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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL446896
Molecular formulaC10H17N5
IUPAC name5-methyl-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight207.281
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP0.5
SynonymsSCHEMBL2166254
AKOS019334843
Inchi KeyAOQGVDIPBIEREW-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H17N5/c1-8-7-12-10(11)13-9(8)15-5-3-14(2)4-6-15/h7H,3-6H2,1-2H3,(H2,11,12,13)
PubChem CID25130908
ChEMBLCHEMBL446896
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5066.07 nMPMID18811133ChEMBL
Efficacy81.0 %PMID18811133ChEMBL

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