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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd1
Synonym	D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor Gpcr15 [ Show all ]
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProt	P18901
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL265
IUPHAR	214
DrugBank	N/A

Ligand

Name	UNII-UGT5535REQ
Molecular formula	C17H18ClNO
IUPAC name	(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
Molecular weight	287.787
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.0
Synonyms	2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol (R)- BRD-K45435259-001-01-6 GOTMKOSCLKVOGG-OAHLLOKOSA-N PDSP2_000612 SCH23390 87075-17-0 CCG-204548 NCGC00024877-02 Sch 23388 UGT5535REQ 1H-3-Benzazepin-7-ol, 2,3,4,5-tetrahydro-8-chloro-3-methyl-5-phenyl-, (R)- Biomol-NT_000016 CHEMBL62 PDSP1_000615 SCH 23390,R(+) 8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SCH 23390) BRD-K45435259-003-03-8 Lopac0_000456 PDSP2_001507 SCHEMBL2916216 (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol AC1MI1XB CHEBI:92798 NCGC00024877-03 SCH 23390 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, (R)- BPBio1_001173 CTK3F0072 PDSP1_001523 SCH-23390 CAS_87134-87-0 NCGC00024877-01 r-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine Tocris-0925 (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol BDBM82247 NCGC00024877-04 SCH 23390 (R-enantiomer) ZINC2017838 [ Show all ]
Inchi Key	GOTMKOSCLKVOGG-OAHLLOKOSA-N
Inchi ID	InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
PubChem CID	3036864
ChEMBL	CHEMBL62
IUPHAR	N/A
BindingDB	82247
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
-Log K0.5	9.4 -	PMID10464009	ChEMBL
Change	-35.0 %	PMID12723940	ChEMBL
Change	52.0 %	PMID12723940	ChEMBL
Change	62.0 %	PMID12723940	ChEMBL
IC50	0.57 nM	PMID7830274	BindingDB,ChEMBL
IC50	1.0 nM	PMID1971308	BindingDB,ChEMBL
IC50	1.01 nM	PMID7914538	BindingDB,ChEMBL
IC50	1.3 nM	PMID2405158	BindingDB,ChEMBL
IC50	4.3 nM	PMID9804688	BindingDB,ChEMBL
K 0.5	0.4 nM	PMID10072690	ChEMBL
K0.5	0.3 nM	PMID8558526	ChEMBL
K0.5	0.5 nM	PMID8568818, PMID9216832	ChEMBL
K0.5	0.52 nM	PMID7636869	ChEMBL
Ki	0.12 nM	PMID10843230	ChEMBL
Ki	0.12 nM	PMID10843230	BindingDB
Ki	0.14 nM	PMID2415793, PMID1397049, PMID3039136, PMID7855175	BindingDB,ChEMBL
Ki	0.2 nM	PMID8584042	BindingDB
Ki	0.21 nM	PMID7473556	BindingDB,ChEMBL
Ki	0.3 nM	PMID6387355, Bioorg. Med. Chem. Lett., (1992) 2:5:399	BindingDB,ChEMBL
Ki	0.3 nM	N/A	BindingDB
Ki	0.34 nM	PMID12023552	BindingDB
Ki	0.37 nM	PMID10327430	BindingDB
Ki	0.39 nM	PMID2525621	BindingDB,ChEMBL
Ki	0.4 nM	PMID2666667, PMID2905002, PMID7996543	BindingDB,ChEMBL
Ki	0.4 nM	PMID7996543	BindingDB
Ki	0.4266 nM	PMID7996543	ChEMBL
Ki	0.43 nM	PMID3050089	ChEMBL
Ki	0.43 nM	PMID3050089	BindingDB
Ki	0.73 nM	PMID8863801	BindingDB,ChEMBL
Ki	0.7413 nM	PMID10691686	ChEMBL
Ki	0.8 nM	PMID7902811	BindingDB
Ki	0.9 nM	PMID1833546	ChEMBL
Ki	0.9 nM	PMID1833546	BindingDB
Ki	1.4 nM	PMID10227113	BindingDB
Ki	17.0 nM	PMID8558526	BindingDB
Ki	173.0 nM	PMID1397049	BindingDB
Ki	178.0 nM	PMID2531826	BindingDB
Ki	676.0 nM	PMID7996543	BindingDB,ChEMBL