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GPCR

NameLutropin-choriogonadotropic hormone receptor
SpeciesHomo sapiens (Human)
GeneLHCGR
Synonymlutropin-choriogonadotropic hormone receptor
Luteinizing hormone receptor
LSH-R
LHR
LH/CG-R
[ Show all ]
DiseaseHeart disease
Breast cancer
Cancer
Myelodysplastic syndrome
Female infertility
[ Show all ]
Length699
Amino acid sequenceMKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProtP22888
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT79473
ChEMBLCHEMBL1854
IUPHARN/A
DrugBankBE0000134

Ligand

NameMLS001116367
Molecular formulaC19H17ClN4O5S2
IUPAC name5-chloro-N-[4-[methyl(phenyl)sulfamoyl]phenyl]-2-methylsulfonylpyrimidine-4-carboxamide
Molecular weight480.938
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP2.3
SynonymsAKOS001873227
MCULE-9344992102
MolPort-000-399-296
5-chloro-N-(4-{[methyl(phenyl)amino]sulfonyl}phenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide
5-chloro-N-{4-[methyl(phenyl)sulfamoyl]phenyl}-2-(methylsulfonyl)pyrimidine-4-carboxamide
[ Show all ]
Inchi KeyGVDDPQRQWABRJN-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H17ClN4O5S2/c1-24(14-6-4-3-5-7-14)31(28,29)15-10-8-13(9-11-15)22-18(25)17-16(20)12-21-19(23-17)30(2,26)27/h3-12H,1-2H3,(H,22,25)
PubChem CID16012865
ChEMBLCHEMBL1332454
IUPHARN/A
BindingDB67354
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency30131.3 nMPubChem BioAssay data setChEMBL

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