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GPCR

NameProstaglandin F2-alpha receptor
SpeciesHomo sapiens (Human)
GenePTGFR
SynonymProstanoid FP receptor
prostaglandin F2-alpha receptor
prostaglandin F receptor (FP)
prostaglandin F receptor
PGF2-alpha receptor
[ Show all ]
DiseaseGlaucoma
Ocular disease
Renal cancer
Dysmenorrhea
Alzheimer disease
[ Show all ]
Length359
Amino acid sequenceMSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProtP43088
Protein Data BankN/A
GPCR-HGmod modelP43088
3D structure modelThis predicted structure model is from GPCR-EXP P43088.
BioLiPN/A
Therapeutic Target DatabaseT75797
ChEMBLCHEMBL1987
IUPHAR344
DrugBankBE0000610

Ligand

NameCHEMBL557109
Molecular formulaC16H19N3O3S
IUPAC nameN-(5-pentan-3-yl-1,3,4-thiadiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide
Molecular weight333.406
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.1
SynonymsMCULE-3926600831
AC1M2CFA
N-(5-pentan-3-yl-1,3,4-thiadiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide
ZINC2651404
MolPort-004-052-300
[ Show all ]
Inchi KeyGTHODMWAZRBYGQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H19N3O3S/c1-3-10(4-2)15-18-19-16(23-15)17-14(20)11-5-6-12-13(9-11)22-8-7-21-12/h5-6,9-10H,3-4,7-8H2,1-2H3,(H,17,19,20)
PubChem CID2114670
ChEMBLCHEMBL557109
IUPHARN/A
BindingDB50296437
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<25000.0 nMPMID19487124BindingDB,ChEMBL

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