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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	BRN 4530212
Molecular formula	C19H23FN2O
IUPAC name	1-[3-(4-fluorophenoxy)propyl]-4-phenylpiperazine
Molecular weight	314.404
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.0
Synonyms	BDBM50362857 CHEMBL1940412 1-(3-(4-Fluorophenoxy)propyl)-4-phenylpiperazine 84344-34-3 Piperazine, 1-(3-(4-fluorophenoxy)propyl)-4-phenyl- DTXSID30233304 1-[3-(4-fluorophenoxy)propyl]-4-phenylpiperazine AC1MIH73 LS-112656 [ Show all ]
Inchi Key	GUOQPFNLBAXWIZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23FN2O/c20-17-7-9-19(10-8-17)23-16-4-11-21-12-14-22(15-13-21)18-5-2-1-3-6-18/h1-3,5-10H,4,11-16H2
PubChem CID	3069135
ChEMBL	CHEMBL1940412
IUPHAR	N/A
BindingDB	50362857
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	207.0 nM	PMID22245230	BindingDB,ChEMBL

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