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DAMpred is a method to predict what gene mutations can cause human diseases and what mutations do not do so. Starting with a protein sequence and specified non-synonymous single nucleotide polymorphisms (nsSNPs), DAMpred calculates the probability of the mutations to be deleterious or neutral to human health. The calculation is built on a deep-learning model that integrates three sources of information from sequence profiles, biological assembly and 3D structure model (by I-TASSER), which is trained through a novel Bayes-guided artificial neural network (BANN) algorithm (>> more about DAMpred ...).



DAMpred On-line (View an example of output)

  1. Protein sequence in FASTA format (length should be in [10,1500])
    Please copy and paste your protein sequence below (Click for an example FASTA input):

    Or upload the sequence file:

  2. Specify single-point mutations
    Please input a list of mutations, where one mutation per line (Click for an example list of mutations):


    Email: (Mandatory, where results will be sent to)

    ID: (Optional, your given name to this protein)


DAMpred Downloads
References

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218


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