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GLASS

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GPCR

Name	Follicle-stimulating hormone receptor
Species	Homo sapiens (Human)
Gene	FSHR
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	Female infertility African trypanosomiasis Contraception Ovarian cancer
Length	695
Amino acid sequence	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProt	P23945
Protein Data Bank	4mqw
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqw.
BioLiP	BL0274372
Therapeutic Target Database	T68334
ChEMBL	CHEMBL2024
IUPHAR	N/A
DrugBank	BE0000387

Ligand

Name	CHEMBL360981
Molecular formula	C30H34N2O2
IUPAC name	N-(1-acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-4-propylbenzamide
Molecular weight	454.614
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.5
Synonyms	SCHEMBL1323445 BDBM50410307 GUHHQHLOTUGFKQ-UHFFFAOYSA-N 1-Acetyl-4-phenyl-6-(4-n-propylbenzoyl)amino-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
Inchi Key	GUHHQHLOTUGFKQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H34N2O2/c1-6-10-22-13-15-23(16-14-22)28(34)31-25-17-18-27-26(19-25)30(5,24-11-8-7-9-12-24)20-29(3,4)32(27)21(2)33/h7-9,11-19H,6,10,20H2,1-5H3,(H,31,34)
PubChem CID	11396885
ChEMBL	CHEMBL360981
IUPHAR	N/A
BindingDB	50410307
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5.0 nM	PMID15771412	BindingDB,ChEMBL

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