonic eye morphogenesis; GO:0045927 (0.36) ! positive regulation of growth; GO:0044057 (0.36) ! regulation of system process; GO:0042327 (0.36) ! positive regulation of phosphorylation; GO:0031401 (0.36) ! positive regulation of protein modification process; GO:0009411 (0.36) ! response to UV; GO:0002089 (0.36) ! lens morphogenesis in camera-type eye; GO:0000904 (0.36) ! cell morphogenesis involved in differentiation; GO:0090257 (0.35) ! regulation of muscle system process; GO:0071900 (0.35) ! regulation of protein serine/threonine kinase activity; GO:0070307 (0.35) ! lens fiber cell development; GO:0043487 (0.35) ! regulation of RNA stability; GO:0031076 (0.35) ! embryonic camera-type eye development; GO:0001894 (0.35) ! tissue homeostasis; GO:0030168 (0.34) ! platelet activation; GO:0007249 (0.34) ! I-kappaB kinase/NF-kappaB signaling; GO:0006914 (0.34) ! autophagy; GO:0006413 (0.34) ! translational initiation; GO:0044707 (0.33) ! single-multicellular organism process; GO:0019538 (0.33) ! protein metabolic process; GO:0006937 (0.31) ! regulation of muscle contraction GO:0005634 (0.97) ! nucleus GO:0005737 ! cytoplasm; GO:0005634 ! nucleus; GO:0005515 ! protein binding 3 GO:0005515 ! protein binding 42121431-42123352 (17q21.2) Testis: 94.63; Liver: 5.04; Pancreas: 2.31; Pituitary: 2.14; Ovary: 2.10; Prostate: 1.32; Fallopian Tube: 1.08; Colon - Sigmoid: 1.07; Spleen: 1.07; Uterus: 1.03; Bladder: 0.98; Brain - Nucleus accumbens (basal ganglia): 0.92; Esophagus - Gastroesophageal Junction: 0.90; Brain - Cerebellar Hemisphere: 0.88; Brain - Cerebellum: 0.85; Esophagus - Muscularis: 0.85; Stomach: 0.82; Cervix - Endocervix: 0.78; Kidney - Cortex: 0.76; Vagina: 0.73; MQRVGNTFSNESRVASRCPSVGLAERNRVATMPVRLLRDSPAAQEDNDHARDGFQMKLDAHGFAPEELVVQVDGQWLMVTGQQQLDVRDPERVSYRMSQKVHRKMLPSNLSPTAMTCCLTPSGQLWVRGQCVALALPEAQTGPSPRLGSLGSKASNLTR TMEM106A Transmembrane protein 106A T106A_HUMAN (Q96A25-1) GO:0008236 (0.36) ! serine-type peptidase activity; GO:0004175 (0.36) ! endopeptidase activity GO:0048813 (1.00) ! dendrite morphogenesis; GO:0032418 (1.00) ! lysosome localization; GO:0007041 (0.93) ! lysosomal transport; GO:0007040 (0.93) ! lysosome organization GO:0016020 ! membrane GO:0016021 ! integral component of membrane 2 43211835-43220041 (17q21.31) Cells - EBV-transformed lymphocytes: 15.57; Spleen: 14.54; Cervix - Endocervix: 9.18; Ovary: 8.45; Lung: 8.28; Cervix - Ectocervix: 8.23; Thyroid: 8.00; Kidney - Cortex: 7.20; Testis: 7.16; Uterus: 7.11; Artery - Aorta: 6.58; Nerve - Tibial: 6.52; Fallopian Tube: 6.50; Adipose - Subcutaneous: 6.14; Artery - Coronary: 6.06; Adipose - Visceral (Omentum): 5.77; Breast - Mammary Tissue: 5.08; Small Intestine - Terminal Ileum: 4.79; Prostate: 4.74; Cells - Transformed fibroblasts: 4.29; MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQSYEYVDCRGNASVPHQLTPHPP C17orf105 Uncharacterized protein C17orf105 CF97D_HUMAN (B2RV13-1) GO:0016740 (0.44) ! transferase activity; GO:0004842 (0.41) ! ubiquitin-protein transferase activity; GO:0004185 (0.36) ! serine-type carboxypeptidase activity; GO:0004181 (0.36) ! metallocarboxypeptidase activity GO:0019538 (0.94) ! protein metabolic process; GO:0034641 (0.53) ! cellular nitrogen compound metabolic process; GO:0006464 (0.51) ! cellular protein modification process; GO:0042787 (0.49) ! protein ubiquitination involved in ubiquitin-dependent protein catabolic process; GO:1901564 (0.47) ! organonitrogen compound metabolic process; GO:0043603 (0.47) ! cellular amide metabolic process; GO:0016485 (0.44) ! protein processing; GO:0006518 (0.44) ! peptide metabolic process GO:0005634 (0.81) ! nucleus; GO:0005829 (0.76) ! cytosol; GO:0044428 (0.54) ! nuclear part; GO:0005654 (0.51) ! nucleoplasm; GO:0044421 (0.48) ! extracellular region part; GO:0044454 (0.45) ! nuclear chromosome part; GO:0005615 (0.44) ! extracellular space; GO:0000790 (0.41) ! nuclear chromatin 2 43780435-43787612 (17q21.31) High: testis (cells in seminiferous ducts); Testis: 36.54; Brain - Cerebellar Hemisphere: 0.30; Brain - Cerebellum: 0.28; Spleen: 0.12; Brain - Frontal Cortex (BA9): 0.09; Brain - Cortex: 0.08; Nerve - Tibial: 0.06; Artery - Coronary: 0.06; Artery - Aorta: 0.06; Pituitary: 0.06; Brain - Hypothalamus: 0.06; Brain - Anterior cingulate cortex (BA24): 0.05; Skin - Sun Exposed (Lower leg): 0.05; Cervix - Ectocervix: 0.05; Brain - Nucleus accumbens (basal ganglia): 0.05; Brain - Spinal cord (cervical c-1): 0.05; Adipose - Subcutaneous: 0.05; Brain - Substantia nigra: 0.05; Brain - Amygdala: 0.05; Lung: 0.04; MNNSLDYLAYPVIVSNHRQSTTFRKKLDFGHYVSHKNRIQIAKPTVDTKPPVAHTNHILKLSKLQGEQKKINKIEYENKQLCQKIANAHRGPAKVDCWNEYFSKSLNRETRNRELVRITMENQGILKRLVDRKPHYDRRASEIDWQNSRRYIRNTTRYLLSQNE LSM12 Protein LSM12 homolog LSM12_HUMAN (Q3MHD2-1) GO:0003723 (0.59) ! RNA binding GO:0090304 (0.79) ! nucleic acid metabolic process; GO:0016070 (0.73) ! RNA metabolic process; GO:0022618 (0.39) ! ribonucleoprotein complex assembly; GO:0000387 (0.32) ! spliceosomal snRNP assembly GO:0005576 (0.55) ! extracellular region; GO:0005829 (0.47) ! cytosol; GO:0005634 (0.33) ! nucleus; GO:0036464 (0.31) ! cytoplasmic ribonucleoprotein granule 3 44034635-44067619 (17q21.31) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in tubules);testis (cells in seminiferous ducts);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);breast (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);thyroid gland (glandular cells);cerebral cortex (neuronal cells);lymph node (germinal center cells; non-germinal center cells);bronchus (respiratory epithelial cells);skeletal muscle (myocytes);urinary bladder (urothelial cells);small intestine (glandular cells);liver (hepatocytes); Cells - EBV-transformed lymphocytes: 16.88; Cells - Transformed fibroblasts: 16.69; Testis: 13.62; Esophagus - Mucosa: 7.91; Uterus: 7.03; Lung: 6.80; Fallopian Tube: 6.73; Vagina: 6.67; Bladder: 6.56; Cervix - Ectocervix: 6.50; Cervix - Endocervix: 6.42; Brain - Cerebellar Hemisphere: 6.34; Adipose - Visceral (Omentum): 6.34; Thyroid: 6.29; Adrenal Gland: 6.21; Breast - Mammary Tissue: 6.11; Ovary: 5.97; Adipose - Subcutaneous: 5.96; Esophagus - Muscularis: 5.96; Prostate: 5.93; MAAPPGEYFSVGSQVSCRTCQEQRLQGEVVAFDYQSKMLALKCPSSSGKPNHADILLINLQYVSEVEIINDRTETPPPLASLNVSKLASKARTEKEEKLSQAYAISAGVSLEGQQLFQTIHKTIKDCKWQEKNIVVMEEVVITPPYQVENCKGKEGSALSHVRKIVEKHFRDVESQKILQRSQAQQPQKEAALSS C17orf53 Uncharacterized protein C17orf53 CQ053_HUMAN (Q8N3J3-1) GO:0016787 (0.43) ! hydrolase activity; GO:0004175 (0.37) ! endopeptidase activity; GO:0004252 (0.36) ! serine-type endopeptidase activity GO:0051179 (0.58) ! localization; GO:0065008 (0.57) ! regulation of biological quality; GO:0006810 (0.57) ! transport; GO:0048583 (0.54) ! regulation of response to stimulus; GO:1902578 (0.53) ! single-organism localization; GO:0048584 (0.52) ! positive regulation of response to stimulus; GO:0044765 (0.52) ! single-organism transport; GO:0016192 (0.52) ! vesicle-mediated transport; GO:0051240 (0.51) ! positive regulation of multicellular organismal process; GO:0042127 (0.51) ! regulation of cell proliferation; GO:0080134 (0.50) ! regulation of response to stress; GO:0032101 (0.50) ! regulation of response to external stimulus; GO:0030198 (0.50) ! extracellular matrix organization; GO:0022411 (0.50) ! cellular component disassembly; GO:0022407 (0.50) ! regulation of cell-cell adhesion; GO:0010810 (0.50) ! regulation of cell-substrate adhesion; GO:0007162 (0.50) ! negative regulation of cell adhesion; GO:0006887 (0.50) ! exocytosis; GO:2000047 (0.49) ! regulation of cell-cell adhesion mediated by cadherin; GO:0045055 (0.49) ! regulated exocytosis; GO:0032103 (0.49) ! positive regulation of response to external stimulus; GO:0030194 (0.49) ! positive regulation of blood coagulation; GO:0022408 (0.49) ! negative regulation of cell-cell adhesion; GO:0019538 (0.45) ! protein metabolic process; GO:0006508 (0.37) ! proteolysis; GO:0048585 (0.31) ! negative regulation of response to stimulus GO:0005576 (0.91) ! extracellular region; GO:0044421 (0.70) ! extracellular region part; GO:0005615 (0.67) ! extracellular space; GO:0031982 (0.55) ! vesicle; GO:0031988 (0.54) ! membrane-bounded vesicle; GO:0070062 (0.53) ! extracellular exosome; GO:0005886 (0.36) ! plasma membrane 2 44141906-44162476 (17q21.31) Testis: 29.93; Cells - EBV-transformed lymphocytes: 14.84; Esophagus - Mucosa: 3.92; Skin - Sun Exposed (Lower leg): 3.21; Esophagus - Muscularis: 3.14; Cells - Transformed fibroblasts: 2.75; Adipose - Subcutaneous: 2.71; Skin - Not Sun Exposed (Suprapubic): 2.66; Breast - Mammary Tissue: 2.61; Spleen: 2.40; Nerve - Tibial: 2.33; Vagina: 2.31; Adipose - Visceral (Omentum): 1.98; Ovary: 1.85; Cervix - Endocervix: 1.76; Cervix - Ectocervix: 1.74; Uterus: 1.62; Brain - Cerebellum: 1.57; Fallopian Tube: 1.57; Brain - Cerebellar Hemisphere: 1.54; MACSLQKLFAVEEEFEDEDFLSAVEDAENRFTGSLPVNAGRLRPVSSRPQETVQAQSSRLLLLHPTAPSEALGLPDLDLCLPASSTPSADSRPSCIGAAPLRPVSTSSSWIGNQRRVTVTEVLRETARPQSSALHPLLTFESQQQQVGGFEGPEQDEFDKVLASMELEEPGMELECGVSSEAIPILPAQQREGSVLAKKARVVDLSGSCQKGPVPAIHKAGIMSAQDESLDPVIQCRTPRPPLRPGAVGHLPVPTALTVPTQQLHWEVCPQRSPVQALQPLQAARGTIQSSPQNRFPCQPFQSPSSWLSGKAHLPRPRTPNSSCSTPSRTSSGLFPRIPLQPQAPVSSIGSPVGTPKGPQGALQTPIVTNHLVQLVTAASRTPQQPTHPSTRAKTRRFPGPAGILPHQQSGRSLEDIMVSAPQTPTHGALAKFQTEIVASSQASVEEDFGRGPWLTMKSTLGLDERDPSCFLCTYSIVMVLRKQAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMQGTVHRLLLETCQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSPDSGDGSFLKPSQPFPKDSGSFQHDVAAKPEEGFRTAQNLEAEASPEEELPEADDLDGLLSELPEDFFCGTSS TMUB2 Transmembrane and ubiquitin-like domain-containing protein 2 TMUB2_HUMAN (Q71RG4-1) GO:1990841 (0.41) ! promoter-specific chromatin binding; GO:0051718 (0.41) ! DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; GO:0045322 (0.41) ! unmethylated CpG binding; GO:0042826 (0.41) ! histone deacetylase binding; GO:0030331 (0.41) ! estrogen receptor binding; GO:0019904 (0.41) ! protein domain specific binding; GO:0008327 (0.41) ! methyl-CpG binding; GO:0008270 (0.41) ! zinc ion binding; GO:0003723 (0.41) ! RNA binding; GO:0003690 (0.41) ! double-stranded DNA binding GO:0019538 (0.78) ! protein metabolic process; GO:0019941 (0.63) ! modification-dependent protein catabolic process; GO:0006511 (0.62) ! ubiquitin-dependent protein catabolic process; GO:0043412 (0.56) ! macromolecule modification; GO:0071840 (0.54) ! cellular component organization or biogenesis; GO:0034641 (0.48) ! cellular nitrogen compound metabolic process; GO:0090304 (0.47) ! nucleic acid metabolic process; GO:0051246 (0.47) ! regulation of protein metabolic process; GO:0050896 (0.47) ! response to stimulus; GO:0043161 (0.47) ! proteasome-mediated ubiquitin-dependent protein catabolic process; GO:0032268 (0.46) ! regulation of cellular protein metabolic process; GO:0006259 (0.46) ! DNA metabolic process; GO:0051716 (0.44) ! cellular response to stimulus; GO:0043933 (0.44) ! macromolecular complex subunit organization; GO:0030433 (0.44) ! ER-associated ubiquitin-dependent protein catabolic process; GO:0006950 (0.44) ! response to stress; GO:0010605 (0.42) ! negative regulation of macromolecule metabolic process; GO:0090116 (0.41) ! C-5 methylation of cytosine; GO:0031324 (0.41) ! negative regulation of cellular metabolic process; GO:0016568 (0.41) ! chromatin modification; GO:0051247 (0.40) ! positive regulation of protein metabolic process; GO:0048856 (0.40) ! anatomical structure development; GO:0032269 (0.40) ! negative regulation of cellular protein metabolic process; GO:0032270 (0.38) ! positive regulation of cellular protein metabolic process; GO:0031399 (0.38) ! regulation of protein modification process; GO:0048513 (0.37) ! animal organ development; GO:0042221 (0.37) ! response to chemical; GO:1901538 (0.36) ! changes to DNA methylation involved in embryo development; GO:0031401 (0.36) ! positive regulation of protein modification process; GO:0031400 (0.36) ! negative regulation of protein modification process; GO:0010033 (0.36) ! response to organic substance; GO:0007420 (0.36) ! brain development; GO:1901564 (0.35) ! organonitrogen compound metabolic process; GO:0070887 (0.35) ! cellular response to chemical stimulus; GO:0010468 (0.35) ! regulation of gene expression; GO:0009628 (0.35) ! response to abiotic stimulus; GO:0071310 (0.34) ! cellular response to organic substance; GO:0045935 (0.34) ! positive regulation of nucleobase-containing compound metabolic process; GO:0030154 (0.34) ! cell differentiation; GO:0010639 (0.34) ! negative regulation of organelle organization; GO:0010628 (0.34) ! positive regulation of gene expression; GO:0009719 (0.34) ! response to endogenous stimulus; GO:0000122 (0.34) ! negative regulation of transcription from RNA polymerase II promoter; GO:0045471 (0.33) ! response to ethanol; GO:0043207 (0.33) ! response to external biotic stimulus; GO:0042127 (0.33) ! regulation of cell proliferation; GO:0014070 (0.33) ! response to organic cyclic compound; GO:0009408 (0.33) ! response to heat; GO:0009314 (0.33) ! response to radiation; GO:0001101 (0.33) ! response to acid chemical; GO:1990090 (0.32) ! cellular response to nerve growth factor stimulus; GO:0090309 (0.32) ! positive regulation of methylation-dependent chromatin silencing; GO:0071560 (0.32) ! cellular response to transforming growth factor beta stimulus; GO:0071284 (0.32) ! cellular response to lead ion; GO:0071230 (0.32) ! cellular response to amino acid stimulus; GO:0051573 (0.32) ! negative regulation of histone H3-K9 methylation; GO:0051571 (0.32) ! positive regulation of histone H3-K4 methylation; GO:0046500 (0.32) ! S-adenosylmethionine metabolic process; GO:0046499 (0.32) ! S-adenosylmethioninamine metabolic process; GO:0046498 (0.32) ! S-adenosylhomocysteine metabolic process; GO:0044026 (0.32) ! DNA hypermethylation; GO:0036276 (0.32) ! response to antidepressant; GO:0036120 (0.32) ! cellular response to platelet-derived growth factor stimulus; GO:0033574 (0.32) ! response to testosterone; GO:0033189 (0.32) ! response to vitamin A; GO:0032496 (0.32) ! response to lipopolysaccharide; GO:0032355 (0.32) ! response to estradiol; GO:0031000 (0.32) ! response to caffeine; GO:0030182 (0.32) ! neuron differentiation; GO:0014823 (0.32) ! response to activity; GO:0010424 (0.32) ! DNA methylation on cytosine within a CG sequence; GO:0010216 (0.32) ! maintenance of DNA methylation; GO:0010212 (0.32) ! response to ionizing radiation; GO:0009636 (0.32) ! response to toxic substance; GO:0007568 (0.32) ! aging; GO:0007265 (0.32) ! Ras protein signal transduction GO:0005634 (1.00) ! nucleus; GO:0044428 (0.89) ! nuclear part; GO:0005654 (0.79) ! nucleoplasm; GO:0043234 (0.64) ! protein complex; GO:0044427 (0.44) ! chromosomal part; GO:0043025 (0.44) ! neuronal cell body; GO:0005721 (0.43) ! pericentric heterochromatin; GO:0005657 (0.43) ! replication fork GO:0005515 ! protein binding GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 GO:0005515 ! protein binding 44186970-44191731 (17q21.31) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (neuronal cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);heart muscle (myocytes);duodenum (glandular cells);bronchus (respiratory epithelial cells);parathyroid gland (glandular cells);skeletal muscle (myocytes);appendix (glandular cells);liver (hepatocytes);rectum (glandular cells); Testis: 66.97; Spleen: 65.14; Thyroid: 64.86; Cervix - Endocervix: 60.76; Prostate: 53.27; Brain - Cerebellum: 52.39; Brain - Cerebellar Hemisphere: 51.70; Uterus: 49.60; Nerve - Tibial: 47.60; Bladder: 47.01; Fallopian Tube: 46.91; Artery - Tibial: 46.59; Ovary: 46.54; Whole Blood: 46.43; Cervix - Ectocervix: 44.28; Lung: 44.10; Artery - Aorta: 43.17; Artery - Coronary: 43.08; Vagina: 42.80; Breast - Mammary Tissue: 41.12; MISRHLQNNLMSVDPASSQAMELSDVTLIEGVGNEVMVVAGVVVLILALVLAWLSTYVADSGSNQLLGAIVSAGDTSVLHLGHVDHLVAGQGNPEPTELPHPSEGNDEKAEEAGEGRGDSTGEAGAGGGVEPSLEHLLDIQGLPKRQAGAGSSSPEAPLRSEDSTCLPPSPGLITVRLKFLNDTEELAVARPEDTVGALKSKYFPGQESQMKLIYQGRLLQDPARTLRSLNITDNCVIHCHRSPPGSAVPGPSASLAPSATEPPSLGVNVGSLMVPVFVVLLGVVWYFRINYRQFFTAPATVSLVGVTVFFSFLVFGMYGR FAM171A2 FAM171A2 F1712_HUMAN (A8MVW0-1) GO:1901363 (0.58) ! heterocyclic compound binding; GO:0097159 (0.58) ! organic cyclic compound binding; GO:0003676 (0.56) ! nucleic acid binding; GO:0019899 (0.54) ! enzyme binding; GO:0017016 (0.52) ! Ras GTPase binding; GO:0022892 (0.47) ! substrate-specific transporter activity GO:0051179 (0.49) ! localization; GO:0006810 (0.46) ! transport; GO:0019538 (0.40) ! protein metabolic process; GO:0051171 (0.39) ! regulation of nitrogen compound metabolic process; GO:0050896 (0.39) ! response to stimulus; GO:0032879 (0.39) ! regulation of localization; GO:0016192 (0.39) ! vesicle-mediated transport; GO:0010468 (0.39) ! regulation of gene expression; GO:0051641 (0.38) ! cellular localization; GO:0051049 (0.38) ! regulation of transport; GO:0048193 (0.38) ! Golgi vesicle transport; GO:0008104 (0.38) ! protein localization; GO:0006355 (0.38) ! regulation of transcription, DNA-templated; GO:0071702 (0.35) ! organic substance transport; GO:0051246 (0.35) ! regulation of protein metabolic process; GO:0046907 (0.35) ! intracellular transport; GO:0034613 (0.35) ! cellular protein localization; GO:0031324 (0.35) ! negative regulation of cellular metabolic process; GO:0022402 (0.35) ! cell cycle process; GO:0010605 (0.35) ! negative regulation of macromolecule metabolic process; GO:0006357 (0.35) ! regulation of transcription from RNA polymerase II promoter; GO:0045892 (0.34) ! negative regulation of transcription, DNA-templated; GO:0042221 (0.34) ! response to chemical; GO:1901575 (0.33) ! organic substance catabolic process; GO:0051493 (0.33) ! regulation of cytoskeleton organization; GO:0033365 (0.33) ! protein localization to organelle; GO:0032886 (0.33) ! regulation of microtubule-based process; GO:0032880 (0.33) ! regulation of protein localization; GO:0070507 (0.32) ! regulation of microtubule cytoskeleton organization; GO:0060341 (0.32) ! regulation of cellular localization; GO:0051726 (0.32) ! regulation of cell cycle; GO:0051223 (0.32) ! regulation of protein transport; GO:0009057 (0.32) ! macromolecule catabolic process; GO:0051298 (0.31) ! centrosome duplication; GO:0050658 (0.31) ! RNA transport; GO:0046822 (0.31) ! regulation of nucleocytoplasmic transport; GO:0046605 (0.31) ! regulation of centrosome cycle; GO:0033157 (0.31) ! regulation of intracellular protein transport; GO:0030163 (0.31) ! protein catabolic process; GO:0009894 (0.31) ! regulation of catabolic process; GO:0000054 (0.31) ! ribosomal subunit export from nucleus GO:0043234 (0.64) ! protein complex; GO:0031982 (0.53) ! vesicle; GO:0031988 (0.52) ! membrane-bounded vesicle; GO:0044421 (0.51) ! extracellular region part; GO:0070062 (0.48) ! extracellular exosome; GO:0005634 (0.48) ! nucleus; GO:0044428 (0.40) ! nuclear part; GO:0005829 (0.35) ! cytosol; GO:0031090 (0.34) ! organelle membrane GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 44353215-44363875 (17q21.31) Brain - Cerebellar Hemisphere: 35.12; Brain - Cerebellum: 35.00; Brain - Frontal Cortex (BA9): 25.35; Brain - Cortex: 24.67; Brain - Anterior cingulate cortex (BA24): 16.97; Pituitary: 16.93; Brain - Nucleus accumbens (basal ganglia): 14.72; Cervix - Endocervix: 11.60; Brain - Hypothalamus: 11.41; Brain - Caudate (basal ganglia): 10.03; Brain - Amygdala: 9.89; Brain - Hippocampus: 8.84; Brain - Putamen (basal ganglia): 7.61; Ovary: 7.54; Uterus: 6.81; Cervix - Ectocervix: 6.51; Vagina: 3.94; Thyroid: 3.59; Brain - Substantia nigra: 3.51; Esophagus - Mucosa: 3.14; MPPASGPSVLARLLPLLGLLLGSASRAPGKSPPEPPSPQEILIKVQVYVSGELVPLARASVDVFGNRTLLAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLPLYASVSLYLLPERPATLILYEDLVHILLGSPGARSQPLVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEASSSGNGSWLELMPLTAVSVHLLTGNGTEVPLSGPIHLSLPVPSETRALTVGTSIPAWRFDPKSGLWVRNGTGVIRKEGRQLYWTFVSPQLGYWVAAMASPTAGLVTITSGIQDIGTYHTIFLLTILAALALLVLILLCLLIYYCRRRCLKPRQQHRKLQLSGPSDGNKRDQATSMSQLHLICGGPLEPAPSGDPEAPPPGPLHSAFSSSRDLASSRDDFFRTKPRSASRPAAEPSGARGGESAGLKGARSAEGPGGLEPGLEEHRRGPSGAAAFLHEPPSPPPPFDHYLGHKGAAEGKTPDFLLSQSVDQLARPPSLGQAGQLIFCGSIDHLKDNVYRNVMPTLVIPAHYVRLGGEAGAAGVGDEPAPPEGTAPGPARAFPQPDPQRPQMPGHSGPGGEGGGGGGEGWGAGRAAPVSGSVTIPVLFNESTMAQLNGELQALTEKKLLELGVKPHPRAWFVSLDGRSNSQVRHSYIDLQAGGGARSTDASLDSGVDVHEARPARRRPAREERERAPPAAPPPPPAPPRLALSEDTEPSSSESRTGLCSPEDNSLTPLLDEVAAPEGRAATVPRGRGRSRGDSSRSSASELRRDSLTSPEDELGAEVGDEAGDKKSPWQRREERPLMVFNVK CCDC43 Coiled-coil domain-containing protein 43 CCD43_HUMAN (Q96MW1-1) GO:0006810 (0.44) ! transport; GO:0046907 (0.41) ! intracellular transport; GO:0006886 (0.38) ! intracellular protein transport; GO:0006606 (0.35) ! protein import into nucleus; GO:0006607 (0.32) ! NLS-bearing protein import into nucleus GO:0005829 (0.70) ! cytosol; GO:0044428 (0.66) ! nuclear part; GO:0005654 (0.51) ! nucleoplasm; GO:0043234 (0.43) ! protein complex; GO:0043228 (0.37) ! non-membrane-bounded organelle; GO:0031090 (0.37) ! organelle membrane; GO:0005643 (0.35) ! nuclear pore; GO:0044463 (0.33) ! cell projection part; GO:0030054 (0.31) ! cell junction GO:0005829 ! cytosol; GO:0005515 ! protein binding 3 GO:0005515 ! protein binding 44673069-44689779 (17q21.31) Medium: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (glandular cells);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (neuronal cells);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);duodenum (glandular cells);cerebral cortex (neuronal cells; neuropil);vagina (squamous epithelial cells);lymph node (germinal center cells; non-germinal center cells); Muscle - Skeletal: 27.17; Cells - Transformed fibroblasts: 26.08; Cells - EBV-transformed lymphocytes: 26.07; Brain - Cerebellar Hemisphere: 24.00; Brain - Cerebellum: 18.54; Nerve - Tibial: 18.03; Brain - Spinal cord (cervical c-1): 17.89; Brain - Frontal Cortex (BA9): 15.66; Thyroid: 14.89; Uterus: 14.86; Fallopian Tube: 14.42; Cervix - Ectocervix: 14.17; Vagina: 14.12; Esophagus - Mucosa: 14.08; Cervix - Endocervix: 13.91; Lung: 13.67; Prostate: 13.16; Artery - Coronary: 13.11; Breast - Mammary Tissue: 13.10; Testis: 12.93; MAAPSEVAAIAPGEGDGGGGGFGSWLDGRLEALGVDRAVYGAYILGILQEEEEEEKLDALQGILSAFLEEDSLLNICKEIVERWSETQNVVTKVKKEDEVQAIATLIEKQAQIVVKPRMVSEEEKQRKAALLAQYADVTDEEDEADEKDDSGATTMNIGSDKLLFRNTNVEDVLNARKLERDSLRDESQRKKEQDKLQRERDKLAKQERKEKEKKRTQRGERKR HIGD1B HIG1 domain family member 1B HIG1B_HUMAN (Q9P298-1) GO:0016740 (0.79) ! transferase activity; GO:0061630 (0.71) ! ubiquitin protein ligase activity GO:0043066 (0.32) ! negative regulation of apoptotic process; GO:0043623 (0.31) ! cellular protein complex assembly GO:0043234 (0.88) ! protein complex; GO:0005634 (0.71) ! nucleus; GO:0044429 (0.53) ! mitochondrial part; GO:0044428 (0.45) ! nuclear part; GO:0044427 (0.45) ! chromosomal part; GO:0005739 (0.42) ! mitochondrion; GO:0097249 (0.32) ! mitochondrial respiratory chain supercomplex; GO:0031305 (0.32) ! integral component of mitochondrial inner membrane GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 44846353-44850480 (17q21.31) Lung: 40.38; Brain - Substantia nigra: 21.38; Brain - Putamen (basal ganglia): 20.96; Brain - Caudate (basal ganglia): 19.61; Brain - Frontal Cortex (BA9): 17.02; Brain - Anterior cingulate cortex (BA24): 16.71; Brain - Hippocampus: 15.77; Brain - Cortex: 15.70; Brain - Hypothalamus: 15.58; Heart - Left Ventricle: 15.38; Brain - Amygdala: 15.24; Uterus: 14.89; Brain - Nucleus accumbens (basal ganglia): 13.81; Brain - Spinal cord (cervical c-1): 11.42; Prostate: 10.93; Adipose - Visceral (Omentum): 10.42; Brain - Cerebellum: 9.27; Brain - Cerebellar Hemisphere: 8.86; Esophagus - Muscularis: 8.42; Breast - Mammary Tissue: 8.37; MSANRRWWVPPDDEDCVSEKLLRKTRESPLVPIGLGGCLVVAAYRIYRLRSRGSTKMSIHLIHTRVAAQACAVGAIMLGAVYTMYSDYVKRMAQDAGEK FAM187A Ig-like V-type domain-containing protein FAM187A F187A_HUMAN (A6NFU0-1) GO:0004872 (0.55) ! receptor activity; GO:0042802 (0.50) ! identical protein binding; GO:0046983 (0.48) ! protein dimerization activity; GO:0004888 (0.46) ! transmembrane signaling receptor activity; GO:0097367 (0.42) ! carbohydrate derivative binding GO:0006928 (0.64) ! movement of cell or subcellular component; GO:0007411 (0.59) ! axon guidance; GO:0048856 (0.55) ! anatomical structure development; GO:0007155 (0.52) ! cell adhesion; GO:0048583 (0.50) ! regulation of response to stimulus; GO:0009653 (0.50) ! anatomical structure morphogenesis; GO:0098609 (0.49) ! cell-cell adhesion; GO:0051179 (0.49) ! localization; GO:0045595 (0.49) ! regulation of cell differentiation; GO:0050896 (0.47) ! response to stimulus; GO:0022603 (0.47) ! regulation of anatomical structure morphogenesis; GO:0010975 (0.47) ! regulation of neuron projection development; GO:0022604 (0.46) ! regulation of cell morphogenesis; GO:0050770 (0.45) ! regulation of axonogenesis; GO:0048584 (0.45) ! positive regulation of response to stimulus; GO:0048468 (0.45) ! cell development; GO:0016477 (0.45) ! cell migration; GO:0009966 (0.45) ! regulation of signal transduction; GO:0008037 (0.45) ! cell recognition; GO:0034613 (0.44) ! cellular protein localization; GO:0071205 (0.43) ! protein localization to juxtaparanode region of axon; GO:0006810 (0.43) ! transport; GO:0003008 (0.43) ! system process; GO:0048666 (0.42) ! neuron development; GO:0044707 (0.42) ! single-multicellular organism process; GO:0032268 (0.42) ! regulation of cellular protein metabolic process; GO:0030154 (0.42) ! cell differentiation; GO:0016337 (0.42) ! single organismal cell-cell adhesion; GO:0009967 (0.42) ! positive regulation of signal transduction; GO:0009893 (0.42) ! positive regulation of metabolic process; GO:0007010 (0.42) ! cytoskeleton organization; GO:0006897 (0.42) ! endocytosis; GO:0065008 (0.41) ! regulation of biological quality; GO:0051241 (0.41) ! negative regulation of multicellular organismal process; GO:0051093 (0.41) ! negative regulation of developmental process; GO:0042221 (0.41) ! response to chemical; GO:0032270 (0.41) ! positive regulation of cellular protein metabolic process; GO:0030030 (0.41) ! cell projection organization; GO:0050877 (0.40) ! neurological system process; GO:0050768 (0.40) ! negative regulation of neurogenesis; GO:0048589 (0.40) ! developmental growth; GO:0032989 (0.40) ! cellular component morphogenesis; GO:0010033 (0.40) ! response to organic substance; GO:0050773 (0.39) ! regulation of dendrite development; GO:0048812 (0.39) ! neuron projection morphogenesis; GO:0048675 (0.39) ! axon extension; GO:0044802 (0.39) ! single-organism membrane organization; GO:0043207 (0.39) ! response to external biotic stimulus; GO:0010628 (0.39) ! positive regulation of gene expression; GO:0009628 (0.39) ! response to abiotic stimulus; GO:0008038 (0.39) ! neuron recognition; GO:0007017 (0.39) ! microtubule-based process; GO:0001764 (0.39) ! neuron migration; GO:1904936 (0.38) ! interneuron migration; GO:1903319 (0.38) ! positive regulation of protein maturation; GO:1902284 (0.38) ! neuron projection extension involved in neuron projection guidance; GO:0098581 (0.38) ! detection of external biotic stimulus; GO:0090659 (0.38) ! walking behavior; GO:0070613 (0.38) ! regulation of protein processing; GO:0060167 (0.38) ! regulation of adenosine receptor signaling pathway; GO:0050974 (0.38) ! detection of