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GPCR

NameAlpha-2B adrenergic receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneADRA2B
SynonymAlpha-2B adrenoceptor
Alpha-2B adrenoreceptor
Alpha-2BAR
DiseaseN/A for non-human GPCRs
Length394
Amino acid sequenceAIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNCKRTPRRIKCIILTVWLIAAAISLPPLIYKGDQGPQPHGAPQCKLNQEAWYILSSSLGSFFVPCLIMILVYLRIYLIAKRSHRRGPRAKGGPGEGESRQACPVPGGPSASAKLPTLATPVASASEANGPSKPAGEKEEGETPEDPGTQALPPGWATLPNSGQGQKEGVSGASLEEEAEEEEEEEEEEDEPQAVPVSPASVGSPPLQQPQGSRVLATLRGQVLVGRGVGAMSGQWWRRRAQLSREKRFTFVLAVVIGVFVLCWFPFFFSYSLSAICPQQCRVPHGLF
UniProtO77830
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

Name.delta.-Yohimbine
Molecular formulaC21H24N2O3
IUPAC namemethyl 16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate
Molecular weight352.434
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.7
SynonymsHydrosarpan
Lamuran
Ranitol
Raubaserp
Raubasil
[ Show all ]
Inchi KeyGRTOGORTSDXSFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3
PubChem CID251561
ChEMBLN/A
IUPHARN/A
BindingDB30993
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki376.0 nMPMID11408545BindingDB
Ki429.0 nMPMID11408545BindingDB

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