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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1090559
Molecular formula	C24H39N5O5S
IUPAC name	propan-2-yl 4-[[6-(4-piperidin-1-ylsulfonylpiperazin-1-yl)pyridin-3-yl]oxymethyl]piperidine-1-carboxylate
Molecular weight	509.666
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	2.5
Synonyms	BDBM50315152 isopropyl 4-((6-(4-(piperidin-1-ylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)methyl)piperidine-1-carboxylate
Inchi Key	AOLJFWZJDVEKRK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H39N5O5S/c1-20(2)34-24(30)27-12-8-21(9-13-27)19-33-22-6-7-23(25-18-22)26-14-16-29(17-15-26)35(31,32)28-10-4-3-5-11-28/h6-7,18,20-21H,3-5,8-17,19H2,1-2H3
PubChem CID	46884936
ChEMBL	CHEMBL1090559
IUPHAR	N/A
BindingDB	50315152
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	118.0 %	PMID20227877	ChEMBL
EC50	1000.0 nM	PMID20227877	BindingDB,ChEMBL

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