mechanical stimulus involved in sensory perception; GO:0048708 (0.38) ! astrocyte differentiation; GO:0048167 (0.38) ! regulation of synaptic plasticity; GO:0045862 (0.38) ! positive regulation of proteolysis; GO:0045745 (0.38) ! positive regulation of G-protein coupled receptor protein signaling pathway; GO:0045685 (0.38) ! regulation of glial cell differentiation; GO:0045161 (0.38) ! neuronal ion channel clustering; GO:0043112 (0.38) ! receptor metabolic process; GO:0032536 (0.38) ! regulation of cell projection size; GO:0032291 (0.38) ! axon ensheathment in central nervous system; GO:0031589 (0.38) ! cell-substrate adhesion; GO:0021894 (0.38) ! cerebral cortex GABAergic interneuron development; GO:0021830 (0.38) ! interneuron migration from the subpallium to the cortex; GO:0014003 (0.38) ! oligodendrocyte development; GO:0009593 (0.38) ! detection of chemical stimulus; GO:0008344 (0.38) ! adult locomotory behavior; GO:0007611 (0.38) ! learning or memory; GO:0006898 (0.38) ! receptor-mediated endocytosis; GO:0002237 (0.38) ! response to molecule of bacterial origin; GO:0048731 (0.36) ! system development; GO:0048646 (0.36) ! anatomical structure formation involved in morphogenesis; GO:0007600 (0.36) ! sensory perception; GO:0007413 (0.36) ! axonal fasciculation; GO:1902578 (0.35) ! single-organism localization; GO:0048813 (0.35) ! dendrite morphogenesis; GO:0022607 (0.35) ! cellular component assembly; GO:0097090 (0.34) ! presynaptic membrane organization; GO:0050975 (0.34) ! sensory perception of touch; GO:0044765 (0.34) ! single-organism transport; GO:0007422 (0.33) ! peripheral nervous system development; GO:0010927 (0.31) ! cellular component assembly involved in morphogenesis GO:0031224 (0.93) ! intrinsic component of membrane; GO:0005886 (0.71) ! plasma membrane; GO:0044459 (0.66) ! plasma membrane part; GO:0097458 (0.59) ! neuron part; GO:0044421 (0.55) ! extracellular region part; GO:0043005 (0.53) ! neuron projection; GO:0030424 (0.52) ! axon; GO:0031226 (0.51) ! intrinsic component of plasma membrane; GO:0005887 (0.50) ! integral component of plasma membrane; GO:0030054 (0.43) ! cell junction; GO:0043025 (0.40) ! neuronal cell body; GO:0005576 (0.32) ! extracellular region; GO:0030425 (0.31) ! dendrite GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 44899712-44905390 (17q21.31) High: heart muscle (myocytes);smooth muscle (smooth muscle cells);Medium: testis (Leydig cells);cerebral cortex (neuronal cells);skeletal muscle (myocytes);caudate (neuronal cells);Low: cerebellum (Purkinje cells);placenta (trophoblastic cells);oral mucosa (squamous epithelial cells);hippocampus (neuronal cells);thyroid gland (glandular cells);small intestine (glandular cells);colon (glandular cells);gallbladder (glandular cells);esophagus (squamous epithelial cells);duodenum (glandular cells);kidney (cells in tubules);breast (myoepithelial cells); MHLALTTVLLWAWGLQAFEIVEKENIFQRTPCPAFLMFENAAYLADMSFELPCHCKPEEVPAVVWFYQKHLGSSHTKVLTDFDGRVLTEAAQVRVGSDMLTRFSIRMFSLLVFRAQSEDSGLYFCGTRKGDYFYAYDVDIQNSEGMVATFQDKGQEPFADEYYGHLHVFTTFWEWTPCDRCGVRGEQWRIGLCYLQSPDLSPRYLKAVPDVVSCGSRAVPRKLRTKARDHTPEVLVRSCLVPCEKTKTIREGVLAIINYVSKVGSRPWVPQVPIQFHQQRLGHGLIISCPGARPEHAVAWDKDRQHLYRTQYLKGVNRSMRVFIDHGNQLHIRFTQLDDRGIYYCWRQGVLVAGFRLGVTSHGHYPASFSDPETRSAVELTLIGYLLITAVFVTIHFCRCCCYLFHCCPSFSP LRRC37A Leucine-rich repeat-containing protein 37A L37A1_HUMAN (A6NMS7-1) GO:0048583 (0.32) ! regulation of response to stimulus GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 46292733-46337794 (17q21.31) High: testis (elongated or late spermatids; round or early spermatids);Low: testis (pachytene spermatocytes; preleptotene spermatocytes); Testis: 2.25; Brain - Cerebellar Hemisphere: 1.21; Pituitary: 1.17; Brain - Cerebellum: 1.05; Cervix - Endocervix: 1.02; Prostate: 1.01; Thyroid: 0.94; Uterus: 0.87; Nerve - Tibial: 0.86; Skin - Not Sun Exposed (Suprapubic): 0.86; Spleen: 0.80; Skin - Sun Exposed (Lower leg): 0.79; Vagina: 0.74; Lung: 0.72; Ovary: 0.72; Bladder: 0.70; Cervix - Ectocervix: 0.67; Colon - Sigmoid: 0.65; Cells - EBV-transformed lymphocytes: 0.61; Esophagus - Gastroesophageal Junction: 0.60; MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPESWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPAKALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSALSEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP LRRC37A2 Leucine-rich repeat-containing protein 37A2 L37A2_HUMAN (A6NM11-1) GO:0048583 (0.32) ! regulation of response to stimulus GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 46511511-46555650 (17q21.31) High: testis (elongated or late spermatids; round or early spermatids);Low: testis (pachytene spermatocytes; preleptotene spermatocytes); Testis: 12.15; Pituitary: 7.56; Brain - Cerebellar Hemisphere: 7.45; Brain - Cerebellum: 7.00; Prostate: 5.92; Skin - Not Sun Exposed (Suprapubic): 5.70; Thyroid: 5.67; Uterus: 5.59; Skin - Sun Exposed (Lower leg): 5.47; Nerve - Tibial: 5.36; Vagina: 5.28; Cervix - Ectocervix: 5.08; Ovary: 5.00; Bladder: 4.96; Spleen: 4.55; Cervix - Endocervix: 4.54; Lung: 4.52; Colon - Sigmoid: 3.93; Artery - Aorta: 3.72; Breast - Mammary Tissue: 3.70; MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPDSWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQPPDLGLAIIPEPTTETRHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVEPEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEKRLGSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTPKVKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSAPSEHFIENNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPHEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYINESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRSLQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDMYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP PRR15L Proline-rich protein 15-like protein PR15L_HUMAN (Q9BU68-1) GO:0044877 (0.31) ! macromolecular complex binding; GO:0005524 (0.31) ! ATP binding; GO:0004672 (0.31) ! protein kinase activity GO:0018108 (0.42) ! peptidyl-tyrosine phosphorylation; GO:0008283 (0.42) ! cell proliferation; GO:0006955 (0.42) ! immune response; GO:0006952 (0.42) ! defense response; GO:2001236 (0.31) ! regulation of extrinsic apoptotic signaling pathway; GO:2001234 (0.31) ! negative regulation of apoptotic signaling pathway; GO:0043068 (0.31) ! positive regulation of programmed cell death; GO:0022610 (0.31) ! biological adhesion GO:0044459 (0.58) ! plasma membrane part; GO:0005829 (0.58) ! cytosol; GO:0098590 (0.37) ! plasma membrane region; GO:0005886 (0.37) ! plasma membrane; GO:0043234 (0.32) ! protein complex; GO:0005634 (0.32) ! nucleus 1 47951967-47957878 (17q21.32) High: cerebellum (Purkinje cells);lymph node (non-germinal center cells);small intestine (glandular cells);placenta (decidual cells);seminal vesicle (glandular cells);bone marrow (hematopoietic cells);bronchus (respiratory epithelial cells);tonsil (non-germinal center cells);testis (Leydig cells);endometrium 2 (glandular cells);appendix (glandular cells);colon (endothelial cells; glandular cells);gallbladder (glandular cells);stomach 2 (glandular cells);nasopharynx (respiratory epithelial cells);lung (macrophages);rectum (glandular cells);skin 2 (epidermal cells);kidney (cells in glomeruli; cells in tubules);duodenum (glandular cells); Stomach: 125.00; Thyroid: 107.95; Small Intestine - Terminal Ileum: 100.50; Colon - Transverse: 100.50; Minor Salivary Gland: 84.31; Pancreas: 72.31; Lung: 42.94; Prostate: 30.08; Kidney - Cortex: 27.38; Esophagus - Mucosa: 17.34; Breast - Mammary Tissue: 15.47; Skin - Sun Exposed (Lower leg): 14.59; Pituitary: 13.06; Skin - Not Sun Exposed (Suprapubic): 9.46; Vagina: 9.20; Bladder: 6.10; Testis: 5.57; Fallopian Tube: 4.72; Adipose - Visceral (Omentum): 1.17; Liver: 0.97; MTTEIGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGDAEPPRPDAGGPNSDFNTRLEKIVDKSTKGKHVKVSNSGRFKEKKKVRATLAENPNLFDDHEEGRSSK FAM117A FAM117A F117A_HUMAN (Q9C073-1) GO:0022891 (0.51) ! substrate-specific transmembrane transporter activity; GO:0005459 (0.40) ! UDP-galactose transmembrane transporter activity GO:0048856 (0.44) ! anatomical structure development; GO:0003008 (0.40) ! system process; GO:0051179 (0.37) ! localization; GO:0072015 (0.36) ! glomerular visceral epithelial cell development; GO:0006810 (0.36) ! transport; GO:0003094 (0.36) ! glomerular filtration 2 49710332-49789180 (17q21.33) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);kidney (cells in tubules);testis (Leydig cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);duodenum (glandular cells);placenta (decidual cells; trophoblastic cells);parathyroid gland (glandular cells);urinary bladder (urothelial cells);appendix (glandular cells);breast (glandular cells; myoepithelial cells);rectum (glandular cells); Spleen: 45.19; Cells - EBV-transformed lymphocytes: 41.30; Uterus: 35.30; Whole Blood: 34.07; Testis: 33.86; Artery - Tibial: 32.15; Colon - Sigmoid: 30.59; Ovary: 30.38; Bladder: 29.34; Fallopian Tube: 27.13; Skin - Sun Exposed (Lower leg): 23.26; Artery - Coronary: 23.02; Esophagus - Gastroesophageal Junction: 22.82; Thyroid: 22.63; Skin - Not Sun Exposed (Suprapubic): 22.63; Artery - Aorta: 21.55; Pituitary: 21.19; Esophagus - Muscularis: 20.98; Small Intestine - Terminal Ileum: 20.40; Cervix - Endocervix: 18.95; MAGAAAGGRGGGAWGPGRGGAGGLRRGCSPPAPAGSPRAGLQPLRATIPFQLQQPHQRRDGGGRAASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERASSCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFVKEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDGSPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPGSPLPPASPRPPPRKDPEASKASPLPFEPWQRTPPSEEPVLFQSSLMV SAMD14 Sterile alpha motif domain-containing protein 14 SAM14_HUMAN (Q8IZD0-1) GO:0044877 (0.48) ! macromolecular complex binding; GO:0032403 (0.47) ! protein complex binding; GO:0051015 (0.45) ! actin filament binding; GO:1901363 (0.43) ! heterocyclic compound binding; GO:0097159 (0.43) ! organic cyclic compound binding; GO:0043169 (0.42) ! cation binding; GO:0097367 (0.41) ! carbohydrate derivative binding; GO:0017076 (0.41) ! purine nucleotide binding; GO:0035639 (0.40) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.40) ! adenyl ribonucleotide binding; GO:0032550 (0.40) ! purine ribonucleoside binding; GO:0016879 (0.40) ! ligase activity, forming carbon-nitrogen bonds GO:0030030 (0.49) ! cell projection organization; GO:0019932 (0.46) ! second-messenger-mediated signaling; GO:0031175 (0.45) ! neuron projection development; GO:0019722 (0.45) ! calcium-mediated signaling; GO:0007015 (0.44) ! actin filament organization GO:0097458 (0.53) ! neuron part; GO:0042995 (0.51) ! cell projection; GO:0044456 (0.50) ! synapse part; GO:0043005 (0.50) ! neuron projection; GO:0005856 (0.50) ! cytoskeleton; GO:0015629 (0.42) ! actin cytoskeleton; GO:0014069 (0.42) ! postsynaptic density; GO:0030425 (0.38) ! dendrite; GO:0005829 (0.33) ! cytosol 2 50110040-50129882 (17q21.33) Brain - Cerebellum: 129.40; Brain - Cerebellar Hemisphere: 128.30; Brain - Cortex: 37.99; Brain - Frontal Cortex (BA9): 34.44; Brain - Nucleus accumbens (basal ganglia): 32.69; Brain - Anterior cingulate cortex (BA24): 30.72; Brain - Amygdala: 24.09; Brain - Caudate (basal ganglia): 22.49; Brain - Putamen (basal ganglia): 20.32; Brain - Hippocampus: 19.82; Brain - Hypothalamus: 17.52; Brain - Substantia nigra: 10.44; Lung: 8.99; Artery - Aorta: 8.57; Brain - Spinal cord (cervical c-1): 6.31; Artery - Coronary: 6.27; Pituitary: 6.23; Prostate: 5.28; Testis: 4.72; Uterus: 4.63; MASSKLREPVDEVFDLDLAVPETARLDSSLHKARAQLLAKGRRHRPSRSRLRDSASSAEDGEGSDGPGGKVTDGCGSPLHRLRSPLHSGPGSPAGGSFCLDPPGLRRSLDEDEPPPSPLTRYRPLHNAASHEGLAAASCSPPRSAPSSDSSPSFVRRHPRAEPHSEDDSRDASPPEPASPTIGLDKKTRRKFLDLGVTLRRASTGKSRKEKGSNRLSMGSRESVEGSGRSGGSPFLPFSWFTDSGKGSASSGSTTSPTCSPKHEGFSPKKSASQESTLSDDSTPPSSSPKIPSGPWQEAKCSYPYHTLSQSSDEFLDEPLPPVHHWTSQQVGQWLQSLNLEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRALVKRKLKEMAAAAEKERKAQEKAARQREKLRRREQEAKKS ANKRD40 Ankyrin repeat domain-containing protein 40 ANR40_HUMAN (Q6AI12-1) GO:0019899 (0.64) ! enzyme binding; GO:0044389 (0.62) ! ubiquitin-like protein ligase binding; GO:0008092 (0.62) ! cytoskeletal protein binding; GO:0030507 (0.57) ! spectrin binding; GO:0008093 (0.57) ! cytoskeletal adaptor activity; GO:0044877 (0.51) ! macromolecular complex binding; GO:0008134 (0.51) ! transcription factor binding; GO:0005048 (0.50) ! signal sequence binding; GO:0005200 (0.49) ! structural constituent of cytoskeleton; GO:0051117 (0.48) ! ATPase binding GO:0051179 (0.60) ! localization; GO:0065008 (0.58) ! regulation of biological quality; GO:0050896 (0.58) ! response to stimulus; GO:0006355 (0.58) ! regulation of transcription, DNA-templated; GO:0006810 (0.57) ! transport; GO:0031325 (0.56) ! positive regulation of cellular metabolic process; GO:0023051 (0.56) ! regulation of signaling; GO:0010646 (0.56) ! regulation of cell communication; GO:0006357 (0.56) ! regulation of transcription from RNA polymerase II promoter; GO:1902578 (0.55) ! single-organism localization; GO:0051173 (0.55) ! positive regulation of nitrogen compound metabolic process; GO:0048583 (0.55) ! regulation of response to stimulus; GO:0009891 (0.55) ! positive regulation of biosynthetic process; GO:0006950 (0.55) ! response to stress; GO:1903508 (0.54) ! positive regulation of nucleic acid-templated transcription; GO:0051246 (0.54) ! regulation of protein metabolic process; GO:0009966 (0.54) ! regulation of signal transduction; GO:0051716 (0.53) ! cellular response to stimulus; GO:0051641 (0.53) ! cellular localization; GO:0042221 (0.53) ! response to