COVID-19 peptide binders download
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De novo design of peptide binders targeting SARS-CoV-2 spike protein
- It has been confirmed that SARS-CoV-2 initiates its entry into host cells by binding to the angiotensin-converting enzyme 2 (ACE2) via the receptor binding domain (RBD) of its spike protein. Therefore, it is possible to develop new therapeutics to block SARS-CoV-2 from binding to ACE2. we computationally designed thousands of peptide binders that exhibited stronger binding affinity for SARS-CoV-2 than the natural peptides through computational examination. Due to the urgent situation caused by COVID-19 and the limited resources in our own laboratory, we share these computational data to the scientific community and hope researchers can work together to test them and to develop potential antiviral peptide therapeutics to combat this pandemic.
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Reference
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Xiaoqiang Huang, Robin Pearce, Yang Zhang. Computational Design of Peptides to Block Binding of the SARS-CoV-2 Spike Protein to Human ACE2.
Submitted, 2020.