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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameCHEMBL3104211
Molecular formulaC29H39FN4O2
IUPAC name2-[4-[4-[(2-cyclopentylacetyl)amino]-2-fluorophenyl]piperazin-1-yl]-N,N-diethyl-2-phenylacetamide
Molecular weight494.655
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.2
SynonymsBDBM50445670
SCHEMBL5081465
Inchi KeyAORILWRHGAKZKP-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H39FN4O2/c1-3-32(4-2)29(36)28(23-12-6-5-7-13-23)34-18-16-33(17-19-34)26-15-14-24(21-25(26)30)31-27(35)20-22-10-8-9-11-22/h5-7,12-15,21-22,28H,3-4,8-11,16-20H2,1-2H3,(H,31,35)
PubChem CID58870648
ChEMBLCHEMBL3104211
IUPHARN/A
BindingDB50445670
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC503000.0 nMPMID24365162BindingDB,ChEMBL

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