chemical; GO:0032879 (0.53) ! regulation of localization; GO:0032268 (0.53) ! regulation of cellular protein metabolic process; GO:0002376 (0.53) ! immune system process; GO:1902531 (0.52) ! regulation of intracellular signal transduction; GO:0051247 (0.52) ! positive regulation of protein metabolic process; GO:0051049 (0.52) ! regulation of transport; GO:0048585 (0.52) ! negative regulation of response to stimulus; GO:0048584 (0.52) ! positive regulation of response to stimulus; GO:0045595 (0.52) ! regulation of cell differentiation; GO:0044802 (0.52) ! single-organism membrane organization; GO:0044765 (0.52) ! single-organism transport; GO:0044093 (0.52) ! positive regulation of molecular function; GO:0034613 (0.52) ! cellular protein localization; GO:0023057 (0.52) ! negative regulation of signaling; GO:0010941 (0.52) ! regulation of cell death; GO:0010648 (0.52) ! negative regulation of cell communication; GO:0010033 (0.52) ! response to organic substance; GO:0009628 (0.52) ! response to abiotic stimulus; GO:0009605 (0.52) ! response to external stimulus; GO:0007166 (0.52) ! cell surface receptor signaling pathway; GO:0006886 (0.52) ! intracellular protein transport; GO:1901700 (0.51) ! response to oxygen-containing compound; GO:0072661 (0.51) ! protein targeting to plasma membrane; GO:0071310 (0.51) ! cellular response to organic substance; GO:0051704 (0.51) ! multi-organism process; GO:0051241 (0.51) ! negative regulation of multicellular organismal process; GO:0051093 (0.51) ! negative regulation of developmental process; GO:0051051 (0.51) ! negative regulation of transport; GO:0051050 (0.51) ! positive regulation of transport; GO:0045596 (0.51) ! negative regulation of cell differentiation; GO:0043207 (0.51) ! response to external biotic stimulus; GO:0043069 (0.51) ! negative regulation of programmed cell death; GO:0042981 (0.51) ! regulation of apoptotic process; GO:0034097 (0.51) ! response to cytokine; GO:0033554 (0.51) ! cellular response to stress; GO:0033157 (0.51) ! regulation of intracellular protein transport; GO:0031347 (0.51) ! regulation of defense response; GO:0009968 (0.51) ! negative regulation of signal transduction; GO:0009719 (0.51) ! response to endogenous stimulus; GO:0009266 (0.51) ! response to temperature stimulus; GO:0002682 (0.51) ! regulation of immune system process; GO:1903707 (0.50) ! negative regulation of hemopoiesis; GO:1901652 (0.50) ! response to peptide; GO:0071222 (0.50) ! cellular response to lipopolysaccharide; GO:0070423 (0.50) ! nucleotide-binding oligomerization domain containing signaling pathway; GO:0051101 (0.50) ! regulation of DNA binding; GO:0051100 (0.50) ! negative regulation of binding; GO:0051091 (0.50) ! positive regulation of sequence-specific DNA binding transcription factor activity; GO:0050851 (0.50) ! antigen receptor-mediated signaling pathway; GO:0045637 (0.50) ! regulation of myeloid cell differentiation; GO:0044764 (0.50) ! multi-organism cellular process; GO:0044403 (0.50) ! symbiosis, encompassing mutualism through parasitism; GO:0043433 (0.50) ! negative regulation of sequence-specific DNA binding transcription factor activity; GO:0043331 (0.50) ! response to dsRNA; GO:0042994 (0.50) ! cytoplasmic sequestering of transcription factor; GO:0042347 (0.50) ! negative regulation of NF-kappaB import into nucleus; GO:0038093 (0.50) ! Fc receptor signaling pathway; GO:0032376 (0.50) ! positive regulation of cholesterol transport; GO:0010883 (0.50) ! regulation of lipid storage; GO:0010874 (0.50) ! regulation of cholesterol efflux; GO:0010743 (0.50) ! regulation of macrophage derived foam cell differentiation; GO:0009612 (0.50) ! response to mechanical stimulus; GO:0009409 (0.50) ! response to cold; GO:0008593 (0.50) ! regulation of Notch signaling pathway; GO:0008283 (0.50) ! cell proliferation; GO:0002224 (0.50) ! toll-like receptor signaling pathway; GO:0002220 (0.50) ! innate immune response activating cell surface receptor signaling pathway; GO:0016192 (0.49) ! vesicle-mediated transport; GO:0048193 (0.48) ! Golgi vesicle transport; GO:0006888 (0.47) ! ER to Golgi vesicle-mediated transport; GO:0048856 (0.35) ! anatomical structure development; GO:0010628 (0.35) ! positive regulation of gene expression; GO:0044707 (0.34) ! single-multicellular organism process; GO:0042391 (0.32) ! regulation of membrane potential; GO:0022607 (0.32) ! cellular component assembly GO:0005634 (0.65) ! nucleus; GO:0005886 (0.55) ! plasma membrane; GO:0044459 (0.51) ! plasma membrane part; GO:0043234 (0.51) ! protein complex; GO:0005829 (0.43) ! cytosol; GO:0097458 (0.34) ! neuron part GO:0005515 ! protein binding 3 GO:0005515 ! protein binding 50693190-50707924 (17q21.33) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in glomeruli; cells in tubules);testis (cells in seminiferous ducts);caudate (glial cells);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (cells in endometrial stroma; glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);pancreas (exocrine glandular cells; islets of Langerhans);cerebral cortex (endothelial cells; glial cells; neuronal cells);vagina (squamous epithelial cells);lymph node (germinal center cells; non-germinal center cells); Brain - Spinal cord (cervical c-1): 197.80; Brain - Substantia nigra: 113.60; Brain - Hippocampus: 73.81; Nerve - Tibial: 67.70; Brain - Putamen (basal ganglia): 66.50; Brain - Amygdala: 63.30; Muscle - Skeletal: 59.04; Brain - Hypothalamus: 57.57; Brain - Caudate (basal ganglia): 50.84; Artery - Tibial: 48.09; Brain - Cerebellar Hemisphere: 47.72; Adipose - Subcutaneous: 47.52; Colon - Sigmoid: 44.85; Brain - Cerebellum: 44.44; Uterus: 44.05; Bladder: 43.69; Cervix - Ectocervix: 42.92; Esophagus - Muscularis: 42.48; Brain - Frontal Cortex (BA9): 41.18; Brain - Nucleus accumbens (basal ganglia): 40.39; MNALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIMGVEEEDDDDDDDDNLPQLKKESELPFVPNYLANPAFPFIYTPTAEDSAQMQNGGPSTPPASPPADGSPPLLPPGEPPLLGTFPRDHTSLALVQNGDVSAPSAILRTPESTKPGPVCQPPVSQSRSLFSSVPSKPPMSLEPQNGTYAGPAPAFQPFFFTGAFPFNMQELVLKVRIQNPSLRENDFIEIELDRQELTYQELLRVCCCELGVNPDQVEKIRKLPNTLLRKDKDVARLQDFQELELVLMISENNFLFRNAASTLTERPCYNRRASKLTY C17orf67 Uncharacterized protein C17orf67 CQ067_HUMAN (Q0P5P2-1) GO:0043169 (0.58) ! cation binding; GO:0004112 (0.58) ! cyclic-nucleotide phosphodiesterase activity; GO:0032561 (0.48) ! guanyl ribonucleotide binding; GO:0030551 (0.48) ! cyclic nucleotide binding GO:0046068 (0.48) ! cGMP metabolic process; GO:0009214 (0.48) ! cyclic nucleotide catabolic process; GO:0009154 (0.48) ! purine ribonucleotide catabolic process; GO:2000243 (0.37) ! positive regulation of reproductive process; GO:1900542 (0.37) ! regulation of purine nucleotide metabolic process; GO:0090075 (0.37) ! relaxation of muscle; GO:0071902 (0.37) ! positive regulation of protein serine/threonine kinase activity; GO:0060281 (0.37) ! regulation of oocyte development; GO:0055117 (0.37) ! regulation of cardiac muscle contraction; GO:0050868 (0.37) ! negative regulation of T cell activation; GO:0050672 (0.37) ! negative regulation of lymphocyte proliferation; GO:0045988 (0.37) ! negative regulation of striated muscle contraction; GO:0045822 (0.37) ! negative regulation of heart contraction; GO:0043902 (0.37) ! positive regulation of multi-organism process; GO:0043410 (0.37) ! positive regulation of MAPK cascade; GO:0043405 (0.37) ! regulation of MAP kinase activity; GO:0042129 (0.37) ! regulation of T cell proliferation; GO:0030799 (0.37) ! regulation of cyclic nucleotide metabolic process; GO:0014742 (0.37) ! positive regulation of muscle hypertrophy; GO:0010720 (0.37) ! positive regulation of cell development; GO:0010611 (0.37) ! regulation of cardiac muscle hypertrophy GO:0005829 (0.53) ! cytosol GO:0005515 ! protein binding GO:0005576 ! extracellular region 2 GO:0005515 ! protein binding 56791913-56838773 (17q22) Uterus: 5.22; Testis: 5.08; Spleen: 4.93; Nerve - Tibial: 4.40; Prostate: 4.36; Ovary: 3.82; Cervix - Ectocervix: 3.81; Cervix - Endocervix: 3.79; Vagina: 3.75; Fallopian Tube: 3.56; Thyroid: 3.24; Lung: 3.03; Cells - EBV-transformed lymphocytes: 2.90; Small Intestine - Terminal Ileum: 2.83; Colon - Sigmoid: 2.81; Pituitary: 2.80; Bladder: 2.73; Artery - Aorta: 2.70; Esophagus - Muscularis: 2.51; Esophagus - Gastroesophageal Junction: 2.46; MASFKLADSVWEDSLSKRQRNQGRMKTLPVLVLSLTLLTVFSETSPILTEKQAKQLLRSRRQDRPSKPGFPDEPMREYMHHLLALEHRAEEQFLEHWLNPHCKPHCDRNRIHPV CUEDC1 CUE domain-containing protein 1 CUED1_HUMAN (Q9NWM3-1) GO:0022892 (0.35) ! substrate-specific transporter activity; GO:0019899 (0.32) ! enzyme binding GO:0016310 (0.52) ! phosphorylation GO:0005634 (0.85) ! nucleus; GO:0044428 (0.66) ! nuclear part; GO:0043234 (0.58) ! protein complex; GO:0070062 (0.56) ! extracellular exosome; GO:0005643 (0.54) ! nuclear pore; GO:0005829 (0.36) ! cytosol 2 57861243-57955323 (17q22) High: cerebellum (Purkinje cells);stomach 1 (glandular cells);Medium: stomach 2 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (neuronal cells);tonsil (germinal center cells; squamous epithelial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);smooth muscle (smooth muscle cells);heart muscle (myocytes);pancreas (exocrine glandular cells); Colon - Sigmoid: 57.87; Esophagus - Muscularis: 57.63; Esophagus - Gastroesophageal Junction: 55.70; Fallopian Tube: 48.62; Cervix - Endocervix: 48.50; Uterus: 43.13; Prostate: 43.07; Nerve - Tibial: 41.99; Artery - Tibial: 39.90; Cervix - Ectocervix: 39.56; Bladder: 39.04; Pituitary: 38.66; Brain - Spinal cord (cervical c-1): 38.15; Artery - Coronary: 38.02; Thyroid: 33.91; Vagina: 33.61; Artery - Aorta: 32.90; Muscle - Skeletal: 32.63; Minor Salivary Gland: 31.04; Lung: 30.79; MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ C17orf47 Uncharacterized protein C17orf47 CQ047_HUMAN (Q8NEP4-1) GO:1901363 (0.37) ! heterocyclic compound binding; GO:0097159 (0.37) ! organic cyclic compound binding; GO:0003676 (0.35) ! nucleic acid binding GO:0043234 (0.68) ! protein complex; GO:1990234 (0.34) ! transferase complex 1 58541587-58544368 (17q22) Testis: 14.73; Spleen: 0.24; Lung: 0.22; Thyroid: 0.18; Pituitary: 0.13; Breast - Mammary Tissue: 0.13; Minor Salivary Gland: 0.11; Bladder: 0.11; Prostate: 0.11; Cervix - Ectocervix: 0.11; Cervix - Endocervix: 0.09; Artery - Aorta: 0.09; Small Intestine - Terminal Ileum: 0.08; Artery - Tibial: 0.08; Liver: 0.08; Stomach: 0.07; Artery - Coronary: 0.07; Nerve - Tibial: 0.07; Colon - Transverse: 0.07; Skin - Sun Exposed (Lower leg): 0.06; MVKTNKPGAKVAVSAQRGSEVTTNTSPQQGHGYVLASSHRSAAVSLNPSHRRSEAAHPTTPHSASDYPRSVSLQSGPGHYAVPTPRGPETGPRTESSRHSSPHLKSQKTQTLASHASSRQWKVSPPREEAARRGSESKSGREVGHHASSIPDAKSTHQLSFQDQKNNLQSQILEDDPPSKVQNPQGVRVPRRILSYPKDEAVQTEPIQRITTTSEIRSPRSPSLLEHGSSCVSADYQTAQRRVPVEESETGPYGPIPSKPKALYRNMNLDSLLKLSVLKDSDGVHRVSARVDPESLHKYSAYPETKPSAKVLVSSQVESNVRTPIRGNSEVGRRVTISPGVQSVEPTHHVTVPSVSEGSHKSSMFVTPEPIYKQQTQKPPEITYMSQGPTPRYPELSQKPSIHAELELTPRPLPPRSLPRYGPDSSWWPLLNPEVETPQSQLTTPDFEPKCSPSLDLLLSGFKIDSSPFCEDLKFQREKASLSPPSPPKEFPSWAPLSEVPQTPKHTCKQPIQRFTAFFLDVSEEMYNRVIWWLKGLCFSLLWAHCGSLGDGRTGEEWHLCIYRAGSFRR C17orf82 Putative uncharacterized protein C17orf82 CQ082_HUMAN (Q86X59-1) GO:0015926 (0.39) ! glucosidase activity; GO:0003676 (0.34) ! nucleic acid binding GO:0048856 (0.48) ! anatomical structure development; GO:0051179 (0.45) ! localization; GO:0006810 (0.44) ! transport; GO:0043933 (0.42) ! macromolecular complex subunit organization; GO:0022607 (0.42) ! cellular component assembly; GO:0065003 (0.39) ! macromolecular complex assembly; GO:0051641 (0.39) ! cellular localization; GO:0051649 (0.38) ! establishment of localization in cell; GO:0048731 (0.38) ! system development; GO:0006139 (0.38) ! nucleobase-containing compound metabolic process; GO:0090304 (0.37) ! nucleic acid metabolic process; GO:0034622 (0.37) ! cellular macromolecular complex assembly; GO:0046907 (0.36) ! intracellular transport; GO:0022618 (0.36) ! ribonucleoprotein complex assembly; GO:0016070 (0.36) ! RNA metabolic process; GO:0009059 (0.36) ! macromolecule biosynthetic process; GO:0034654 (0.35) ! nucleobase-containing compound biosynthetic process; GO:0016071 (0.35) ! mRNA metabolic process; GO:0006913 (0.34) ! nucleocytoplasmic transport; GO:0006351 (0.34) ! transcription, DNA-templated; GO:0000398 (0.34) ! mRNA splicing, via spliceosome; GO:0009056 (0.33) ! catabolic process; GO:1901575 (0.31) ! organic substance catabolic process; GO:0005975 (0.31) ! carbohydrate metabolic process GO:0005576 (0.53) ! extracellular region; GO:0043234 (0.39) ! protein complex; GO:0005886 (0.33) ! plasma membrane GO:0005515 ! protein binding 1 GO:0005515 ! protein binding 61411751-61413280 (17q23.2) Lung: 3.77; Prostate: 3.53; Artery - Coronary: 2.90; Artery - Aorta: 2.71; Cervix - Endocervix: 2.65; Bladder: 2.29; Nerve - Tibial: 2.13; Artery - Tibial: 2.11; Uterus: 1.85; Cervix - Ectocervix: 1.80; Fallopian Tube: 1.68; Esophagus - Muscularis: 1.46; Minor Salivary Gland: 1.36; Ovary: 1.34; Testis: 1.26; Esophagus - Gastroesophageal Junction: 1.25; Thyroid: 1.20; Cells - Transformed fibroblasts: 1.13; Breast - Mammary Tissue: 1.08; Adipose - Subcutaneous: 1.07; MGRPLEGQPLRALDLYPEPAFLRSGKDPKSSPASSPSFAVLGPEVRSTGGQAGSRRRPSAPCSQDRAAAEGAPALLGGSPSSGSPGHPPGSAFGVEAGCRALNVSEHARGGFALGLPFGLSGGAYLFLLLDGAGDPKPTPEAPISSADGRAWFPSESSWQLPQLPAGSTSGSEPRARPGLGPRQLLTGPRDGAAGQGPGRGLTARLGREREIDCGPRQAGHGGTATDTGRAGSGARHRPPRDRGTPGLRTH EFCAB3 EF-hand calcium-binding domain-containing protein 3 EFCB3_HUMAN (Q8N7B9-1) GO:0043169 (0.74) ! cation binding; GO:0005509 (0.47) ! calcium ion binding GO:0019538 (0.58) ! protein metabolic process; GO:0050896 (0.43) ! response to