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GLASS

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GPCR

Name	Relaxin receptor 2
Species	Homo sapiens (Human)
Gene	RXFP2
Synonym	RXFPR2 RXFP2 relaxin/insulin like family peptide receptor 2 relaxin receptor 2 Relaxin family peptide receptor 2 LGR8 Leucine-rich repeat-containing G-protein coupled receptor 8 leucine-rich repeat-containing G protein-coupled receptor 8 INSL3 receptor GPR106 G-protein coupled receptor affecting testicular descent G-protein coupled receptor 106 [ Show all ]
Disease	N/A
Length	754
Amino acid sequence	MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProt	Q8WXD0
Protein Data Bank	2m96
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2m96.
BioLiP	BL0278456
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628482
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS000568644
Molecular formula	C20H12O5
IUPAC name	(6-oxobenzo[c]chromen-3-yl) phenyl carbonate
Molecular weight	332.311
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.8
Synonyms	AC1LETOM MolPort-001-938-800 ST50031517 BDBM95306 HMS1553L19 Oprea1_806402 (6-oxobenzo[c]chromen-3-yl) phenyl carbonate Carbonic acid 6-oxo-6H-benzo[c]chromen-3-yl ester phenyl ester SR-01000404646 AKOS000536691 CHEMBL1404472 Opera_ID_1268 TimTec1_006949 carbonic acid (6-ketobenzo[c]chromen-3-yl) phenyl ester HMS2326P10 REGID_for_CID_692203 6-oxobenzo[c]chromen-3-yl phenoxyformate CCG-104537 MLS002536805 SR-01000404646-1 BAS 00568057 cid_692203 Oprea1_756699 ZINC63677 (6-oxidanylidenebenzo[c]chromen-3-yl) phenyl carbonate carbonic acid (6-oxo-3-benzo[c][1]benzopyranyl) phenyl ester MCULE-2107436232 SMR000175478 [ Show all ]
Inchi Key	GRZFLTREEADAON-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H12O5/c21-19-17-9-5-4-8-15(17)16-11-10-14(12-18(16)25-19)24-20(22)23-13-6-2-1-3-7-13/h1-12H
PubChem CID	692203
ChEMBL	CHEMBL1404472
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	19438.4 nM	PubChem BioAssay data set	ChEMBL

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