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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	2,2-Dimethyl-3-(nitrooxy)propanoic acid
Molecular formula	C5H9NO5
IUPAC name	2,2-dimethyl-3-nitrooxypropanoic acid
Molecular weight	163.129
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	0.9
Synonyms	ANW-54102 KB-224871 Z4072 2,2-dimethyl-3-(nitrooxy) propanoic acid CHEMBL361225 MolPort-023-329-988 AB0051039 DTXSID80437971 ST24021445 AX8218254 KS-000024O1 ZINC28358176 CTK8B6708 Propanoic acid, 2,2-dimethyl-3-(nitrooxy)- AKOS016001376 FCH1562731 TC-142847 130432-36-9 M-9672 4CH-010890 DS-2170 SCHEMBL2015730 [ Show all ]
Inchi Key	AOADQMBSEJVBHG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C5H9NO5/c1-5(2,4(7)8)3-11-6(9)10/h3H2,1-2H3,(H,7,8)
PubChem CID	10313259
ChEMBL	CHEMBL361225
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pD2	4.69 -	PMID15341967	ChEMBL

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