stimulus; GO:0006464 (0.41) ! cellular protein modification process; GO:0051179 (0.40) ! localization; GO:0006468 (0.40) ! protein phosphorylation; GO:0046777 (0.39) ! protein autophosphorylation; GO:0042221 (0.39) ! response to chemical; GO:0018105 (0.39) ! peptidyl-serine phosphorylation; GO:0051234 (0.38) ! establishment of localization; GO:0010038 (0.37) ! response to metal ion; GO:0009738 (0.34) ! abscisic acid-activated signaling pathway GO:0005886 (0.66) ! plasma membrane; GO:0005634 (0.62) ! nucleus; GO:0043234 (0.45) ! protein complex; GO:0044459 (0.44) ! plasma membrane part; GO:0005829 (0.39) ! cytosol; GO:0044430 (0.38) ! cytoskeletal part; GO:0097458 (0.33) ! neuron part; GO:0031090 (0.31) ! organelle membrane GO:0005509 ! calcium ion binding; GO:0046872 ! metal ion binding 2 GO:0005509 ! calcium ion binding 62343941-62416479 (17q23.2) Testis: 6.95; Brain - Frontal Cortex (BA9): 0.01; MAVSEIKPKLKLNPLTKVPISHNKRDRDLPGSLQCQLQHKEKKLSASQMAAFQDAYNFFYKDKTGCIDFHGLMCTVAKLGMNLTKHDVYNELKCADIDRDGKVNFSDFIKVLTDKNLFLKAVVPEKETCLDLAGNPGILLFEILSRLLETSALPRKSIIEIVSYFQRKFQHTGPGMLWSPYTMGYGKRTLKPDICTPPSSSMAAFANAARIAIMKEKDLFKFLEELKRCNSGSDSPYSKIPIFPLFPNVDGVVMGKPFKDMQKLEMLRIKEPLHFFEDYFFHKRDWKTQAANIKSMDPASGYSNNIFTIDQMLKKKQTCTVADATAIKQHVKRATDTYNLGIALEHRKEMLNLWQKIRGDLIGMDSRNESFYDTFSTYTWSWNVCQELLSPKDLRLYDAYVNRNSSHNSRSSSSSDTSECYTDSGRKRKRKGLKGFQQ CEP95 Centrosomal protein of 95 kDa CEP95_HUMAN (Q96GE4-1) GO:0035639 (0.32) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.32) ! adenyl ribonucleotide binding; GO:0032550 (0.32) ! purine ribonucleoside binding; GO:0003676 (0.32) ! nucleic acid binding GO:0005813 (1.00) ! centrosome; GO:0000922 (1.00) ! spindle pole GO:0005813 ! centrosome; GO:0000922 ! spindle pole; GO:0005515 ! protein binding GO:0005815 ! microtubule organizing center; GO:0005737 ! cytoplasm; GO:0005856 ! cytoskeleton 4 GO:0005515 ! protein binding 64506588-64542461 (17q23.3) High: stomach 2 (glandular cells);small intestine (glandular cells);epididymis (glandular cells);appendix (glandular cells);colon (glandular cells);ovary (follicle cells);urinary bladder (urothelial cells);rectum (glandular cells);duodenum (glandular cells);Medium: stomach 1 (glandular cells);seminal vesicle (glandular cells);lung (macrophages; pneumocytes);gallbladder (glandular cells);kidney (cells in tubules);testis (Leydig cells);tonsil (squamous epithelial cells);endometrium 1 (cells in endometrial stroma; glandular cells);vagina (squamous epithelial cells);salivary gland (glandular cells);smooth muscle (smooth muscle cells); Ovary: 58.72; Thyroid: 51.52; Cervix - Endocervix: 50.88; Nerve - Tibial: 44.45; Brain - Cerebellar Hemisphere: 43.59; Testis: 43.59; Uterus: 39.58; Fallopian Tube: 38.16; Brain - Cerebellum: 37.24; Cervix - Ectocervix: 36.86; Prostate: 32.93; Colon - Sigmoid: 29.49; Skin - Not Sun Exposed (Suprapubic): 29.06; Vagina: 28.59; Skin - Sun Exposed (Lower leg): 28.48; Pituitary: 28.43; Bladder: 26.95; Breast - Mammary Tissue: 26.51; Artery - Tibial: 26.31; Spleen: 26.30; MAGSDAEWVTIANNLLFKCHIHLRIHELQDCDANVFIALYQSILGEKVPDLIVIPRSQEDDAHNVQAVIDSLALDYLQVSLSHITGENIVKGDKESIKNLLEIFDGLLEYLTERISETSHEKSETEQYFKESDRGERLEEPESTKESKSSWKRVSFGRCSLSSEMLGPSWDGDEAESTGEIIRLGDTAHTFSLRSNGAQCPNEMLSKKALASPSSKSHEDMLYPPSVLSKSRTSFVEDTETLSVSGIPNARKLGEPIRAAIPLHPPYHPSEPRAPCPIGKEYLHSSHCSPAVNSTGEHTEFSGDLDDGLFLISKLPKGSKWEVYPAQVQGPRTRKPPKGKRNENRATASSCNSPFPQRPRKRLTEQELHDVSEKLSQRLSELDWMLKSALGDRIKEKTDHKEENTGNEEVEDGTEETLSQHSDGIVEYGPKKSRPGLSMRRKPPYRSHSLSPSPVNKHKQFHLERKRQRKPRETDVRQFQAQAFTEAFERELRRHKVQENIGPLRIHEKEEETEKIYRGEAVRKGTPECSQPWKIYSRKTTTQSLRGGLPKPNKAVPMKVSEHSLLPLMLEQFPFLYVSGPTLSKMWKQQIAQVEQLKKEACRENRSKKKLQDEIEEALRRHDLLTTLVKKEYEHNKRLQDFKDCIRRQRLTQSKIKENRQQIVRARKYYDDYRVQLCAKMMRMRTREEMIFKKLFEEGLNIQKQRLRDLRNYAKEKRDEQRRRHQDELDSMENYYKDQFSLLAEAISQEHQELKAREKSQAQTLHKVKRELRSKMEKEIQQLQDMITQNDDDVFFRELEAERFRSRLQLASFQYSKSPSL LRRC37A3 Leucine-rich repeat-containing protein 37A3 L37A3_HUMAN (O60309-1) GO:0048583 (0.34) ! regulation of response to stimulus; GO:0007166 (0.32) ! cell surface receptor signaling pathway; GO:0009653 (0.31) ! anatomical structure morphogenesis GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 64854312-64919480 (17q24.1) High: testis (elongated or late spermatids; round or early spermatids);Low: testis (pachytene spermatocytes; preleptotene spermatocytes); Testis: 20.21; Pituitary: 14.32; Thyroid: 12.72; Brain - Cerebellar Hemisphere: 8.97; Brain - Cerebellum: 8.47; Brain - Hypothalamus: 5.96; Prostate: 5.39; Ovary: 4.94; Brain - Nucleus accumbens (basal ganglia): 4.81; Nerve - Tibial: 4.79; Brain - Cortex: 4.58; Brain - Frontal Cortex (BA9): 4.53; Fallopian Tube: 3.95; Kidney - Cortex: 3.85; Brain - Anterior cingulate cortex (BA24): 3.71; Brain - Caudate (basal ganglia): 3.62; Uterus: 3.45; Cervix - Endocervix: 3.26; Brain - Hippocampus: 3.06; Brain - Amygdala: 3.01; MTSAQCPALACVMSPLRFWGPWPLLMWQLLWLLVKEAQPLEWVKDPLQLTSNPLGPPEPWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQESTENLVPFLDTWDSAGELPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPTTEETSTQLPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELEPAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVPVPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILNHNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLIVPSHMACCLCQFKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIIEPEEPSDSSGINLSGFGSEQLDTNDESDVTSTLSYILPYFSAVNLDVKSLLLPFIKLPTTGNSLAKIQTVGKNRQRLNRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENTAEEKRLGSPAPRELKQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPAKALPQVRDRWKDLTHAISILESAKARVTNMKTSKPIVHSRKKYRFHKTRSRMTHRTPKVKKSPKVRKKSYLSRLMLSNRLPFSAAKSLINSPSQGAFSSLRDLSPQENPFLEVSAPSEHFIENNNTKDTTARNAFEENVFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGPTVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWKTENYINESTEAQSEQKEKSLEFTKELPGYGYTKKLILALIVTGILTILIILLCLIEICCHRRSLQEDEEGFSRDSEAPTEEESEALP C17orf58 UPF0450 protein C17orf58 CQ058_HUMAN (Q2M2W7-1) GO:0052548 (0.37) ! regulation of endopeptidase activity; GO:0010466 (0.37) ! negative regulation of peptidase activity GO:0005615 (0.67) ! extracellular space; GO:0005576 (0.67) ! extracellular region; GO:0031988 (0.60) ! membrane-bounded vesicle; GO:0070062 (0.53) ! extracellular exosome 2 67991101-67996431 (17q24.2) Cervix - Endocervix: 27.79; Cervix - Ectocervix: 25.84; Brain - Cerebellar Hemisphere: 20.25; Uterus: 18.65; Vagina: 17.90; Breast - Mammary Tissue: 16.43; Brain - Cerebellum: 15.99; Adipose - Subcutaneous: 14.13; Cells - Transformed fibroblasts: 13.85; Brain - Frontal Cortex (BA9): 12.89; Fallopian Tube: 12.55; Adipose - Visceral (Omentum): 12.51; Bladder: 12.12; Thyroid: 11.74; Brain - Anterior cingulate cortex (BA24): 10.80; Brain - Cortex: 10.39; Artery - Coronary: 10.17; Brain - Nucleus accumbens (basal ganglia): 9.74; Adrenal Gland: 9.63; Prostate: 9.51; MNRLYLTPDGFFFRVHMLALDSSSCNKPCPEFKPGSRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI FAM104A FAM104A F104A_HUMAN (Q969W3-1) GO:0006950 (0.81) ! response to stress; GO:0042276 (0.80) ! error-prone translesion synthesis GO:0043234 (0.85) ! protein complex; GO:0005634 (0.84) ! nucleus; GO:0061695 (0.81) ! transferase complex, transferring phosphorus-containing groups; GO:0016035 (0.80) ! zeta DNA polymerase complex; GO:0005829 (0.68) ! cytosol; GO:0031982 (0.51) ! vesicle; GO:0005886 (0.51) ! plasma membrane; GO:0031410 (0.45) ! cytoplasmic vesicle; GO:0030054 (0.45) ! cell junction; GO:0044459 (0.40) ! plasma membrane part; GO:0031988 (0.40) ! membrane-bounded vesicle; GO:0005773 (0.40) ! vacuole; GO:0005856 (0.34) ! cytoskeleton GO:0005515 ! protein binding 2 GO:0005515 ! protein binding 73207353-73236753 (17q25.1) Testis: 140.40; Cells - EBV-transformed lymphocytes: 49.85; Cells - Transformed fibroblasts: 34.17; Skin - Sun Exposed (Lower leg): 23.85; Skin - Not Sun Exposed (Suprapubic): 23.27; Cervix - Endocervix: 22.90; Cervix - Ectocervix: 22.40; Adipose - Subcutaneous: 21.89; Bladder: 21.26; Artery - Tibial: 21.19; Artery - Aorta: 20.76; Vagina: 20.54; Breast - Mammary Tissue: 20.18; Pituitary: 19.60; Fallopian Tube: 19.44; Artery - Coronary: 19.41; Esophagus - Mucosa: 18.98; Lung: 18.66; Thyroid: 18.64; Uterus: 18.59; MGGRGADAGSSGGTGPTEGYSPPAASTRAAARAKARGGGRGGRRNTTPSVPSLRGAAPRSFHPPAAMSERLRPRKRRRNGNEEDNHLPPQTKRSSRNPVFQDSWDTESSGSDSGGSSSSSSSSINSPDRASGPEGSLSQTMAGSSPNTPQPVPEQSALCQGLYFHINQTLREAHFHSLQHRGRPLT C17orf80 Uncharacterized protein C17orf80 CQ080_HUMAN (Q9BSJ5-1) GO:1901363 (0.43) ! heterocyclic compound binding; GO:0097159 (0.43) ! organic cyclic compound binding; GO:0097367 (0.40) ! carbohydrate derivative binding; GO:0035639 (0.39) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.39) ! adenyl ribonucleotide binding; GO:0032550 (0.39) ! purine ribonucleoside binding; GO:0008092 (0.35) ! cytoskeletal protein binding; GO:0003676 (0.35) ! nucleic acid binding GO:0065008 (0.44) ! regulation of biological quality; GO:0044707 (0.37) ! single-multicellular organism process GO:0070062 (0.97) ! extracellular exosome GO:0070062 ! extracellular exosome GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 73232233-73248947 (17q25.1) Testis: 36.04; Brain - Cerebellar Hemisphere: 19.23; Cervix - Endocervix: 18.88; Uterus: 18.29; Brain - Cerebellum: 17.64; Ovary: 17.46; Thyroid: 16.31; Fallopian Tube: 15.56; Colon - Sigmoid: 15.52; Cells - Transformed fibroblasts: 15.40; Pituitary: 15.35; Cells - EBV-transformed lymphocytes: 14.82; Bladder: 13.84; Esophagus - Gastroesophageal Junction: 13.82; Nerve - Tibial: 13.68; Esophagus - Muscularis: 13.63; Artery - Tibial: 13.11; Prostate: 13.10; Cervix - Ectocervix: 12.82; Artery - Coronary: 12.64; MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLPRAKKMKGPIKDLIKAKGKELETENEERNSKLVVDKPEQTVKTFPLPAVGLERAATTKADKDIKNPIQPSFKMLKNTKPMTTFQEETKAQFYASEKTSPKRELAKDLPKSGESRCNPSEAGASLLVGSIEPSLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLVKLLDVPTGDCHISPKNVSDGVKRVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTESLILSLKMSSLGKIQVMEKQEKGLTLGVETCGSKGNAEKSMSATEKQERTVMSHGCENFNTRDSVTGKESQGERPHLSLFIPRETTYQFHSVSQSSSQSLASLATTFLQEKKAEAQNHHCVPDVKALMESPEGQLSLEPKSDSQFQASHTGCQSPLCSAQRHTPQSPFTNHAAAAGRKTLRSCMGLEWFPELYPGYLGLGVLPGKPQCWNAMTQKPQLISPQGERLSQVSLLERSSTHIRSLEPPAGLTTSNFSLMRLLGAVQKGWIRCNTTIRKSGFGGITMLFTGYFVLCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTGDCRSKTCLD OTOP2 Otopetrin-2 OTOP2_HUMAN (Q7RTS6-1) GO:0046983 (0.55) ! protein dimerization activity; GO:0046873 (0.55) ! metal ion transmembrane transporter activity; GO:0042802 (0.55) ! identical protein binding; GO:0031420 (0.55) ! alkali metal ion binding; GO:0015077 (0.55) ! monovalent inorganic cation transmembrane transporter activity; GO:0009678 (0.39) ! hydrogen-translocating pyrophosphatase activity; GO:0004427 (0.39) ! inorganic diphosphatase activity GO:0042472 (1.00) ! inner ear morphogenesis; GO:0009590 (0.51) ! detection of gravity; GO:0045299 (0.49) ! otolith mineralization; GO:0032475 (0.49) ! otolith formation; GO:0098662 (0.41) ! inorganic cation transmembrane transport; GO:0030001 (0.41) ! metal ion transport GO:0005886 (0.35) ! plasma membrane; GO:0043234 (0.31) ! protein complex Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. {ECO:0000250|UniProtKB:Q80SX5}. GO:1902600 ! proton transmembrane transport; GO:0015252 ! proton channel activity GO:0005886 ! plasma membrane; GO:0016020 ! membrane; GO:0006811 ! ion transport; GO:0016021 ! integral component of membrane 2 74924275-74933912 (17q25.1) Colon - Transverse: 12.45; Testis: 10.48; Esophagus - Mucosa: 1.68; Small Intestine - Terminal Ileum: 1.53; Skin - Sun Exposed (Lower leg): 0.39; Uterus: 0.30; Skin - Not Sun Exposed (Suprapubic): 0.13; Vagina: 0.11; Brain - Cerebellum: 0.07; Cervix - Ectocervix: 0.06; Brain - Cerebellar Hemisphere: 0.06; Bladder: 0.05; Colon - Sigmoid: 0.05; Brain - Nucleus accumbens (basal ganglia): 0.03; Fallopian Tube: 0.02; Nerve - Tibial: 0.02; Spleen: 0.02; Minor Salivary Gland: 0.02; Adipose - Subcutaneous: 0.02; Adrenal Gland: 0.02; MSEELAQGPKESPPAPRAGPREVWKKGGRLLSVLLAVNVLLLACTLISGGAFNKVAVYDTDVFALLTAMMLLATLWILFYLLRTVRCPCAVPYRDAHAGPIWLRGGLVLFGICTLIMDVFKTGYYSSFFECQSAIKILHPLIQAVFVIIQTYFLWVSAKDCVHVHLDLTWCGLMFTLTTNLAIWMAAVVDESVHQSHSYSSSHSNASHARLISDQHADNPVGGDSCLCSTAVCQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRFLASTPGHSHTPTPVSLFRETFFAGPVLGLLLFVVGLAVFIIYEVQVSGDGSRTRQALVIYYSFNIVCLGLTTLVSLSGSIIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVAGTPQDLLAGLNLTHALLMIAQHTFQNMFIIESLHRGPPGAEPHSTHPKEPCQDLTFTNLDALHTLSACPPNPGLVSPSPSDQREAVAIVSTPRSQWRRQCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAVIVNICLPFGIFYRMHAVSSLLEVYVLS CDR2L Cerebellar degeneration-related protein 2-like CDR2L_HUMAN (Q86X02-1) GO:0016787 (0.46) ! hydrolase activity; GO:0017111 (0.45) ! nucleoside-triphosphatase activity; GO:0008092 (0.37) ! cytoskeletal protein binding; GO:1901363 (0.35) ! heterocyclic compound binding; GO:0097159 (0.35) ! organic cyclic compound binding; GO:0035639 (0.33) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.33) ! adenyl ribonucleotide binding; GO:0032550 (0.33) ! purine ribonucleoside binding GO:0022607 (0.37) ! cellular component assembly; GO:0007010 (0.36) ! cytoskeleton organization; GO:0070925 (0.33) ! organelle assembly; GO:0043933 (0.31) ! macromolecular complex subunit organization GO:0044430 (0.87) ! cytoskeletal part; GO:0043234 (0.64) ! protein complex; GO:0016459 (0.54) ! myosin complex; GO:0042995 (0.32) ! cell projection; GO:0032982 (0.31) ! myosin filament GO:0005515 ! protein binding 3 GO:0005515 ! protein binding 74987632-75005800 (17q25.1) High: cerebellum (cells in granular layer; Purkinje cells);placenta (decidual cells);small intestine (glandular