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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1791200
Molecular formulaC147H249N45O41S
IUPAC name(3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2R,5S,8S,17R)-17-[[(2R)-2-[[(2R)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-[(2S)-butan-2-yl]-2-methyl-3,6,14,18-tetraoxo-1,4,7,13-tetrazacyclooctadecane-8-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3334.94
Hydrogen bond acceptor48
Hydrogen bond donor49
XlogP-12.0
SynonymsN/A
Inchi KeyGTLKAFGSLNIXOT-UNYURZGOSA-N
Inchi IDInChI=1S/C147H249N45O41S/c1-20-76(13)114-142(231)177-90(33-24-27-54-161-110(202)50-47-95(123(212)167-80(17)120(209)190-114)172-118(207)78(15)166-121(210)86(150)63-82-37-41-84(197)42-38-82)131(220)192-116(81(18)196)144(233)185-102(65-109(153)201)136(225)188-106(70-195)140(229)182-101(64-83-39-43-85(198)44-40-83)135(224)175-92(36-30-57-164-147(159)160)125(214)174-89(32-23-26-53-149)130(219)189-113(75(11)12)141(230)184-97(59-71(3)4)122(211)165-67-111(203)169-93(45-48-107(151)199)127(216)180-100(62-74(9)10)134(223)187-104(68-193)138(227)168-79(16)119(208)171-91(35-29-56-163-146(157)158)124(213)173-88(31-22-25-52-148)126(215)179-99(61-73(7)8)133(222)181-98(60-72(5)6)132(221)176-94(46-49-108(152)200)128(217)183-103(66-112(204)205)137(226)191-115(77(14)21-2)143(232)178-96(51-58-234-19)129(218)186-105(69-194)139(228)170-87(117(154)206)34-28-55-162-145(155)156/h37-44,71-81,86-106,113-116,193-198H,20-36,45-70,148-150H2,1-19H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,206)(H,161,202)(H,165,211)(H,166,210)(H,167,212)(H,168,227)(H,169,203)(H,170,228)(H,171,208)(H,172,207)(H,173,213)(H,174,214)(H,175,224)(H,176,221)(H,177,231)(H,178,232)(H,179,215)(H,180,216)(H,181,222)(H,182,229)(H,183,217)(H,184,230)(H,185,233)(H,186,218)(H,187,223)(H,188,225)(H,189,219)(H,190,209)(H,191,226)(H,192,220)(H,204,205)(H4,155,156,162)(H4,157,158,163)(H4,159,160,164)/t76-,77-,78+,79-,80+,81+,86+,87-,88-,89-,90-,91-,92-,93-,94-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-/m0/s1
PubChem CID56681688
ChEMBLCHEMBL1791200
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency0.002 -PMID9513600ChEMBL

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