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GLASS (GPCR-Ligand Association) database is a manually curated repository for experimentally-validated GPCR-ligand interactions. Along with relevant GPCR and chemical information, GPCR-ligand association data are extracted and integrated into GLASS from literature and public databases. (>>more about the GLASS database)

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GLASS News

The current database was updated on November 1, 2018, which contains:

  • Unique GPCR-ligand entries: 551,547
  • GPCR entries: 3,056
    • Human GPCR: 825
    • GPCRs that have experimental association data: 733
  • Ligand entries: 335,271
    • Lipinski-druglike ligands: 235,740

July 13, 2018: Add TSV files for interaction data filtered (by Kd, Ki, IC50, EC50) for active and inactive compounds in 'Download' section.
July 12, 2018: Replaced JMol viewer with NGL viewer. All GPCR structures are now loaded directly from GPCR-EXP, a new database we developed for experimentally-solved and predicted GPCR structures.
November 2, 2017: Fixed bug in update script that missed BioLiP entries from 2015 and onwards.
October 4, 2017: Fixed bug where searching with a ligand name as a query could result in an internal server error. Also fixed problem where synonym lists would not expand when clicked.
February 14, 2017: Happy Valentine's Day! The browse ligand and browse family features have been fixed. Thank you to Hongjiu Zhang for assistance.
August 5, 2016: Added 2D molecule structures to GPCR search results. Thank you to Dr. Andrew Horti for this useful suggestion. This change should hopefully facilitate the browsing of molecules.
June 24, 2016: Fixed bug where DrugBank entries were not showing up.
March 1, 2015: Redesigned the database schemas.
February 17, 2015: Migrated the website to the new framework.
August 12, 2014: Added searches for GPCR by family and for ligands by chemical structure.
June 30, 2014: Added batch TSV and SDF download.
June 28, 2014: Added synonyms for GPCRs and ligands, as well as Lipinski's rule of five check.
June 24, 2014: Set up the database website.

GPCR Related databases

References

W Chan, H Zhang, J Yang, J Brender, J Hur, A Ozgur, Y Zhang. GLASS: a comprehensive database for experimentally-validated GPCR-ligand associations. Bioinformatics, 31: 3035-3042 (2015). [PDF] [Support Information] [Database]

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