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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesBos taurus (Bovine)
GeneHTR2A
Synonym5-HT-2
5-HT-2A
Serotonin receptor 2A
DiseaseN/A for non-human GPCRs
Length470
Amino acid sequenceMDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
UniProtQ75Z89
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3446
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL298649
Molecular formulaC22H22FN5
IUPAC name7-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-10-methyl-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene
Molecular weight375.451
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.3
SynonymsSCHEMBL8570048
BDBM50408176
Inchi KeyAOIREBHOLIZUIV-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H22FN5/c1-16-8-9-24-22-20(16)25-21(19-3-2-10-28(19)22)27-13-11-26(12-14-27)15-17-4-6-18(23)7-5-17/h2-10H,11-15H2,1H3
PubChem CID10714509
ChEMBLCHEMBL298649
IUPHARN/A
BindingDB50408176
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<100000.0 nMPMID9191957BindingDB,ChEMBL

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