cells);tonsil (germinal center cells; squamous epithelial cells);appendix (glandular cells; lymphoid tissue);gallbladder (glandular cells);stomach 2 (glandular cells);esophagus (squamous epithelial cells);rectum (glandular cells);cervix, uterine (squamous epithelial cells);duodenum (glandular cells);Medium: stomach 1 (glandular cells);colon (glandular cells; peripheral nerve/ganglion);kidney (cells in tubules);testis (cells in seminiferous ducts);caudate (neuronal cells);tonsil (non-germinal center cells);thyroid gland (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells); Brain - Cerebellum: 128.70; Brain - Cerebellar Hemisphere: 119.50; Brain - Spinal cord (cervical c-1): 55.35; Cells - Transformed fibroblasts: 30.72; Lung: 27.12; Artery - Aorta: 26.23; Cervix - Ectocervix: 24.84; Uterus: 24.66; Artery - Tibial: 23.05; Cervix - Endocervix: 22.42; Artery - Coronary: 22.34; Stomach: 21.27; Esophagus - Gastroesophageal Junction: 20.80; Brain - Substantia nigra: 20.39; Colon - Sigmoid: 19.69; Testis: 19.44; Esophagus - Muscularis: 18.70; Bladder: 16.37; Fallopian Tube: 16.36; Adipose - Visceral (Omentum): 16.01; MRRAAGMEDFSAEEEESWYDQQDLEQDLHLAAELGKTLLERNKELEGSLQQMYSTNEEQVQEIEYLTKQLDTLRHVNEQHAKVYEQLDLTARDLELTNHRLVLESKAAQQKIHGLTETIERLQAQVEELQAQVEQLRGLEQLRVLREKRERRRTIHTFPCLKELCTSPRCKDAFRLHSSSLELGPRPLEQENERLQTLVGALRSQVSQERQRKERAEREYTAVLQEYSELERQLCEMEACRLRVQELEAELLELQQMKQAKTYLLGPDDHLAEALLAPLTQAPEADDPQPGRGDDLGAQDGVSSPAASPGHVVRKSCSDTALNAIVAKDPASRHAGNLTLHANSVRKRGMSILREVDEQYHALLEKYEELLSKCRQHGAGVRHAGVQTSRPISRDSSWRDLRGGEEGQGEVKAGEKSLSQHVEAVDKRLEQSQPEYKALFKEIFSRIQKTKADINATKVKTHSSK TMEM94 Transmembrane protein 94 TMM94_HUMAN (Q12767-1) GO:0043492 (0.91) ! ATPase activity, coupled to movement of substances; GO:0022892 (0.91) ! substrate-specific transporter activity; GO:0019829 (0.74) ! cation-transporting ATPase activity; GO:0022890 (0.61) ! inorganic cation transmembrane transporter activity; GO:0015662 (0.61) ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; GO:0046873 (0.57) ! metal ion transmembrane transporter activity; GO:0015077 (0.41) ! monovalent inorganic cation transmembrane transporter activity; GO:0005524 (0.37) ! ATP binding; GO:0005391 (0.37) ! sodium:potassium-exchanging ATPase activity GO:0065008 (0.80) ! regulation of biological quality; GO:0098771 (0.77) ! inorganic ion homeostasis; GO:0030003 (0.77) ! cellular cation homeostasis; GO:0006875 (0.72) ! cellular metal ion homeostasis; GO:0006810 (0.71) ! transport; GO:0006812 (0.68) ! cation transport; GO:0034220 (0.66) ! ion transmembrane transport; GO:0098662 (0.65) ! inorganic cation transmembrane transport; GO:1902600 (0.64) ! hydrogen ion transmembrane transport; GO:0090662 (0.60) ! ATP hydrolysis coupled transmembrane transport; GO:0015988 (0.60) ! energy coupled proton transmembrane transport, against electrochemical gradient; GO:0030004 (0.57) ! cellular monovalent inorganic cation homeostasis; GO:0030001 (0.56) ! metal ion transport; GO:0071805 (0.52) ! potassium ion transmembrane transport; GO:0071436 (0.52) ! sodium ion export; GO:0055078 (0.52) ! sodium ion homeostasis; GO:0055075 (0.52) ! potassium ion homeostasis; GO:0006874 (0.35) ! cellular calcium ion homeostasis; GO:0032879 (0.31) ! regulation of localization GO:0005654 (1.00) ! nucleoplasm GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 75441159-75500090 (17q25.1) High: cerebellum (cells in molecular layer);hippocampus (glial cells);liver (hepatocytes);bronchus (respiratory epithelial cells);urinary bladder (urothelial cells);small intestine (glandular cells);colon (glandular cells);gallbladder (glandular cells);lung (macrophages);cerebral cortex (glial cells; neuropil);kidney (cells in tubules);duodenum (glandular cells);Medium: cerebellum (cells in granular layer);stomach 2 (glandular cells);stomach 1 (glandular cells);caudate (glial cells);seminal vesicle (glandular cells);parathyroid gland (glandular cells);thyroid gland (glandular cells);adrenal gland (glandular cells); MDLKEKHLGEPPSALGLSTRKALSVLKEQLEAVLEGHLRERKKCLTWKEVWRSSFLHHSNRCSCFHWPGASLMLLAVLLLLGCCGGQPAGSRGVGLVNASALFLLLLLNLVLIGRQDRLKRREVERRLRGIIDQIQDALRDGREIQWPSAMYPDLHMPFAPSWSLHWAYRDGHLVNLPVSLLVEGDIIALRPGQESFASLRGIKDDEHIVLEPGDLFPPFSPPPSPRGEVERGPQSPQQHRLFRVLETPVIDNIRWCLDMALSRPVTALDNERFTVQSVMLHYAVPVVLAGFLITNALRFIFSAPGVTSWQYTLLQLQVNGVLPILPLLFPVLWVLATACGEARVLAQMSKASPSSLLAKFSEDTLSSYTEAVSSQEMLRCIWGHFLRVLGGTSPTLSHSSSLLHSLGSVTVLCCVDKQGILSWPNPSPETVLFFSGKVEPPHSSHEDLTDGLSTRSFCHPEPHERDALLAGSLNNTLHLSNEQERGDWPGEAPKPPEPYSHHKAHGRSKHPSGSNVSFSRDTEGGEEEPSKTQPGMESDPYEAEDFVCDYHLEMLSLSQDQQNPSCIQFDDSNWQLHLTSLKPLGLNVLLNLCDASVTERLCRFSDHLCNIALQESHSAVLPVHVPWGLCELARLIGFTPGAKELFKQENHLALYRLPSAETMKETSLGRLSCVTKRRPPLSHMISLFIKDTTTSTEQMLSHGTADVVLEACTDFWDGADIYPLSGSDRKKVLDFYQRACLSGYCSAFAYKPMNCALSSQLNGKCIELVQVPGQSSIFTMCELPSTIPIKQNARRSSWSSDEGIGEVLEKEDCMQALSGQIFMGMVSSQYQARLDIVRLIDGLVNACIRFVYFSLEDELKSKVFAEKMGLETGWNCHISLTPNGDMPGSEIPPSSPSHAGSLHDDLNQVSRDDAEGLLLMEEEGHSDLISFQPTDSDIPSFLEDSNRAKLPRGIHQVRPHLQNIDNVPLLVPLFTDCTPETMCEMIKIMQEYGEVTCCLGSSANLRNSCLFLQSDISIALDPLYPSRCSWETFGYATSISMAQASDGLSPLQLSGQLNSLPCSLTFRQEETISIIRLIEQARHATYGIRKCFLFLLQCQLTLVVIQFLSCLVQLPPLLSTTDILWLSCFCYPLLSISLLGKPPHSSIMSMATGKNLQSIPKKTQHYFLLCFLLKFSLTISSCLICFGFTLQSFCDSSRDRNLTNCSSVMLPSNDDRAPAWFEDFANGLLSAQKLTAALIVLHTVFISITHVHRTKPLWRKSPLTNLWWAVTVPVVLLGQVVQTAVDLQLWTHRDSHVHFGLEDVPLLTWLLGCLSLVLVVVTNEIVKLHEIRVRVRYQKRQKLQFETKLGMNSPF CASKIN2 Caskin-2 CSKI2_HUMAN (Q8WXE0-1) GO:0016740 (0.39) ! transferase activity; GO:0019899 (0.31) ! enzyme binding GO:0005634 (0.36) ! nucleus GO:0016020 ! membrane; GO:0005737 ! cytoplasm 3 75500261-75515583 (17q25.1) High: stomach 2 (glandular cells);stomach 1 (glandular cells);cerebral cortex (endothelial cells);kidney (cells in glomeruli);Medium: colon (endothelial cells; glandular cells; peripheral nerve/ganglion);gallbladder (glandular cells);kidney (cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (glial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);duodenum (glandular cells);cerebral cortex (neuronal cells);placenta (trophoblastic cells);hippocampus (neuronal cells);bronchus (respiratory epithelial cells); Nerve - Tibial: 140.95; Lung: 78.05; Fallopian Tube: 61.11; Spleen: 55.80; Adipose - Visceral (Omentum): 50.51; Thyroid: 50.23; Breast - Mammary Tissue: 49.02; Uterus: 48.01; Adipose - Subcutaneous: 46.88; Artery - Coronary: 37.66; Cervix - Ectocervix: 36.87; Esophagus - Muscularis: 36.52; Cervix - Endocervix: 36.51; Esophagus - Gastroesophageal Junction: 35.62; Artery - Aorta: 33.79; Artery - Tibial: 32.97; Bladder: 32.05; Colon - Sigmoid: 30.59; Prostate: 30.14; Kidney - Cortex: 28.82; MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQEGTPSASTKHILDDISTMFDALADQLDAMLD SMIM5 Small integral membrane protein 5 SMIM5_HUMAN (Q71RC9-1) GO:0051015 (0.33) ! actin filament binding; GO:0030274 (0.33) ! LIM domain binding; GO:0017166 (0.33) ! vinculin binding; GO:0005200 (0.33) ! structural constituent of cytoskeleton; GO:0005178 (0.33) ! integrin binding GO:0098876 (0.48) ! vesicle-mediated transport to the plasma membrane; GO:0071702 (0.48) ! organic substance transport; GO:0051278 (0.48) ! fungal-type cell wall polysaccharide biosynthetic process; GO:0045184 (0.48) ! establishment of protein localization; GO:0030010 (0.48) ! establishment of cell polarity; GO:0006892 (0.48) ! post-Golgi vesicle-mediated transport; GO:0006038 (0.48) ! cell wall chitin biosynthetic process; GO:0000281 (0.48) ! mitotic cytokinesis; GO:0070527 (0.33) ! platelet aggregation; GO:0030866 (0.33) ! cortical actin cytoskeleton organization; GO:0007044 (0.33) ! cell-substrate junction assembly; GO:0007016 (0.33) ! cytoskeletal anchoring at plasma membrane GO:0043234 (0.60) ! protein complex; GO:0044431 (0.53) ! Golgi apparatus part; GO:0005794 (0.53) ! Golgi apparatus; GO:0031988 (0.47) ! membrane-bounded vesicle; GO:0070062 (0.40) ! extracellular exosome; GO:0044430 (0.40) ! cytoskeletal part; GO:0034044 (0.40) ! exomer complex; GO:0005925 (0.40) ! focal adhesion; GO:0005886 (0.40) ! plasma membrane; GO:0005856 (0.40) ! cytoskeleton; GO:0032587 (0.33) ! ruffle membrane; GO:0009986 (0.33) ! cell surface; GO:0005815 (0.33) ! microtubule organizing center; GO:0001726 (0.33) ! ruffle GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 75633434-75641404 (17q25.1) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in glomeruli; cells in tubules);testis (cells in seminiferous ducts; Leydig cells);caudate (glial cells; neuronal cells);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (cells in endometrial stroma; glandular cells);endometrium 2 (cells in endometrial stroma; glandular cells);salivary gland (glandular cells);smooth muscle (smooth muscle cells);pancreas (exocrine glandular cells; islets of Langerhans);cerebral cortex (endothelial cells; glial cells; neuronal cells);vagina (squamous epithelial cells); Nerve - Tibial: 22.75; Thyroid: 19.07; Esophagus - Mucosa: 17.48; Kidney - Cortex: 13.62; Vagina: 11.37; Brain - Spinal cord (cervical c-1): 10.94; Skin - Not Sun Exposed (Suprapubic): 10.23; Bladder: 9.60; Small Intestine - Terminal Ileum: 9.44; Skin - Sun Exposed (Lower leg): 9.41; Colon - Transverse: 6.65; Cervix - Endocervix: 5.65; Stomach: 5.16; Fallopian Tube: 4.81; Colon - Sigmoid: 4.11; Spleen: 4.00; Prostate: 3.37; Heart - Atrial Appendage: 3.31; Heart - Left Ventricle: 3.20; Cervix - Ectocervix: 3.15; MAATDFVQEMRAVGERLLLKLQRLPQAEPVEIVAFSVIILFTATVLLLLLIACSCCCTHCCCPERRGRKVQVQPTPP TRIM47 Tripartite motif-containing protein 47 TRI47_HUMAN (Q96LD4-1) GO:0004842 (0.76) ! ubiquitin-protein transferase activity; GO:0061630 (0.31) ! ubiquitin protein ligase activity GO:0019538 (0.54) ! protein metabolic process; GO:0006464 (0.50) ! cellular protein modification process; GO:0032446 (0.48) ! protein modification by small protein conjugation; GO:0016567 (0.47) ! protein ubiquitination; GO:0065008 (0.46) ! regulation of biological quality; GO:0044764 (0.46) ! multi-organism cellular process; GO:0051715 (0.43) ! cytolysis in other organism; GO:0010468 (0.41) ! regulation of gene expression; GO:2001141 (0.40) ! regulation of RNA biosynthetic process; GO:2000112 (0.40) ! regulation of cellular macromolecule biosynthetic process; GO:0006355 (0.39) ! regulation of transcription, DNA-templated; GO:0050896 (0.36) ! response to stimulus; GO:0048583 (0.34) ! regulation of response to stimulus; GO:0051246 (0.33) ! regulation of protein metabolic process; GO:0031325 (0.33) ! positive regulation of cellular metabolic process; GO:0032268 (0.32) ! regulation of cellular protein metabolic process GO:0005634 (0.41) ! nucleus; GO:0005576 (0.41) ! extracellular region; GO:0043234 (0.35) ! protein complex; GO:0044428 (0.32) ! nuclear part GO:0005829 ! cytosol GO:0008270 ! zinc ion binding; GO:0005622 ! intracellular; GO:0046872 ! metal ion binding; GO:0005737 ! cytoplasm; GO:0005634 ! nucleus 4 GO:0008270 ! zinc ion binding 75874161-75878575 (17q25.1) Colon - Sigmoid: 107.70; Esophagus - Muscularis: 103.45; Uterus: 93.57; Artery - Coronary: 88.97; Artery - Aorta: 88.82; Nerve - Tibial: 85.15; Artery - Tibial: 85.11; Spleen: 83.52; Esophagus - Gastroesophageal Junction: 79.69; Vagina: 74.13; Bladder: 73.08; Cervix - Ectocervix: 70.08; Cervix - Endocervix: 69.11; Fallopian Tube: 67.36; Adipose - Subcutaneous: 66.47; Skin - Sun Exposed (Lower leg): 65.64; Kidney - Cortex: 62.55; Breast - Mammary Tissue: 59.55; Lung: 58.64; Minor Salivary Gland: 57.92; MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRGASGAGGPGGAARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSGPGSGPGPAPALAPEPSAPSALPSVPEPSAPCAPEPWPAGEEPVRCDACPEGAALPAALSCLSCLASFCPAHLGPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRAERVCLCEACAAQEHRGHELVPLEQERALQEAEQSKVLSAVEDRMDELGAGIAQSRRTVALIKSAAVAERERVSRLFADAAAALQGFQTQVLGFIEEGEAAMLGRSQGDLRRQEEQRSRLSRARQNLSQVPEADSVSFLQELLALRLALEDGCGPGPGPPRELSFTKSSQAVRAVRDMLAVACVNQWEQLRGPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVKRVLCPINYPLSPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSMGVMAEDFSPQEPYDRGRLGRNAHSCCLQWNGRSFSVWFHGLEAPLPHPFSPTVGVCLEYADRALAFYAVRDGKMSLLRRLKASRPRRGGIPASPIDPFQSRLDSHFAGLFTHRLKPAFFLESVDAHLQIGPLKKSCISVLKRR UBALD2 UBA-like domain-containing protein 2 UBAD2_HUMAN (Q8IYN6-1) GO:1901363 (0.46) ! heterocyclic compound binding; GO:0097159 (0.46) ! organic cyclic compound binding; GO:0043169 (0.41) ! cation binding; GO:0016491 (0.40) ! oxidoreductase activity; GO:0046906 (0.39) ! tetrapyrrole binding; GO:0016684 (0.39) ! oxidoreductase activity, acting on peroxide as acceptor; GO:0016209 (0.39) ! antioxidant activity GO:0044248 (0.53) ! cellular catabolic process; GO:0050896 (0.44) ! response to stimulus; GO:0006950 (0.41) ! response to stress; GO:1990748 (0.39) ! cellular detoxification; GO:0042743 (0.39) ! hydrogen peroxide metabolic process GO:0005576 (0.55) ! extracellular region; GO:0043234 (0.44) ! protein complex; GO:0005634 (0.43) ! nucleus; GO:0044428 (0.42) ! nuclear part; GO:0044451 (0.36) ! nucleoplasm part 2 76265202-76271299 (17q25.1) Whole Blood: 205.60; Cells - EBV-transformed lymphocytes: 187.70; Spleen: 82.09; Lung: 78.72; Esophagus - Mucosa: 72.39; Muscle - Skeletal: 65.42; Small Intestine - Terminal Ileum: 64.23; Skin - Not Sun Exposed (Suprapubic): 63.97; Skin - Sun Exposed (Lower leg): 61.47; Nerve - Tibial: 58.06; Minor Salivary Gland: 52.82; Breast - Mammary Tissue: 48.19; Vagina: 47.25; Adipose - Subcutaneous: 46.07; Cells - Transformed fibroblasts: 44.98; Colon - Transverse: 44.66; Fallopian Tube: 43.82; Thyroid: 43.62; Prostate: 41.97; Bladder: 41.37; MSVNMDELRHQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIPNSHHHHQMMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAAACSPPANFSPFWASSPPSHQAPWIPPSSPTTFHHLHRPQPTWPPGAQQGGAQQKAMAAMDGQR