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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameBDBM50104032
Molecular formulaC152H221N43O47S3
IUPAC name(3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(4R,7S,10S,16S,19R)-19-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-16-(3-amino-3-oxopropyl)-7-benzyl-10-[(1R)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3498.87
Hydrogen bond acceptor55
Hydrogen bond donor53
XlogP-15.0
SynonymsHis-Cys-Gln-Gly-Thr-Phe-Cys-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Inchi KeyGWOUGJDOIVXMGN-VJWIUXAKSA-N
Inchi IDInChI=1S/C152H221N43O47S3/c1-72(2)51-96(132(223)175-95(46-50-243-10)131(222)183-103(59-115(158)206)142(233)195-122(77(9)200)150(241)242)178-137(228)102(57-82-63-166-88-28-18-17-27-86(82)88)182-130(221)94(42-45-114(157)205)176-148(239)120(74(5)6)194-141(232)101(54-79-25-15-12-16-26-79)181-138(229)104(60-117(208)209)184-129(220)93(41-44-113(156)204)170-123(214)75(7)169-126(217)90(30-21-48-164-151(159)160)171-127(218)91(31-22-49-165-152(161)162)173-144(235)108(67-197)189-140(231)106(62-119(212)213)185-133(224)97(52-73(3)4)177-134(225)98(55-80-32-36-84(201)37-33-80)179-128(219)89(29-19-20-47-153)172-143(234)107(66-196)188-135(226)99(56-81-34-38-85(202)39-35-81)180-139(230)105(61-118(210)211)186-145(236)109(68-198)190-147(238)111-70-245-244-69-110(191-124(215)87(154)58-83-64-163-71-168-83)146(237)174-92(40-43-112(155)203)125(216)167-65-116(207)193-121(76(8)199)149(240)187-100(136(227)192-111)53-78-23-13-11-14-24-78/h11-18,23-28,32-39,63-64,71-77,87,89-111,120-122,166,196-202H,19-22,29-31,40-62,65-70,153-154H2,1-10H3,(H2,155,203)(H2,156,204)(H2,157,205)(H2,158,206)(H,163,168)(H,167,216)(H,169,217)(H,170,214)(H,171,218)(H,172,234)(H,173,235)(H,174,237)(H,175,223)(H,176,239)(H,177,225)(H,178,228)(H,179,219)(H,180,230)(H,181,229)(H,182,221)(H,183,222)(H,184,220)(H,185,224)(H,186,236)(H,187,240)(H,188,226)(H,189,231)(H,190,238)(H,191,215)(H,192,227)(H,193,207)(H,194,232)(H,195,233)(H,208,209)(H,210,211)(H,212,213)(H,241,242)(H4,159,160,164)(H4,161,162,165)/t75-,76+,77+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-/m0/s1
PubChem CID91931736
ChEMBLCHEMBL441011
IUPHARN/A
BindingDB50104032
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity1.5 %PMID11543679ChEMBL
IC50101.0 nMPMID11543679BindingDB,ChEMBL

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