QRICH2 Glutamine-rich protein 2 QRIC2_HUMAN (Q9H0J4-1) GO:0044430 (0.40) ! cytoskeletal part; GO:0043234 (0.36) ! protein complex 3 76274049-76307998 (17q25.1) High: testis (cells in seminiferous ducts); Testis: 51.16; Brain - Cerebellum: 13.10; Brain - Cerebellar Hemisphere: 12.40; Thyroid: 12.03; Nerve - Tibial: 5.78; Minor Salivary Gland: 5.09; Cervix - Endocervix: 4.52; Prostate: 4.47; Brain - Cortex: 4.36; Vagina: 4.11; Brain - Frontal Cortex (BA9): 4.02; Cervix - Ectocervix: 3.98; Uterus: 3.77; Brain - Hypothalamus: 3.75; Brain - Nucleus accumbens (basal ganglia): 3.67; Pituitary: 3.63; Fallopian Tube: 3.61; Lung: 3.56; Artery - Aorta: 3.55; Brain - Caudate (basal ganglia): 3.39; MKDAAEELSFARVLLQRVDELEKLFKDREQFLELVSRKLSLVPGAEEVTMVTWEELEQAITDGWRASQAGSETLMGFSKHGGFTSLTSPEGTLSGDSTKQPSIEQALDSASGLGPDRTASGSGGTAHPSDGVSSREQSKVPSGTGRQQQPRARDEAGVPRLHQSSTFQFKSDSDRHRSREKLTSTQPRRNARPGPVQQDLPLARDQPSSVPASQSQVHLRPDRRGLEPTGMNQPGLVPASTYPHGVVPLSMGQLGVPPPEMDDRELIPFVVDEQRMLPPSVPGRDQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEPLGMDQRGCVISGMGQQGLVPPGIDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPISADQQGFVQPSLEATGFIQPGTEQHDLIQSGRFQRALVQRGAYQPGLVQPGADQRGLVRPGMDQSGLAQPGADQRGLVWPGMDQSGLAQPGRDQHGLIQPGTGQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQRALVQPGAYQPGLVQPGADQIDVVQPGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQRGLAQPRADHQRGLVPPGADQRGLVQPGADQHGLVQPGVDQHGLAQPGEVQRSLVQPGIVQRGLVQPGAVQRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGADQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQPGADQPGLVQPGAGQLGMVQPGIGQQGMVQPQADPHGLVQPGAYPLGLVQPGAYLHDLSQSGTYPRGLVQPGMDQYGLRQPGAYQPGLIAPGTKLRGSSTFQADSTGFISVRPYQHGMVPPGREQYGQVSPLLASQGLASPGIDRRSLVPPETYQQGLMHPGTDQHSPIPLSTGLGSTHPDQQHVASPGPGEHDQVYPDAAQHGHAFSLFDSHDSMYPGYRGPGYLSADQHGQEGLDPNRTRASDRHGIPAQKAPGQDVTLFRSPDSVDRVLSEGSEVSSEVLSERRNSLRRMSSSFPTAVETFHLMGELSSLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQMVKRTIPPELQEQLKTVKTLAKEVWQEKAKVERLQRILEGEGNQEAGKELKAGELRLQLGVLRVTVADIEKELAELRESQDRGKAAMENSVSEASLYLQDQLDKLRMIIESMLTSSSTLLSMSMAPHKAHTLAPGQIDPEATCPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKKAKLQRQDEELLGRVQSAILQVQGDCEKLNITTSNLIEDHRQKQKDIAMLYQGLEKLEKEKANREHLEMEIDVKADKSALATKVSRVQFDATTEQLNHMMQELVAKMSGQEQDWQKMLDRLLTEMDNKLDRLELDPVKQLLEDRWKSLRQQLRERPPLYQADEAAAMRRQLLAHFHCLSCDRPLETPVTGHAIPVTPAGPGLPGHHSIRPYTVFELEQVRQHSRNLKLGSAFPRGDLAQMEQSVGRLRSMHSKMLMNIEKVQIHFGGSTKASSQIIRELLHAQCLGSPCYKRVTDMADYTYSTVPRRCGGSHTLTYPYHRSRPQHLPRGLYPTEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILRKDSSGTSKRKSQQPRPHVHRPPSLSSNGQLPSRPQSAQISAGNTSER MXRA7 Matrix-remodeling-associated protein 7 MXRA7_HUMAN (P84157-1) GO:0003676 (0.40) ! nucleic acid binding GO:0050896 (0.43) ! response to stimulus; GO:0051716 (0.37) ! cellular response to stimulus; GO:0006950 (0.31) ! response to stress GO:0005634 (0.59) ! nucleus; GO:0044428 (0.53) ! nuclear part GO:0031012 ! extracellular matrix GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 76672551-76711016 (17q25.1) Artery - Aorta: 150.00; Artery - Tibial: 143.10; Artery - Coronary: 121.90; Colon - Sigmoid: 114.40; Esophagus - Gastroesophageal Junction: 112.00; Esophagus - Muscularis: 106.80; Uterus: 99.08; Fallopian Tube: 81.21; Thyroid: 79.62; Cells - Transformed fibroblasts: 78.86; Bladder: 75.66; Nerve - Tibial: 73.11; Heart - Atrial Appendage: 71.21; Cervix - Endocervix: 67.54; Adipose - Subcutaneous: 65.00; Adrenal Gland: 61.58; Ovary: 60.34; Cervix - Ectocervix: 56.46; Adipose - Visceral (Omentum): 49.83; Lung: 48.97; MEAPAELLAALPALATALALLLAWLLVRRGAAASPEPARAPPEPAPPAEATGAPAPSRPCAPEPAASPAGPEEPGEPAGLGELGEPAGPGEPEGPGDPAAAPAEAEEQAVEARQEEEQDLDGEKGPSSEGPEEEDGEGFSFKYSPGKLRGNQYKKMMTKEELEEEQRVQKEQLAAIFKLMKDNKETFGEMSDGDVQEQLRLYDM MFSD11 UNC93-like protein MFSD11 MFS11_HUMAN (O43934-1) GO:0005215 (0.85) ! transporter activity; GO:0022857 (0.84) ! transmembrane transporter activity; GO:0022892 (0.78) ! substrate-specific transporter activity; GO:0022891 (0.77) ! substrate-specific transmembrane transporter activity; GO:0051119 (0.74) ! sugar transmembrane transporter activity; GO:0015145 (0.72) ! monosaccharide transmembrane transporter activity; GO:0015149 (0.71) ! hexose transmembrane transporter activity; GO:0005355 (0.70) ! glucose transmembrane transporter activity; GO:0008324 (0.67) ! cation transmembrane transporter activity; GO:0005351 (0.66) ! sugar:proton symporter activity; GO:0051183 (0.34) ! vitamin transporter activity; GO:0048029 (0.33) ! monosaccharide binding; GO:0015146 (0.33) ! pentose transmembrane transporter activity; GO:0015148 (0.32) ! D-xylose transmembrane transporter activity GO:0006810 (0.82) ! transport; GO:0071702 (0.70) ! organic substance transport; GO:0055085 (0.69) ! transmembrane transport; GO:0008643 (0.68) ! carbohydrate transport; GO:0015749 (0.67) ! monosaccharide transport; GO:0008645 (0.66) ! hexose transport; GO:0015758 (0.64) ! glucose transport; GO:0034219 (0.61) ! carbohydrate transmembrane transport; GO:0035428 (0.60) ! hexose transmembrane transport; GO:0046323 (0.47) ! glucose import; GO:0050896 (0.38) ! response to stimulus; GO:0006820 (0.38) ! anion transport; GO:0051716 (0.35) ! cellular response to stimulus; GO:0042221 (0.34) ! response to chemical; GO:1901700 (0.33) ! response to oxygen-containing compound; GO:0010033 (0.33) ! response to organic substance; GO:0098657 (0.32) ! import into cell; GO:0098704 (0.31) ! carbohydrate import across plasma membrane; GO:0044281 (0.31) ! small molecule metabolic process; GO:0015755 (0.31) ! fructose transport; GO:0015750 (0.31) ! pentose transport; GO:0015711 (0.31) ! organic anion transport; GO:0009746 (0.31) ! response to hexose GO:0005887 (0.77) ! integral component of plasma membrane; GO:0005886 (0.70) ! plasma membrane GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 3 76735865-76781449 (17q25.1) Testis: 20.45; Vagina: 16.40; Pituitary: 15.56; Cervix - Endocervix: 15.05; Cervix - Ectocervix: 14.95; Artery - Aorta: 14.94; Uterus: 13.99; Nerve - Tibial: 13.55; Skin - Sun Exposed (Lower leg): 13.54; Skin - Not Sun Exposed (Suprapubic): 13.50; Thyroid: 13.34; Lung: 13.32; Artery - Coronary: 12.76; Esophagus - Mucosa: 12.60; Spleen: 11.89; Bladder: 11.68; Adipose - Subcutaneous: 11.65; Minor Salivary Gland: 11.48; Artery - Tibial: 11.30; Breast - Mammary Tissue: 11.17; MSPESKKLFNIIILGVAFMFMFTAFQTCGNVAQTVIRSLNRTDFHGSGYTSMAIIYGVFSASNLITPSVVAIVGPQLSMFASGLFYSMYIAVFIQPFPWSFYTASVFIGIAAAVLWTAQGNCLTINSDEHSIGRNSGIFWALLQSSLFFGNLYIYFAWQGKTQISESDRRTVFIALTVISLVGTVLFFLIRKPDSENVLGEDESSDDQDMEVNESAQNNLTKAVDAFKKSFKLCVTKEMLLLSITTAYTGLELTFFSGVYGTCIGATNKFGAEEKSLIGLSGIFIGIGEILGGSLFGLLSKNNRFGRNPVVLLGILVHFIAFYLIFLNMPGDAPIAPVKGTDSSAYIKSSKEVAILCSFLLGLGDSCFNTQLLSILGFLYSEDSAPAFAIFKFVQSICAAVAFFYSNYLLLHWQLLVMVIFGFFGTISFFTVEWEAAAFVARGSDYRSI C17orf99 Uncharacterized protein C17orf99 CQ099_HUMAN (Q6UX52-1) GO:0004872 (0.63) ! receptor activity; GO:0004888 (0.56) ! transmembrane signaling receptor activity; GO:0004672 (0.53) ! protein kinase activity; GO:0019199 (0.50) ! transmembrane receptor protein kinase activity; GO:0097367 (0.49) ! carbohydrate derivative binding; GO:0035639 (0.47) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.47) ! adenyl ribonucleotide binding; GO:0032550 (0.47) ! purine ribonucleoside binding; GO:0046983 (0.39) ! protein dimerization activity GO:0009653 (0.60) ! anatomical structure morphogenesis; GO:0006928 (0.58) ! movement of cell or subcellular component; GO:0048856 (0.54) ! anatomical structure development; GO:0030030 (0.54) ! cell projection organization; GO:0032989 (0.53) ! cellular component morphogenesis; GO:0048812 (0.52) ! neuron projection morphogenesis; GO:0016477 (0.52) ! cell migration; GO:0006464 (0.51) ! cellular protein modification process; GO:0016310 (0.50) ! phosphorylation; GO:0061564 (0.48) ! axon development; GO:0018212 (0.48) ! peptidyl-tyrosine modification; GO:0000904 (0.48) ! cell morphogenesis involved in differentiation; GO:0048667 (0.47) ! cell morphogenesis involved in neuron differentiation; GO:0003008 (0.44) ! system process; GO:0050877 (0.41) ! neurological system process; GO:0048598 (0.41) ! embryonic morphogenesis; GO:0007155 (0.41) ! cell adhesion; GO:0007600 (0.40) ! sensory perception; GO:0050954 (0.39) ! sensory perception of mechanical stimulus; GO:0048840 (0.39) ! otolith development; GO:0042472 (0.39) ! inner ear morphogenesis; GO:0021675 (0.39) ! nerve development; GO:0050896 (0.38) ! response to stimulus; GO:0048583 (0.37) ! regulation of response to stimulus; GO:0045595 (0.36) ! regulation of cell differentiation; GO:0048513 (0.35) ! animal organ development; GO:0007166 (0.35) ! cell surface receptor signaling pathway; GO:0009966 (0.33) ! regulation of signal transduction; GO:0051179 (0.32) ! localization; GO:0048584 (0.32) ! positive regulation of response to stimulus; GO:0042221 (0.32) ! response to chemical; GO:0032879 (0.31) ! regulation of localization; GO:0010033 (0.31) ! response to organic substance; GO:0009605 (0.31) ! response to external stimulus; GO:0006810 (0.31) ! transport; GO:0002682 (0.31) ! regulation of immune system process; GO:0002376 (0.31) ! immune system process GO:0031224 (1.00) ! intrinsic component of membrane; GO:0005886 (0.90) ! plasma membrane; GO:0044459 (0.75) ! plasma membrane part; GO:0005887 (0.63) ! integral component of plasma membrane; GO:0031982 (0.42) ! vesicle; GO:0097458 (0.41) ! neuron part; GO:0042995 (0.40) ! cell projection; GO:0031988 (0.38) ! membrane-bounded vesicle; GO:0009986 (0.38) ! cell surface; GO:0043005 (0.35) ! neuron projection; GO:0030054 (0.35) ! cell junction; GO:0030424 (0.34) ! axon; GO:0044421 (0.32) ! extracellular region part GO:0002313 ! mature B cell differentiation involved in immune response; GO:0005615 ! extracellular space; GO:2000558 ! positive regulation of immunoglobulin production in mucosal tissue GO:0005576 ! extracellular region 2 78146353-78166177 (17q25.3) Cells - EBV-transformed lymphocytes: 3.62; Skin - Not Sun Exposed (Suprapubic): 0.37; Whole Blood: 0.36; Skin - Sun Exposed (Lower leg): 0.32; Spleen: 0.20; Vagina: 0.20; Esophagus - Mucosa: 0.15; Fallopian Tube: 0.11; Nerve - Tibial: 0.11; Ovary: 0.10; Lung: 0.10; Minor Salivary Gland: 0.09; Testis: 0.08; Small Intestine - Terminal Ileum: 0.08; Bladder: 0.07; Prostate: 0.06; Adipose - Subcutaneous: 0.05; Breast - Mammary Tissue: 0.05; Uterus: 0.04; Cervix - Ectocervix: 0.04; MGLPGLFCLAVLAASSFSKAREEEITPVVSIAYKVLEVFPKGRWVLITCCAPQPPPPITYSLCGTKNIKVAKKVVKTHEPASFNLNVTLKSSPDLLTYFCWASSTSGAHVDSARLQMHWELWSKPVSELRANFTLQDRGAGPRVEMICQASSGSPPITNSLIGKDGQVHLQQRPCHRQPANFSFLPSQTSDWFWCQAANNANVQHSALTVVPPGGDQKMEDWQGPLESPILALPLYRSTRRLSEEEFGGFRIGNGEVRGRKAAAM SYNGR2 Synaptogyrin-2 SNG2_HUMAN (O43760-1) GO:0043169 (0.37) ! cation binding GO:0006810 (0.66) ! transport; GO:0051649 (0.64) ! establishment of localization in cell; GO:0051641 (0.64) ! cellular localization; GO:0006605 (0.52) ! protein targeting; GO:0051049 (0.31) ! regulation of transport GO:0031594 (1.00) ! neuromuscular junction; GO:0030672 (1.00) ! synaptic vesicle membrane May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}. GO:0030672 ! synaptic vesicle membrane; GO:0005515 ! protein binding; GO:0070062 ! extracellular exosome; GO:0016021 ! integral component of membrane; GO:0048499 ! synaptic vesicle membrane organization; GO:0045055 ! regulated exocytosis; GO:0031594 ! neuromuscular junction GO:0030054 ! cell junction; GO:0005811 ! lipid droplet; GO:0031410 ! cytoplasmic vesicle; GO:0045202 ! synapse; GO:0016020 ! membrane; GO:0008021 ! synaptic vesicle; GO:0030659 ! cytoplasmic vesicle membrane 5 GO:0045055 ! regulated exocytosis; GO:0048499 ! synaptic vesicle membrane organization; GO:0005515 ! protein binding 78168558-78173527 (17q25.3) High: prostate (glandular cells);Medium: stomach 2 (glandular cells);stomach 1 (glandular cells);colon (glandular cells);gallbladder (glandular cells);tonsil (germinal center cells; non-germinal center cells; squamous epithelial cells);thyroid gland (glandular cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 2 (glandular cells);salivary gland (glandular cells);duodenum (glandular cells);cerebral cortex (endothelial cells);lymph node (germinal center cells; non-germinal center cells);parathyroid gland (glandular cells);urinary bladder (urothelial cells);small intestine (glandular cells);breast (glandular cells);rectum (glandular cells);pancreas (exocrine glandular cells); Cells - EBV-transformed lymphocytes: 348.30; Lung: 133.40; Spleen: 112.15; Minor Salivary Gland: 107.80; Prostate: 105.60; Skin - Not Sun Exposed (Suprapubic): 100.60; Skin - Sun Exposed (Lower leg): 100.50; Artery - Aorta: 90.22; Muscle - Skeletal: 89.39; Artery - Coronary: 80.53; Esophagus - Gastroesophageal Junction: 78.02; Brain - Spinal cord (cervical c-1): 75.15; Small Intestine - Terminal Ileum: 75.04; Esophagus - Mucosa: 74.43; Esophagus - Muscularis: 74.11; Pituitary: 73.59; Whole Blood: 71.61; Stomach: 70.48; Breast - Mammary Tissue: 69.88; Colon - Transverse: 67.47; MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY CEP295NL CEP295 N-terminal-like protein C295L_HUMAN (Q96MC4-1) GO:0016740 (0.50) ! transferase activity; GO:0036094 (0.45) ! small molecule binding; GO:1901981 (0.44) ! phosphatidylinositol phosphate binding; GO:0030234 (0.44) ! enzyme regulator activity; GO:0033218 (0.43) ! amide binding; GO:0030246 (0.43) ! carbohydrate binding; GO:0010485 (0.43) ! H4 histone acetyltransferase activity; GO:0008375 (0.43) ! acetylglucosaminyltransferase activity GO:0051179 (0.48) ! localization; GO:0048856 (0.47) ! anatomical structure development; GO:0065008 (0.44) ! regulation of biological quality; GO:0051641 (0.44) ! cellular localization; GO:0022607 (0.44) ! cellular component assembly; GO:0050896 (0.42) ! response to stimulus; GO:0006464 (0.42) ! cellular protein modification process; GO:0048513 (0.41) ! animal organ development; GO:0043933 (0.41) ! macromolecular complex subunit organization; GO:0032879 (0.41) ! regulation of localization; GO:0016310 (0.41) ! phosphorylation; GO:0010468 (0.40) ! regulation of gene expression; GO:0051716 (0.39) ! cellular response to stimulus; GO:0051640 (0.39) ! organelle localization; GO:0051049 (0.39) ! regulation of transport; GO:0048583 (0.39) ! regulation of response to stimulus; GO:0032880 (0.39) ! regulation of protein localization; GO:0032270 (0.39) ! positive regulation of cellular protein metabolic process; GO:0031399 (0.39) ! regulation of protein modification process; GO:0031324 (0.39) ! negative regulation of cellular metabolic process; GO:0023051 (0.39) ! regulation of signaling; GO:0010646 (0.39) ! regulation of cell communication; GO:0010605 (0.39) ! negative regulation of macromolecule metabolic process; GO:0009605 (0.39) ! response to external stimulus; GO:0006461 (0.39) ! protein complex assembly; GO:0006357 (0.39) ! regulation of transcription from RNA polymerase II promoter; GO:0006139 (0.39) ! nucleobase-containing compound metabolic process; GO:1902531 (0.38) ! regulation of intracellular signal transduction; GO:0060341 (0.38) ! regulation of cellular localization; GO:0051240 (0.38) ! positive regulation of multicellular organismal process; GO:0051129 (0.38) ! negative regulation of cellular component organization; GO:0051094 (0.38) ! positive regulation of developmental process; GO:0045595 (0.38) ! regulation of cell differentiation; GO:0043207 (0.38) ! response to external biotic stimulus; GO:0042221 (0.38) ! response to chemical; GO:0033044 (0.38) ! regulation of chromosome organization; GO:0032535 (0.38) ! regulation of cellular component size; GO:0031401 (0.38) ! positive regulation of protein modification process; GO:0010628 (0.38) ! positive regulation of gene expression; GO:0007166 (0.38) ! cell surface receptor signaling pathway; GO:0006325 (0.38) ! chromatin organization; GO:0001932 (0.38) ! regulation of protein phosphorylation; GO:2000379 (0.37) ! positive regulation of reactive oxygen species metabolic process; GO:1903829 (0.37) ! positive regulation of cellular protein localization; GO:1903578 (0.37) ! regulation of ATP metabolic process; GO:1903426 (0.37) ! regulation of reactive oxygen species biosynthetic process; GO:1903321 (0.37) ! negative regulation of protein modification by small protein conjugation or removal; GO:1901071 (0.37) ! glucosamine-containing compound metabolic process; GO:1900180 (0.37) ! regulation of protein localization to nucleus; GO:1900076 (0.37) ! regulation of cellular response to insulin stimulus; GO:1900037 (0.37) ! regulation of cellular response to hypoxia; GO:0090317 (0.37) ! negative regulation of intracellular protein transport; GO:0090313 (0.37) ! regulation of protein targeting to membrane; GO:0071396 (0.37) ! cellular response to lipid; GO:0071331 (0.37) ! cellular response to hexose stimulus; GO:0071229 (0.37) ! cellular response to acid chemical; GO:0071219 (0.37) ! cellular response to molecule of bacterial origin; GO:0070206 (0.37) ! protein trimerization; GO:0061085 (0.37) ! regulation of histone H3-K27 methylation; GO:0051569 (0.37) ! regulation of histone H3-K4 methylation; GO:0051291 (0.37) ! protein heterooligomerization; GO:0051260 (0.37) ! protein homooligomerization; GO:0051196 (0.37) ! regulation of coenzyme metabolic process; GO:0048585 (0.37) ! negative regulation of response to stimulus; GO:0048311 (0.37) ! mitochondrion distribution; GO:0048017 (0.37) ! inositol lipid-mediated signaling; GO:0046578 (0.37) ! regulation of Ras protein signal transduction; GO:0045893 (0.37) ! positive regulation of transcription, DNA-templated; GO:0044093 (0.37) ! positive regulation of molecular function; GO:0043967 (0.37) ! histone H4 acetylation; GO:0043470 (0.37) ! regulation of carbohydrate catabolic process; GO:0043467 (0.37) ! regulation of generation of precursor metabolites and energy; GO:0042327 (0.37) ! positive regulation of phosphorylation; GO:0033135 (0.37) ! regulation of peptidyl-serine phosphorylation; GO:0032526 (0.37) ! response to retinoic acid; GO:0032496 (0.37) ! response to lipopolysaccharide; GO:0031667 (0.37) ! response to nutrient levels; GO:0031396 (0.37) ! regulation of protein ubiquitination; GO:0031062 (0.37) ! positive regulation of histone methylation; GO:0030852 (0.37) ! regulation of granulocyte differentiation; GO:0030162 (0.37) ! regulation of proteolysis; GO:0018023 (0.37) ! peptidyl-lysine trimethylation; GO:0016601 (0.37) ! Rac protein signal transduction; GO:0012501 (0.37) ! programmed cell death; GO:0010941 (0.37) ! regulation of cell death; GO:0010799 (0.37) ! regulation of peptidyl-threonine phosphorylation; GO:0009749 (0.37) ! response to glucose; GO:0009636 (0.37) ! response to toxic substance; GO:0008361 (0.37) ! regulation of cell size; GO:0008286 (0.37) ! insulin receptor signaling pathway; GO:0007623 (0.37) ! circadian rhythm; GO:0007420 (0.37) ! brain development; GO:0006486 (0.37) ! protein glycosylation; GO:0006111 (0.37) ! regulation of gluconeogenesis; GO:0006096 (0.37) ! glycolytic process; GO:0002763 (0.37) ! positive regulation of myeloid leukocyte differentiation; GO:0001933 (0.37) ! negative regulation of protein phosphorylation; GO:0001678 (0.37) ! cellular glucose homeostasis; GO:0044087 (0.35) ! regulation of cellular component biogenesis; GO:1902115 (0.33) ! regulation of organelle assembly; GO:1902117 (0.32) ! positive regulation of organelle assembly GO:0043234 (0.63) ! protein complex; GO:0044430 (0.58) ! cytoskeletal part; GO:0005829 (0.43) ! cytosol; GO:0044428 (0.33) ! nuclear part; GO:0005634 (0.33) ! nucleus GO:0005929 ! cilium; GO:0042995 ! cell projection 2 78870910-78903217 (17q25.3) MCSGWSSSVIWRHTQFAVERCGFCGSSGPGAPLEPSTLGSKHLPWEAVSAGFADRNRNMDGAMWLSLCPDNEDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDRLQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLREFQNIC TEPSIN AP-4 complex accessory subunit Tepsin AP4AT_HUMAN (Q96N21-1) GO:0043167 (0.43) ! ion binding; GO:0043169 (0.42) ! cation binding GO:0043234 (0.63) ! protein complex; GO:0044428 (0.38) ! nuclear part; GO:1902494 (0.32) ! catalytic complex; GO:1990234 (0.31) ! transferase complex Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. {ECO:0000305|PubMed:22472443, ECO:0000305|PubMed:26542808}. GO:0030124 ! AP-4 adaptor complex; GO:0005794 ! Golgi apparatus; GO:0030662 ! coated vesicle membrane; GO:0032588 ! trans-Golgi network membrane; GO:0031312 ! extrinsic component of organelle membrane; GO:0005515 ! protein binding; GO:0005737 ! cytoplasm; GO:0031965 ! nuclear membrane; GO:0016607 ! nuclear speck GO:0031410 ! cytoplasmic vesicle; GO:0016020 ! membrane; GO:0005829 ! cytosol 5 GO:0005515 ! protein binding 81228277-81239091 (17q25.3) MAAAPPLRDRLSFLHRLPILLKGTSDDDVPCPGYLFEEIAKISHESPGSSQCLLEYLLSRLHSSSGHGKLKVLKILLYLCSHGSSFFLLILKRNSAFIQEAAAFAGPPDPLHGNSLYQKVRAAAQDLGSTLFSDTVLPLAPSQPLGTPPATGMGSQARPHSTLQGFGYSKEHGRTAVRHQPGQAGGGWDELDSGPSSQNSSQNSDLSRVSDSGSHSGSDSHSGASREPGDLAERVEVVALSDCQQELSLVRTVTRGPRAFLSREEAQHFIKACGLLNCEAVLQLLTCHLRGTSECTQLRALCAIASLGSSDLLPQEHILLRTRPWLQELSMGSPGPVTNKATKILRHFEASCGQLSPARGTSAEPGPTAALPGPSDLLTDAVPLPGSQVFLQPLSSTPVSSRSPAPSSGMPSSPVPTPPPDASPIPAPGDPSEAEARLAESRRWRPERIPGGTDSPKRGPSSCAWSRDSLFAGMELVACPRLVGAGAAAGESCPDAPRAPQTSSQRTAAKEPPGSEPSAFAFLNA OXLD1 Oxidoreductase-like domain-containing protein 1 OXLD1_HUMAN (Q5BKU9-1) GO:0016491 (0.87) ! oxidoreductase activity; GO:0000166 (0.82) ! nucleotide binding; GO:0071949 (0.73) ! FAD binding; GO:0004128 (0.73) ! cytochrome-b5 reductase activity, acting on NAD(P)H; GO:0016211 (0.52) ! ammonia ligase activity; GO:0035639 (0.33) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.33) ! adenyl ribonucleotide binding; GO:0032550 (0.33) ! purine ribonucleoside binding GO:0015701 (0.90) ! bicarbonate transport; GO:0009084 (0.53) ! glutamine family amino acid biosynthetic process; GO:0008652 (0.53) ! cellular amino acid biosynthetic process; GO:0006541 (0.53) ! glutamine metabolic process; GO:0071941 (0.34) ! nitrogen cycle metabolic process GO:0005739 (0.90) ! mitochondrion 1 81665036-81666635 (17q25.3) Testis: 62.40; Spleen: 58.87; Cells - EBV-transformed lymphocytes: 51.45; Prostate: 48.01; Cells - Transformed fibroblasts: 42.18; Thyroid: 41.66; Skin - Sun Exposed (Lower leg): 41.25; Skin - Not Sun Exposed (Suprapubic): 39.93; Pituitary: 37.22; Adrenal Gland: 34.71; Nerve - Tibial: 34.24; Fallopian Tube: 34.19; Bladder: 33.59; Breast - Mammary Tissue: 32.95; Uterus: 32.84; Lung: 32.09; Small Intestine - Terminal Ileum: 31.68; Stomach: 30.27; Vagina: 29.77; Esophagus - Mucosa: 29.77; MLLRRVVEGGRAVAAAVRGSGARRFSSPDCCQRLPGGGSFLQRHHPGAQAPDGRRKFGTDHVEVGSQAGADGTRPPKASLPPELQPPTNCCMSGCPNCVWVEYADRLLQHFQDGGERALAALEEHVADENLKAFLRMEIRLHTRCGG CCDC57 Coiled-coil domain-containing protein 57 CCD57_HUMAN (Q2TAC2-1) GO:0097367 (0.44) ! carbohydrate derivative binding; GO:0035639 (0.41) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.41) ! adenyl ribonucleotide binding; GO:0032550 (0.41) ! purine ribonucleoside binding; GO:0052813 (0.31) ! phosphatidylinositol bisphosphate kinase activity; GO:0052742 (0.31) ! phosphatidylinositol kinase activity; GO:0035004 (0.31) ! phosphatidylinositol 3-kinase activity; GO:0016307 (0.31) ! phosphatidylinositol phosphate kinase activity GO:0010468 (0.43) ! regulation of gene expression; GO:0048017 (0.41) ! inositol lipid-mediated signaling; GO:1901576 (0.34) ! organic substance biosynthetic process; GO:0016310 (0.32) ! phosphorylation; GO:0046834 (0.31) ! lipid phosphorylation; GO:0007017 (0.31) ! microtubule-based process; GO:0006928 (0.31) ! movement of cell or subcellular component; GO:0006661 (0.31) ! phosphatidylinositol biosynthetic process GO:0043234 (0.90) ! protein complex; GO:0005942 (0.85) ! phosphatidylinositol 3-kinase complex; GO:0005886 (0.69) ! plasma membrane; GO:0005829 (0.60) ! cytosol; GO:0044430 (0.47) ! cytoskeletal part; GO:0044421 (0.35) ! extracellular region part; GO:0005773 (0.34) ! vacuole; GO:0044428 (0.33) ! nuclear part; GO:0042995 (0.32) ! cell projection; GO:0031982 (0.32) ! vesicle; GO:0031988 (0.31) ! membrane-bounded vesicle GO:0005515 ! protein binding 5 GO:0005515 ! protein binding 82101460-82212830 (17q25.3) High: stomach 2 (glandular cells);stomach 1 (glandular cells);seminal vesicle (glandular cells);colon (endothelial cells; glandular cells);gallbladder (glandular cells);esophagus (squamous epithelial cells);kidney (cells in glomeruli; cells in tubules);testis (cells in seminiferous ducts);tonsil (squamous epithelial cells);vagina (squamous epithelial cells);epididymis (glandular cells);adrenal gland (glandular cells);endometrium 1 (glandular cells);thyroid gland (glandular cells);salivary gland (glandular cells);heart muscle (myocytes);cerebral cortex (neuronal cells);lymph node (non-germinal center cells);placenta (trophoblastic cells);bronchus (respiratory epithelial cells); Thyroid: 27.31; Brain - Cerebellum: 23.59; Pituitary: 22.78; Testis: 21.43; Brain - Cerebellar Hemisphere: 20.41; Prostate: 19.98; Ovary: 19.02; Uterus: 18.12; Fallopian Tube: 17.73; Cervix - Endocervix: 13.96; Lung: 13.74; Cervix - Ectocervix: 13.68; Nerve - Tibial: 13.09; Minor Salivary Gland: 12.21; Bladder: 12.18; Breast - Mammary Tissue: 11.65; Colon - Sigmoid: 10.78; Vagina: 9.88; Spleen: 9.00; Cells - Transformed fibroblasts: 8.94; MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGREQDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLGSSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAKGCQRPPKIRNYNIMD C17orf62 Uncharacterized protein C17orf62 CQ062_HUMAN (Q9BQA9-1) GO:0035639 (0.57) ! purine ribonucleoside triphosphate binding; GO:0032559 (0.57) ! adenyl ribonucleotide binding; GO:0032550 (0.57) ! purine ribonucleoside binding; GO:0051427 (0.37) ! hormone receptor binding; GO:0031701 (0.37) ! angiotensin receptor binding; GO:0005126 (0.37) ! cytokine receptor binding; GO:0004672 (0.37) ! protein kinase activity GO:0044351 (0.83) ! macropinocytosis; GO:0048870 (0.32) ! cell motility; GO:0046777 (0.32) ! protein autophosphorylation; GO:0018108 (0.32) ! peptidyl-tyrosine phosphorylation; GO:0008283 (0.32) ! cell proliferation; GO:0006955 (0.32) ! immune response; GO:0006952 (0.32) ! defense response GO:0044430 (0.74) ! cytoskeletal part; GO:0005856 (0.74) ! cytoskeleton; GO:0005874 (0.68) ! microtubule; GO:0005829 (0.68) ! cytosol; GO:0005871 (0.63) ! kinesin complex; GO:0005634 (0.53) ! nucleus; GO:0005815 (0.42) ! microtubule organizing center; GO:0005819 (0.37) ! spindle; GO:0005876 (0.32) ! spindle microtubule GO:0005515 ! protein binding GO:0016020 ! membrane; GO:0016021 ! integral component of membrane 2 GO:0005515 ! protein binding 82442589-82450829 (17q25.3) Whole Blood: 173.20; Spleen: 169.90; Cells - EBV-transformed lymphocytes: 118.10; Cervix - Endocervix: 65.07; Lung: 59.58; Prostate: 58.26; Nerve - Tibial: 57.70; Fallopian Tube: 52.90; Uterus: 49.19; Bladder: 48.54; Small Intestine - Terminal Ileum: 48.16; Ovary: 46.64; Thyroid: 43.98; Adipose - Subcutaneous: 43.76; Cervix - Ectocervix: 43.38; Artery - Aorta: 42.93; Artery - Coronary: 42.37; Breast - Mammary Tissue: 42.05; Pituitary: 41.88; Cells - Transformed fibroblasts: 41.58; MYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYFGKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEAGDPASQS